Results 21 to 30 of about 2,942 (146)
Lipids in Health and Disease, 2022 Background Recent findings show that extracellular vesicle constituents can exert short- and long-range biological effects on neighboring cells in the brain, opening an exciting avenue for investigation in the field of neurodegenerative diseases ...
Melissa R. Pergande +6 more
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Deficiency of a Niemann-Pick, type C1-related protein in toxoplasma is associated with multiple lipidoses and increased pathogenicity. [PDF]
PLoS Pathogens, 2011 Several proteins that play key roles in cholesterol synthesis, regulation, trafficking and signaling are united by sharing the phylogenetically conserved 'sterol-sensing domain' (SSD).
Bao Lige +7 more
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Arquivos de Neuro-Psiquiatria, 1955 Les lipidoses constituent un groupe d'affections systématisées, caractérisées par une surcharge lipidique des tissus (en premier lieu du système réticulo-endothélial, accessoirement aussi de divers parenchymes).
D. Klein, A. Franceschetti, J. Babel
doaj +1 more source
Estudo da doença de Gaucher em Santa Catarina Study of Gaucher disease in Santa Catarina
Revista Brasileira de Hematologia e Hemoterapia, 2008 A doença de Gaucher (DG) foi a primeira doença de armazenamento lisossomal descrita e a mais encontrada. Caracteriza-se pela deficiência hereditária da atividade da enzima lisossomal glucocerebrosidase, que bloqueia o metabolismo do glicocerebrosídeo.
Jovino S. Ferreira +2 more
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Leucodistrofia metacromática: registro de um caso
Arquivos de Neuro-Psiquiatria, 1980 É relatado um caso de leucodistrofia metacromática em paciente com três anos de idade. O exame histopatológico revelou inclusões metacromáticas dentro do citoplasma dos neurônios, o que permite comentar sobre a fisiopatogenia desta doença, grupando-a ...
Osvaldo J. M. Nascimento +3 more
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Clinical and genetic analysis of lipoprotein glomerulopathy patients caused by APOE mutations
Molecular Genetics &Genomic Medicine, Volume 8, Issue 8, August 2020., 2020 For the first time APOE‐Osaka/Kurashiki and APOE‐Chicago mutations reported in Chinese; Lipoprotein glomerulopathy (LPG) patients with urine protein remission had slower renal function decrease; LPG was associated with higher blood pressure; Serum apoE levels were higher in patients with low‐density lipoprotein receptor binding region mutations of APOE
Mingxin Yang +13 more
wiley +1 more source
Traffic, Volume 21, Issue 1, Page 60-75, January 2020., 2020 Over the last decade, we witnessed an unprecedented interest in lysosomes, most prominently as catabolic centers and as intracellular signaling platforms. Interestingly, lysosomal activity is strongly dependent on organelle numbers, size and position. The dynamic nature of lysosomes has been extensively documented but the importance of lysosomal size ...
Mariana E. G. de Araujo +3 more
wiley +1 more source
Orphanet Journal of Rare Diseases, 2010 Niemann-Pick C disease (NP-C) is a neurovisceral atypical lysosomal lipid storage disorder with an estimated minimal incidence of 1/120 000 live births.
Vanier Marie T
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Cherry Anthocyanins Regulate NAFLD by Promoting Autophagy Pathway
Oxidative Medicine and Cellular Longevity, Volume 2019, Issue 1, 2019., 2019 Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease that threatens human health, and present therapies remain limited due to the lack of effective drugs. Lipid metabolic disturbance and oxidative stress have strong links to the development of NAFLD, while autophagy was generally accepted as a key regulatory mechanism on these steps ...
Qiang Chu +7 more
wiley +1 more source
Lipid Storage Myopathy in Behçet′s Disease: A Rare Cause of Elevated Serum Creatine Kinases Levels
Case Reports in Rheumatology, Volume 2012, Issue 1, 2012., 2012 Muscular involvement in Behçet’s disease is rare and there are only a few case reports in the literature. The causes of elevated muscle enzymes in a patient with Behcet’s disease are many, including myositis, drug‐induced myopathy, metabolic myopathy, and the disease itself.
Sedat Yilmaz +9 more
wiley +1 more source