Results 11 to 20 of about 3,138 (148)
Seeing Invisible Oligomers: Rethinking α‐Synuclein Pathology Through Proximity Ligation Assay [PDF]
Movement Disorders, Volume 41, Issue 7, Page 1680-1689, July 2026.Abstract Parkinson's disease (PD) and multiple system atrophy are defined by α‐synuclein (αSYN)‐positive inclusions – Lewy bodies (LBs) and glial cytoplasmic inclusions – yet mounting evidence indicates that these inclusions represent only a fraction of disease‐relevant pathology.
Hiroaki Sekiya +3 more
wiley +2 more sources
Juvenile Family Amaurotic Idiocy [PDF]
, 1960 This rare disease, considered on of the lipidoses in modern nosology, is presented as a case report of a family in which four siblings were afflicted with the disease. Included in this paper are the clinical and morbid histological findings of one of the
Elliff, John Edgar
core +8 more sources
Insect Molecular Biology, Volume 32, Issue 6, Page 658-675, December 2023., 2023 Nutritional starvation of honey bee colonies has long‐term negative consequences on honey production, even after the colonies were left to recover on good floral resources. Nutritional stress in honey bees leads to increased unsaturations of stored lipids.
Clara E. Castaños +6 more
wiley +1 more source
Advances in therapies for neurological lysosomal storage disorders
Journal of Inherited Metabolic Disease, Volume 46, Issue 5, Page 874-905, September 2023., 2023 Abstract Lysosomal Storage Disorders (LSDs) are a diverse group of inherited, monogenic diseases caused by functional defects in specific lysosomal proteins. The lysosome is a cellular organelle that plays a critical role in catabolism of waste products and recycling of macromolecules in the body.
S. Ellison, H. Parker, B. Bigger
wiley +1 more source
Equine Veterinary Education, Volume 35, Issue 6, Page 311-320, June 2023., 2023 Summary Background Hyperinsulinaemia‐associated laminitis (HAL) is encountered commonly in equine practice. There are currently no registered medications which specifically target hyperinsulinaemia in horses and ponies. Sodium–glucose cotransporter 2 inhibitors (SGLT2i) have been demonstrated to limit post‐prandial insulin responses and prevent the ...
Tania Sundra, Erin Kelty, David Rendle
wiley +1 more source
Veterinary Dermatology, Volume 33, Issue 5, Page 402-406, October 2022., 2022 Abstract Background In humans, the acidic pH of the ear canal plays a protective role against infection and a change towards alkalinity of the external auditory canal (EAC) is a local factor in the progression of acute to chronic otitis externa (OE).
Pauline Panzuti +5 more
wiley +1 more source
Food Science &Nutrition, Volume 10, Issue 1, Page 115-121, January 2022., 2022 In infancy, the diet requires both, an especially high nutritional quality and toxicological safety. In view of the recent TDI for erucic acid issued by EFSA, our scenarios show that the nutritionally safe food‐based dietary guidelines for infancy in Germany may no longer be safe with regard to potential exposure to erucic acid that originates mainly ...
Mathilde Kersting +4 more
wiley +1 more source
Clinical and genetic analysis of lipoprotein glomerulopathy patients caused by APOE mutations
Molecular Genetics &Genomic Medicine, Volume 8, Issue 8, August 2020., 2020 For the first time APOE‐Osaka/Kurashiki and APOE‐Chicago mutations reported in Chinese; Lipoprotein glomerulopathy (LPG) patients with urine protein remission had slower renal function decrease; LPG was associated with higher blood pressure; Serum apoE levels were higher in patients with low‐density lipoprotein receptor binding region mutations of APOE
Mingxin Yang +13 more
wiley +1 more source
Traffic, Volume 21, Issue 1, Page 60-75, January 2020., 2020 Over the last decade, we witnessed an unprecedented interest in lysosomes, most prominently as catabolic centers and as intracellular signaling platforms. Interestingly, lysosomal activity is strongly dependent on organelle numbers, size and position. The dynamic nature of lysosomes has been extensively documented but the importance of lysosomal size ...
Mariana E. G. de Araujo +3 more
wiley +1 more source
Orphanet Journal of Rare Diseases, 2010 Niemann-Pick C disease (NP-C) is a neurovisceral atypical lysosomal lipid storage disorder with an estimated minimal incidence of 1/120 000 live births.
Vanier Marie T
doaj +1 more source