Causal Effect of Low-Density Lipoprotein Cholesterol on Chronic Kidney Disease: A Mendelian Randomization Study. [PDF]
Biochem Res IntZhou D, Zheng K, Zhang S, Zheng B.
europepmc +1 more source
Multimorbidity and Associations with Cognition and Alzheimer's Disease Biomarkers
Annals of Neurology, EarlyView.Objective Multimorbidity, the coexistence of 2 or more chronic conditions, has been linked to cognitive aging and Alzheimer's disease (AD) and AD‐related dementias, yet the mechanisms remain unclear. We aimed to examine the associations of multimorbidity with cognition and biomarkers across multiple mechanistic pathways.
Xiaqing Jiang +45 more
wiley +1 more source
Leveraging the lipoprotein trafficking pathway for the development of novel antimicrobials. [PDF]
RSC Chem BiolGartrell HB +3 more
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Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles
Advanced NanoBiomed Research, EarlyView.This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
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Triglyceride-driven pathogenesis in thyroid-associated ophthalmopathy: a dual approach of clinical correlation and genetic causality. [PDF]
Int J OphthalmolCao JM, Chen HY, Zhang F, Xiong W.
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Advanced NanoBiomed Research, EarlyView.Lysyl oxidase crosslinking of type I collagen decreases neutrophil extravasation through an endothelium during the initial response to P. aeruginosa. This decrease in extravasation is likely due to the increase in VE‐cadherin expression between endothelial cells seeded on LOX‐crosslinked collagen hydrogels.
Christopher J. Calo +7 more
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Longitudinal Study of Frailty Phenotype in Relation to Chronic Kidney Disease Incidence. [PDF]
J Cachexia Sarcopenia MuscleRuan YX +13 more
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Beyond PEGylation: Archaeal Lipids for Long‐Circulating Liposomes
Advanced NanoBiomed Research, EarlyView.Archaeal lipid‐based liposomes, particularly those containing caldarchaeol (GDGT), were found to significantly prolong the circulation time of vancomycin in rats, matching the pharmacokinetic properties of PEGylated systems. These findings suggest archaeal lipids as promising non‐PEG excipients for parenteral applications to minimize drug clearance ...
Viktor Sedlmayr +9 more
wiley +1 more source
A nonlinear curve relating non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) to anxiety in American adults: A cross-sectional study. [PDF]
Medicine (Baltimore)Song L, Xu Y, Zhang Y.
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Advanced NanoBiomed Research, EarlyView.We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer +5 more
wiley +1 more source