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Shotgun lipidomics: multidimensional MS analysis of cellular lipidomes
Expert Review of Proteomics, 2005Shotgun lipidomics, comprised of intrasource separation, multidimensional mass spectrometry and computer-assisted array analysis, is an emerging powerful technique in lipidomics. Through effective intrasource separation of predetermined groups of lipid classes based on their intrinsic electrical propensities, analyses of lipids from crude extracts of ...
Xianlin, Han, Richard W, Gross
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Lipidomics of Alzheimer’s Disease
Bioanalysis, 2014Alzheimer's disease (AD) is a progressive brain disease that leads to an irreversible loss of neurons and cognition. It is the most common cause of dementia and can be considered as a major public health problem. At the histological level, AD is characterized by senile plaques and neurofibrillary tangles.
Touboul, David, Gaudin, Mathieu
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2007
Lipids are recognized as key participants in the regulation and control of cellular function, having important roles in signal transduction processes. The diversity in lipid chemical structure presents a challenge for establishing practical methods to generate and manage high volumes of complex data that translate into a snapshot of cellular lipid ...
Eoin, Fahy +8 more
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Lipids are recognized as key participants in the regulation and control of cellular function, having important roles in signal transduction processes. The diversity in lipid chemical structure presents a challenge for establishing practical methods to generate and manage high volumes of complex data that translate into a snapshot of cellular lipid ...
Eoin, Fahy +8 more
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Quantitative Profiling of Lysosomal Lipidome by Shotgun Lipidomics
2017Recent studies have illuminated novel roles of lysosomes that go far beyond simple catabolism and function in the coordination of cellular metabolism and signaling. Promising therapeutic strategies emerge from knowledge in the molecular mechanisms and physiological roles of lipid metabolism in lysosomes.
Mesut Bilgin +3 more
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Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2003
Michel, Lagarde +4 more
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Michel, Lagarde +4 more
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