Results 231 to 240 of about 304,856 (335)

Acute inflammation induced by the Escherichia coli lipopolysaccharide considerably increases the systemic and brain exposure of olanzapine after oral administration in mice

Jan Hubeňák, Martin Mžik, Hana Laštůvková, David Bayer, Lenka Jandova, Jolana Schreiberová, Ctirad Andrys, Stanislav Mičuda, Jiri Masopust, Jaroslav Chládek   +9 more
openalex   +1 more source

Iron Oxide Nanozyme as Reactive Oxygen and Nitrogen Species Scavenger to Regulate Microglial Homeostasis in Stroke

Advanced Science, EarlyView.
6 nm iron oxide nanoparticles (IONP6) exhibit enzyme‐like activities that scavenge reactive oxygen and nitrogen species (RONS), including nitric oxide (NO). In stroke models, IONP6 promotes microglial polarization toward the M2 phenotype, reduces neuroinflammation, and improves neurological outcomes, offering a promising drug‐free approach to mitigate ...
Yilin Qi, Chunxiao Wang, Yuqing Miao, Jiamin Li, Zengyu Xun, Di Sun, Fei Xu, Minrui Liu, Heping Wang, Galong Li, Xuyi Chen, Haiming Fan, Xue Xue   +12 more
wiley   +1 more source

Polymyxins slow down lateral diffusion of proteins and lipopolysaccharide in the E. coli outer membrane. [PDF]

Commun Biol
Prakaash D, Khalid S.
europepmc   +1 more source

MicroRNA‐223/NE Signaling Pathway Inhibits Lipopolysaccharide‐Induced Acute Lung Injury by Regulating Neutrophil Extracellular Traps [PDF]

Zhaohui Zeng, Yuexiang Qin, Xue Y. He, Zhaoxia Tan   +3 more
openalex   +1 more source

Single‐Cell Profiling: Any Scale, Any Size, All at Once

Advanced Science, EarlyView.
Traditional single‐cell technologies are constrained by cellular dimension and throughput scale, in addition to its inability preserve spatial information. With recent innovations, these technologies now allow high throughput, large‐sized cell, and multi‐modal profiling of patient samples, overcoming these limitations.
Denise Goh, Felicia Wee, Rachel Elizabeth Ann Fincham, Ruisi Li, Joe Yeong   +4 more
wiley   +1 more source

AI‐Based D‐Amino Acid Substitution for Optimizing Antimicrobial Peptides to Treat Multidrug‐Resistant Bacterial Infection

Advanced Science, EarlyView.
This study constructed the first D‐amino acid antimicrobial peptide dataset and developed an AI model for efficient screening of substitution sites, with 80% of candidate peptides showing enhanced activity. The lead peptide dR2‐1 demonstrated potent antimicrobial activity in vitro and in vivo, high stability, and low toxicity.
Yinuo Zhao, Qingzhou Kong, Haifan Gong, Lixiang Li, Jialu Fu, Boyao Wan, Peizhu Wang, Xiaojuan Li, Yue Wang, Jinghui Zhang, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +14 more
wiley   +1 more source

Linking gut permeability to liver steatosis: Noninvasive biomarker evaluation in MASLD patients - a prospective cross-sectional study. [PDF]

Medicine (Baltimore)
Dumitru A, Tocia C, Bădescu AC, Trandafir A, Alexandrescu L, Popescu R, Dumitru E, Chisoi A, Manea M, Matei E, Cozaru GC, Rugină S.   +11 more
europepmc   +1 more source

Substituent‐Based Modulation of Self‐Assembly and Immunogenicity of Amphipathic Peptides

Advanced Science, EarlyView.
This study systematically investigates how positional and subtle changes, such as substituents on the phenyl ring attached to short amphipathic peptides, influence their self‐assembly, fibril morphology, and immunogenic responses. ABSTRACT Self‐assembled peptide‐based biomaterials provide versatile platforms for biomedical uses, featuring customizable ...
Anirban Das, Ushasi Pramanik, Elise M. Brown, Chih‐Yun Liu, Huan Gong, Jonathan Fascetti, Mark Gibson, Samuel Stealey, Silviya P. Zustiak, Cory Berkland, Piyoosh Sharma, Meredith E. Jackrel, Mark A. White, Jai S. Rudra   +13 more
wiley   +1 more source

Cost-Effective and High-Throughput LPS Detection via Microdroplet Technology in Biopharmaceuticals. [PDF]

Biosensors (Basel)
Colombelli A, Lospinoso D, Arima V, Guarino V, Zizzari A, Bianco M, Perrone E, Carbone L, Rella R, Manera MG.   +9 more
europepmc   +1 more source

Lipopolysaccharide-Activated Dendritic Cells: “Exhausted” or Alert and Waiting?

, 2012
Kaveh Abdi, Nevil J. Singh, Polly Matzinger   +2 more
openalex   +2 more sources