Results 101 to 110 of about 1,588,563 (356)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
First-order phase transition of triangulated surfaces on a spherical core
, 2011 We study an intrinsic curvature model defined on fixed-connectivity triangulated lattices enclosing a spherical core by using the canonical Monte Carlo simulation technique.
Ambjorn +36 more
core +1 more source
Sedimentary membrane lipids recycled by deep-sea benthic archaea [PDF]
, 2010 http://www.godac.jamstec.go.jp/darwin/cruise/natsushima/nt06-04/ehttp://www.godac.jamstec.go.jp/darwin/cruise/natsushima/nt06-05/ehttp://www.godac.jamstec.go.jp/darwin/cruise/natsushima/nt06-22/ehttp://www.godac.jamstec.go.jp/darwin/cruise/natsushima ...
CHIKARAISHI, Yoshito +17 more
core +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla +5 more
wiley +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova +26 more
wiley +1 more source
Manual pressing of nannochloropsis oculata dried biomass for enhanced lipid extraction [PDF]
, 2017 Microalgae offer significant potential to produce high value products and biofuels, whilst simultaneously being used to bio-remediate water or capture carbon dioxide (CO2).
Ali, Mehmood, Watson, Ian
core
Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs
Molecular Oncology, EarlyView.In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza +3 more
wiley +1 more source
THE FATTY ACID PATTERNS OF PLASMA LIPIDS DURING ALIMENTARY LIPEMIA* [PDF]
, 1959 Vincent P. Dole +4 more
openalex +1 more source