Results 231 to 240 of about 42,427 (286)

Plant Protease Inhibitors Induced Oxidative and Nutritional Stress in <i>Helicoverpa armigera</i> Unveils Multifaceted Survival Strategies: A Lipidomic and Metabolomic View. [PDF]

ACS Omega
Dewangan V, Gupta SK, Deshpande N, Lomate PR, Kumar Y, Giri AP.   +5 more
europepmc   +1 more source

Rosa roxburghii‐Derived Exosome‐Like Nanovesicles Alleviate Ulcerative Colitis Based on Th17/Treg Immune Balance and Gut Microbiota Modulation

Food Frontiers, Volume 7, Issue 3, May 2026.
Rosa roxburghii‐derived exosome‐like nanovesicles target the intestine, repairing barriers, regulating gut microbiota, balancing Th17/Treg, and combating oxidative stress/inflammation to alleviate colitis, a promising UC therapy. ABSTRACT Plant‐derived nanovesicles (PDVs), an innovative and bioactive form of natural products, are key mediators of ...
Yuanyuan Wang, Yan Zeng, Guoying Liu, Hai Zou, Jie Wang, Jun Zhang, Ketao Jin, Zhangfeng Zhong, Xiaozhou Mou   +8 more
wiley   +1 more source

Brain lipidomics for region-specific biomarker discovery in neurodegenerative diseases. [PDF]

Front Aging Neurosci
Jayaprakash J, Gizaw ST, Gowda D, Hinou H, Nishimura SI, Hui SP, B Gowda SG.   +6 more
europepmc   +1 more source

Lipidome Analysis of Cancer Cells and Their Extracellular Vesicles Reveals Cancer‐Type‐Specific Lipid Signatures and Enables the Design of EV‐Mimetic Liposomes

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
ABSTRACT Lipid metabolism reprogramming is a hallmark of cancer, yet the global lipidome of cancer cells and their extracellular vesicles (EVs) remains poorly understood. Using mass spectrometry, we analyzed the lipid profiles of a panel of human cancer and non‐cancer cell lines along with their secreted EVs.
Noélie Douanne, Yousra Benslimane, Rubén R. López, Prisca Bustamante, Thupten Tsering, Yunxi Chen, Laura Kienzle, Masoud Ghasemi, Lorne Taylor, Yuning Chen, Anaïs Toreja Boutin, David Juncker, Catherine Mounier, Vahé Nerguizian, Julia V. Burnier   +14 more
wiley   +1 more source

Plasma lipid remodeling during the early recovery phase after myocardial infarction. [PDF]

Sci Rep
Myszko M, Bychowski J, Radziwon P, Skrzydlewska E, Łuczaj W.   +4 more
europepmc   +1 more source

Extracellular Vesicles in Osteoarthritis: From Pathogenic Mediators to Engineered Therapeutics in a Precision Medicine Roadmap

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
ABSTRACT Osteoarthritis (OA) remains without disease‐modifying sssstherapies, in part due to biological heterogeneity and a hostile joint microenvironment that undermines one‐size‐fits‐all interventions. Extracellular vesicles (EVs) play a dual role in OA pathophysiology: endogenous EVs disseminate pro‐inflammatory and catabolic signals that propagate ...
Duc‐Hiep Bach, Van Giang Bui, Thanh Liem Nguyen   +2 more
wiley   +1 more source

Multiplexed LC-MS analysis reveals novel insights into grapevine defense mechanisms by expanding metabolome coverage. [PDF]

Metabolomics
Vásquez-Ocmín PG, Pérez A, Romeo-Oliván A, Puech-Pages V, Fournier S, Dumas B, Jacques A, Marti G.   +7 more
europepmc   +1 more source

Metabolism Controls the Timing of Human Brain Development and Maturation

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT Among primates the human brain is the largest in size, exhibiting a higher neuronal density and connectivity. The prolonged expansion and subsequent connectome reorganization of the human brain have been suggested to promote higher cognitive and behavioral abilities.
Valentina Rava, Erica Cannone, Maura Francolini, Elena Taverna   +3 more
wiley   +1 more source

Empagliflozin-induced lipidome remodeling in type 2 diabetes: mechanistic insights and translational perspectives. [PDF]

Cardiovasc Diabetol
Izzo C, Carrizzo A.
europepmc   +1 more source

Aminoacyl‐tRNA Synthetases: Variant Classification, Functional Assays, and Emerging Therapeutic Strategies

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT Aminoacyl‐tRNA synthetases (aaRS) are essential enzymes that charge tRNAs with their corresponding amino acids, playing a critical role in protein synthesis. All 37 nuclear‐encoded ARS genes, comprising both cytosolic (ARS1) and mitochondrial (ARS2) isoforms, have now been linked to human disease.
M. I. Mendes, D. E. Smith, V. Spek, A. M. Bosch, W. E. Corpeleijn, M. Engelen, S. A. Fuchs, A. Hadchouel, I. U. Heinemann, R. H. Houtkooper, E. M. M. Hoytema van Konijnenburg, S. Kemp, M. Langeveld, C. D. M. Karnebeek, A. Pop, V. M. Siu, N. I. Wolf, G. S. Salomons   +17 more
wiley   +1 more source