This study establishes pharmacological microglial inhibition as a therapeutic strategy, demonstrating its capacity to remodel the lesion microenvironment through significant reduction of extracellular matrix deposition. This permissive environmental transformation facilitates robust regeneration of the reticulospinal tract, and reconstructs functional ...
Run Li +11 more
wiley +1 more source
Mass spectrometric profiling of microbial polysaccharides using laser desorption/ionization - time-of-flight (LDI-TOF) and liquid chromatography-mass spectrometry (LC-MS): a novel method for structural fingerprinting and derivatization. [PDF]
Dadovska L +3 more
europepmc +1 more source
Regulation of Neuroinflammation by Microglial DUBA‐IRAK1‐IKKβ Signaling Loop
The protein levels of deubiquitinating enzyme A (DUBA) are rapidly upregulated in microglia after activation of Toll‐like receptor 4 (TLR4). In turn, DUBA potentiates TLR4‐induced proinflammatory signal transduction in microglia by stabilizing interleukin‐1 receptor activated kinase 1 (IRAK1) through K48 deubiquitination.
Zhenhu Zhu +22 more
wiley +1 more source
Structural Studies on the O-Specific Side Chains of the Cell Wall Lipopolysaccharide from Salmonella bredeney. [PDF]
Carl Gustaf Hellerqvist +5 more
openalex +1 more source
Nanographene oxide (NGO) attenuates graft‐versus‐host disease (GVHD) severity by inhibiting STAT1‐mediated M1 macrophage polarization and suppressing T‐cell activation. NGO‐primed macrophages (NGO‐Mac) further enhance regulatory T‐cell induction via IL‐10. Both NGO and NGO‐Mac therapies mitigate inflammation and immune pathology, offering cell‐free and
Aaron Yu +18 more
wiley +1 more source
Single-cell analysis of lipopolysaccharide-mediated heterogeneity in Escherichia coli adhesion and mechanics. [PDF]
Laskowski D, Strzelecki J.
europepmc +1 more source
The 6-O-Methylglucose-containing Lipopolysaccharide of Mycobacterium phlei
Milton H. Saier, Clinton E. Ballou
openalex +1 more source
A modular antimicrobial‐peptide‐based therapeutic system integrating membrane‐targeted selectivity, a conformation‐driven polyethylene glycolylated blocker, and serum‐stabilizing N‐cap is developed. The optimized conjugate 270 shows potent, rapid killing of the desired tumor cells, high serum stability, low off‐target toxicity, and broad applicability,
Tianxing Liu +12 more
wiley +1 more source
Wumei Pills enhance intestinal stem cell - mediated repair in chemotherapy-induced mucositis <i>via Lactobacillus reuteri</i> - dependent modulation of the gut microbiota. [PDF]
Lu DX +5 more
europepmc +1 more source

