Results 71 to 80 of about 1,553 (193)

Macrophages: Subtypes, Distribution, Polarization, Immunomodulatory Functions, and Therapeutics

MedComm, Volume 6, Issue 8, August 2025.
Macrophages originate from the yolk sac, fetal liver, and bone marrow, differentiating into two main subtypes: M1‐like (proinflammatory) and M2‐like (anti‐inflammatory). These subtypes exhibit high plasticity, allowing them to transform in response to environmental cues or therapeutic interventions.
Mengyuan Peng, Niannian Li, Hongbo Wang, Yaxu Li, Hui Liu, Yanhua Luo, Bao Lang, Weihang Zhang, Shilong Li, Liujun Tian, Bin Liu   +10 more
wiley   +1 more source

Clinicopathological Challenge: Five Males Presenting With Progressive Skin Thickening and Hoarse Voices

International Journal of Dermatology, Volume 64, Issue 7, Page 1161-1163, July 2025.
ABSTRACT Five male patients, including four siblings and one unrelated child, presented with progressive hoarseness, waxy eyelid papules, mucosal thickening, and skin plaques. Histopathologic analysis revealed PAS‐positive perivascular hyaline deposition, and genetic testing confirmed a homozygous ECM1 mutation in all patients, consistent with lipoid ...
R. Maxwell Regester, Molly Antonson, Nicole N. Harter   +2 more
wiley   +1 more source

Lipoid proteinosis: A case report

Journal of Dr. NTR University of Health Sciences, 2017
Lipoid proteinosis is a rare disorder, with only 300 cases reported in the medical literature. It is inherited as an autosomal recessive trait, characterized by the deposition of a hyaline material in the dermis and submucosal connective tissues ...
Ramakrishnan Bharathi, Santiago Gnanadeepam, Nallaiyan Parthiban, Arunkumar Kamalakaran   +3 more
doaj   +1 more source

The Novel Use of Daratumumab in the Treatment of Refractory Autoimmune Pulmonary Alveolar Proteinosis

Respirology Case Reports, Volume 13, Issue 6, June 2025.
We present a case of refractory autoimmune pulmonary alveolar proteinosis (aPAP) successfully treated with Daratumumab, a novel CD‐38 monoclonal antibody (mAb). ABSTRACT Autoimmune pulmonary alveolar proteinosis (aPAP) is caused by circulating anti‐granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) auto‐antibodies that impair alveolar macrophage
April Strong, Ying Sun, David Pilcher, Zane Kaplan, Rob G. Stirling   +4 more
wiley   +1 more source

Evaluating the Use of iPSC‐Derived Models in Understanding the Pathogenesis of Childhood Interstitial Lung Disease

Pediatric Pulmonology, Volume 60, Issue 5, May 2025.
ABSTRACT Rationale Genetic testing has significantly improved the diagnosis of childhood interstitial lung diseases (chILD), which have long challenged clinicians due to their heterogeneity and poor characterization. It is now imperative to study variants of unknown significance (VUS) to identify pathogenic mutations to optimize diagnosis and screening
Swetha Jinson, Shivanthan Shanthikumar, Rhiannon B. Werder   +2 more
wiley   +1 more source

Pediatric interstitial lung disease [PDF]

, 2022
Interstitial lung disease in children (chILD) is rare and encompasses more than 200 entities, with new especially genetic causes being discovered. Several classifications have been proposed, and there is considerable overlap with entities which present ...
Bush, Andrew, Gilbert, Carlee, Gregory, Jo, Nicholson, Andrew Gordon, Pabary, Rishi, Semple, Thomas, Zampoli, Marco   +6 more
core   +1 more source

Periodic Table of Immunomodulatory Elements and Derived Two‐Dimensional Biomaterials

Advanced Science, Volume 12, Issue 6, February 10, 2025.
Two‐dimensional (2D) nanomaterials, possessing unique physiochemical properties, revolutionize the field of biomedical engineering to address critical diagnostic and therapeutic challenges. This review unveils the periodic table of 2D immunomodulatory elements, assessing synthesis, properties, immunomodulatory mechanisms and biocompatibility.
Alireza Rafieerad, Leena Regi Saleth, Soofia Khanahmadi, Ahmad Amiri, Keshav Narayan Alagarsamy, Sanjiv Dhingra   +5 more
wiley   +1 more source

Lipoid proteinosis in two siblings

Indian Journal of Dermatology, 2006
Lipoid proteinosis denotes a rare autosomal recessive disorder. We report here lipoid proteinosis in a 31-year-old unmarried female along with her sibling.
Behera Samira Kumar, Nayak Surajit, Debi Basanti, Sahu Antaryami, Mishra Debiprasad   +4 more
doaj  

A rare genetic disorder encountered in dentistry: a case of lipoid proteinosis [PDF]

Lipoid proteinosis disease is a rare autosomal recessive genodermatosis first described by Urbach and Wiethe in 1929. This disease occurs as a result of homozygous or compound heterozygous mutations in the ECM1 gene located in the 1q21 chromosome region.
Dogan, Mehmet Sinan, Yavuz, Izzet, Yazmaci, Betul   +2 more
core   +2 more sources

SCARF2 is a target for chronic obstructive pulmonary disease: Evidence from multi‐omics research and cohort validation

Aging Cell, Volume 23, Issue 10, October 2024.
This study integrated genome, transcriptome, and proteome data to explore the potential target for chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), and found the robust associations of SCARF2with them. Furthermore, single cell transcriptome analysis implicated that SCARF2was lowly expressed in epithelial cells for ...
Sai Wang, Yuanyi Yue, Xueqing Wang, Yue Tan, Qiang Zhang   +4 more
wiley   +1 more source