Results 191 to 200 of about 28,509 (234)
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Quantification of age pigments (lipofuscin)
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 19881. Three methods have hitherto been applied for age pigment quantification: (a) numerically from micrographs; (b) fluorimetrically from histological sections; (c) spectrofluorimetrically from dissolved age pigments. 2. The spectrofluorimetric method is at present the most commonly used technique for quantification of age pigments. 3.
C, Hammer, E, Braum
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Proteasome Inhibition Enhances Lipofuscin Formation
Annals of the New York Academy of Sciences, 2002Abstract: Lipofuscin, a hallmark of aged nondividing cells, is an undegradable autofluorescent intralysosomal substance composed essentially of oxidized, cross‐linked proteins. To test whether impaired activity of proteasomes—which, along with lysosomes, belong to major cellular proteolytic systems—may contribute to lipofuscinogenesis, we exposed ...
Alexei, Terman, Sara, Sandberg
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Mitochondrial Lipofuscin and Thermomitochondrial Lipofuscin in Homogenates of Rat Organs
Biophysics, 2019Abstract—The amounts of lipofuscin (age pigment) were compared in four organs of rats: the liver, the kidney, the heart muscle, and the brain, as well as in a suspension of ghosts of hepatic mitochondria. It was shown that liver lipofuscin, which absorbs UV light at 360 nm and fluoresces at 460 nm, is predominantly formed due to mitochondrial processes.
A. V. Chaplygina, N. L. Vekshin
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Lipofuscin in Amyotrophic Lateral Sclerosis
Archives of Neurology, 1984Lipofuscin has been reported to accumulate in abnormal amounts in motor neurons of patients with amyotrophic lateral sclerosis (ALS). Microdensitometry was used to quantitate such lipid masses in spinal motor neurons in normal subjects compared with spinal motor neurons in ALS cases.
G B, McHolm, M J, Aguilar, F H, Norris
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Nutrition Reviews, 2009
Lipofuscin is the fluorescent mixture of compounds that accumulates increasingly with age in human tissues, including the pigment epithelium of the retina. A substantial component of lipofuscin has been identified in the retina as N-retinylidene-N-retinylethanolamine.
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Lipofuscin is the fluorescent mixture of compounds that accumulates increasingly with age in human tissues, including the pigment epithelium of the retina. A substantial component of lipofuscin has been identified in the retina as N-retinylidene-N-retinylethanolamine.
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The photoreactivity of ocular lipofuscin
Photochemical & Photobiological Sciences, 2004Lipofuscin or "age pigment" is a lipid-protein complex which accumulates in a variety of postmitotic, metabolically active cells throughout the body. These complexes, which are thought to result from the incomplete degradation of oxidised substrate, have the potential for photoreactivity.
Boulton, M +3 more
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Hepatocellular Lipofuscin in Pre‐Eclampsia
Asia-Oceania Journal of Obstetrics and Gynaecology, 1989AbstractThirty liver specimens from 30 pre‐eclamptic women with and without liver dysfunction were examined for the amount of lipofuscin pigment deposited. The amount of hepatic lipofuscin correlated positively with plasma urate concentrations. This finding may indicate an involvement of oxygen‐free radicals and xanthine oxidase in the pathophysiology ...
H, Minakami +4 more
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Potential reversibility of lipofuscin accumulation
Archives of Gerontology and Geriatrics, 2002It is well established that the lipofuscin content of many post-mitotic cell types increases progressively during normal senescence. This age-related accumulation of lipofuscin may occur either: (1) because lipofuscin, once formed, is never degraded or eliminated from cells; or (2) because, despite turnover of this pigment, the rate of lipofuscin ...
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Compositional studies of human RPE lipofuscin
Journal of Mass Spectrometry, 2010AbstractAge‐related macular degeneration (AMD) is an ocular disease that causes visual loss and legal blindness in the elderly population. The etiology of AMD is complex and may include genetic predispositions, accumulation of lipofuscin and drusen, local inflammation and neovascularization.
L S, Murdaugh +6 more
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LIPOFUSCIN ACCUMULATION AND AGEING OF FIBROBLASTS
Gerontology, 1995Lipofuscin accumulates in postmitotic cells. In human fibroblasts, accumulation of lipofuscin as measured by cellular autofluorescence is exponential at first, but stops at a certain level. At the same time, cell death starts to decrease cell numbers significantly.
T, von Zglinicki +3 more
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