Results 211 to 220 of about 42,427 (286)

Sphingosine‐1‐Phosphate Promotes FOS Activation in Osteosarcoma Under Tumor Acidosis

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim The tumor microenvironment in solid tumors is characterized by extracellular acidosis, which promotes cancer aggressiveness. In osteosarcoma, the most common primary bone cancer, a highly acidic tumor microenvironment is associated with metastasis and poor prognosis, partly due to metabolic rewiring, including changes in lipid pathways ...
Nicolò Bozzini, Margherita Cortini, Alberto Righi, Agamemnon E. Grigoriadis, Michael Dack, Elizabeta Ilieva, Federica Torricelli, Veronica Manicardi, Nicola Baldini, Sofia Avnet   +9 more
wiley   +1 more source

The n-3 PUFA content of the global lipidomes of NIST SRM 2378, SRM 1950, and intralaboratory quality control materials. [PDF]

J Lipid Res
Stark KD, Steckel KE, Kiebish M, Aristizabal-Henao JJ.   +3 more
europepmc   +1 more source

High cholesterol absorption efficiency enhances proatherogenic properties of low‐density lipoprotein particles

Journal of Internal Medicine, Volume 299, Issue 6, Page 711-725, June 2026.
Abstract Background and Aims High cholesterol absorption efficiency is determined by genetic variation in small intestinal sterol transporters and affects one‐third of individuals. Their risk for atherosclerotic cardiovascular disease (ASCVD) is increased compared with low cholesterol absorbers, despite similar serum lipid concentrations.
Katariina Öörni, Lauri Äikäs, Maija Ruuth, Feven Tigistu‐Sahle, Reijo Käkelä, Ingmar Wester, Helena Gylling, Piia Simonen   +7 more
wiley   +1 more source

Untargeted Metabolomic and Lipidomic Profiling Reveals Distinct Biochemical Patterns in Treated Biotinidase Deficiency. [PDF]

Int J Mol Sci
Ünlü Torlak E, Koç Yekedüz M, Bülbül YE, Kara İS, Erdoğan Kablan S, Eylem CC, Uçar B, Süslü İ, Baysal İ, Yabanoğlu Çiftçi S, Eminoğlu FT, Nemutlu E, Köse E.   +12 more
europepmc   +1 more source

Immune endotypes in tuberculosis: Keys to decoding disease complexity

Journal of Internal Medicine, Volume 299, Issue 6, Page 670-693, June 2026.
Abstract Tuberculosis (TB) remains a major global health challenge, with multi‐drug antibiotic regimens as the current standard of care. While effective at killing Mycobacterium tuberculosis, these treatments do not resolve persistent inflammation, prevent lung damage, or reverse immune dysregulation that contribute to poor outcomes and disease ...
Shamila D. Alipoor, Julia Guthrie, Lina Davies Forsman, Andrew R. Di Nardo, Susanna Brighenti   +4 more
wiley   +1 more source

Distinct Roles of Myeloid‐ and Hepatocyte‐PLA2G6 Deletion in Mice With Metabolic Dysfunction‐Associated Steatotic Liver Disease

Liver International, Volume 46, Issue 6, June 2026.
ABSTRACT Background and Aims Polymorphisms of group VIA calcium‐independent phospholipase A2 (iPLA2β or PLA2G6) are associated with Type‐2 diabetes, blood lipids and inflammation. Global deficiency in iPLA2β‐null mice elicited protection against hepatic steatosis but not hepatic inflammation after high‐fat diet (HFD) feeding.
Gang Li, Simone Staffer, Sabine Tuma‐Kellner, Uta Merle, Walee Chamulitrat   +4 more
wiley   +1 more source

<i>Toxoplasma gondii</i> assembles extracellular vesicles with conserved lipid profiles across host cell types. [PDF]

Front Cell Infect Microbiol
Cruz-Bustos T, Joachim A.
europepmc   +1 more source

Asymptomatic Versus Symptomatic Alzheimer's Disease Neuropathology: A Systematic Review of Differences Reported in Post‐Mortem Studies

Neuropathology and Applied Neurobiology, Volume 52, Issue 3, June 2026.
Graphical summary of post‐mortem brain tissue findings that differ between symptomatic and asymptomatic AD. Current evidence suggests reduced accumulation of Aβ and p‐tau oligomers, particularly at synapses, preserved neuronal and synaptic integrity and metabolic activity and a dynamic profile of glial and immune responses in ASYMAD.
Thiago Guilherme Rêgo Barros, Laura Barbosa Grossi, Maria Letícia da Silva Campos, Israel Bem‐Hur Netto Cardoso, Antônio Lúcio Teixeira, Aline Silva de Miranda, Eliana Cristina de Brito Toscano   +6 more
wiley   +1 more source

A bio-fortified whole tomato food supplement as potential dietary tool for the management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). [PDF]

J Transl Med
Natali PG, Imberti L, Piantelli M, Minacori M, Sottini A, Gianazza E, Banfi C.   +6 more
europepmc   +1 more source