Results 141 to 150 of about 2,038,756 (358)
Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue
Advanced Functional Materials, EarlyView.Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas +12 morewiley +1 more sourceA microbiota‐based predictive model for type 2 diabetes remission induced by dietary intervention: From the CORDIOPREV study
Clinical and Translational Medicine, 2021 Cristina Vals‐Delgado, Juan F. Alcala‐Diaz, Irene Roncero‐Ramos, Ana Leon‐Acuña, Helena Molina‐Abril, Francisco M. Gutierrez‐Mariscal, Juan L. Romero‐Cabrera, Silvia de laCruz‐Ares, Ben vanOmmen, Justo P. Castaño, Jose M. Ordovas, Pablo Perez‐Martinez, Javier Delgado‐Lista, Antonio Camargo, Jose Lopez‐Miranda +14 moredoaj +1 more sourceLaser‐Induced Graphene from Waste Almond Shells
Advanced Functional Materials, EarlyView.Almond shells, an abundant agricultural by‐product, are repurposed to create a fully bioderived almond shell/chitosan composite (ASC) degradable in soil. ASC is converted into laser‐induced graphene (LIG) by laser scribing and proposed as a substrate for transient electronics.Yulia Steksova, Anna Chiara Bressi, Marina Galliani, Attilio Marino, Gianni Ciofani, Eduardo Machado‐Charry, Hilda Gomez Bernal, Alessandra Francini, Luca Sebastiani, Francesco Greco +9 morewiley +1 more sourceA cross-sectional study on the associations of insulin resistance with sex hormone, abnormal lipid metabolism in T2DM and IGT patients
, 2017 Xiaoxia Wang, Tongzhang Xian, Xiaofan Jia, Lina Zhang, Li Liu, Fuli Man, Xianbo Zhang, Jie Zhang, Qi Pan, Lixin Guo +9 moreopenalex +1 more sourceEffects of magnesium picolinate, zinc picolinate, and selenomethionine co-supplementation on reproductive hormones, and glucose and lipid metabolism-related protein expressions in male rats fed a high-fat diet
, 2022 Kazım Şahin, Cemal Orhan, O. Küçük, Mehmet Tuzcu, Nurhan Şahin, İbrahim H. Özercan, Sarah Sylla, Sara Perez Ojalvo, James Komorowski +8 moreopenalex +1 more sourceFeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma
Advanced Functional Materials, EarlyView.FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...Yukun Wu, Xue Li, Tong Wu, Dan Ji, Yugang Bai, Xuezhi Zhou +5 morewiley +1 more sourceSynergistic Osteogenesis After Co‐Administration of cmRNAs Encoding BMP‐2 and BMP‐7 Utilizing a Transcript‐Activated Matrix
Advanced Functional Materials, EarlyView.This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...Claudia Del Toro Runzer, Joanna M. Sadowska, Nadia Roumans, Christian Plank, Christopher H. Evans, Fergal J. O'Brien, Martijn van Griensven, Elizabeth R. Balmayor +7 morewiley +1 more source