Results 201 to 210 of about 864,255 (364)

FABP4 as a Mediator of Lipid Metabolism and Pregnant Uterine Dysfunction in Obesity

open access: yesAdvanced Science, EarlyView.
Obesity during late pregnancy contributes to uterine smooth muscle dysfunction, but the underlying mechanisms are unclear. This study identifies fatty acid binding protein 4 (FABP4) as a key player in the process, mediating excessive fatty acid uptake, lipid accumulation, and mitochondrial dysfunction in myometrial cells. FABP4 could be a novel uterine
Xuan Li   +11 more
wiley   +1 more source

Retardation of atherosclerosis in immunocompetent apolipoprotein (apo) E-deficient mice followingliver-directed administration of a [E1-, E3-,polymerase-] adenovirus vector containing the elongation factor-1a promoter driving expression of human apoE cDNA [PDF]

open access: yes, 2005
Although gene transfer of human apolipoprotein E (apoE), a 34-kDa circulating glycoprotein, to the liver of apoEdeficient(apoE-/-) mice using recombinant adenoviral vectors (rAd) is antiatherogenic, its full therapeutic potentialhas yet to be realized ...
Amalfitano, A   +6 more
core  

Methionine Metabolism Dictates PCSK9 Expression and Antitumor Potency of PD‐1 Blockade in MSS Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
xxxx. Abstract Nutrient metabolisms are vitally interrelated to cancer progression and immunotherapy. However, the mechanisms by which nutrient metabolisms interact to remodel immune surveillance within the tumor microenvironment remain largely unexplored.
Qi‐Long Wang   +16 more
wiley   +1 more source

Analysis of α-lipoprotein cholesterol in 50 μl of plasma

open access: yesJournal of Lipid Research, 1974
A micromethod for quantitation of α-lipoprotein cholesterol was devised for gas–liquid chromatography to minimize plasma sample size and facilitate lipid studies using capillary blood from children or small animals. α-Lipoprotein cholesterol was measured
R.F. Lutmer   +7 more
doaj  

Macrophage WEE1 Directly Binds to and Phosphorylates NF‐κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis

open access: yesAdvanced Science, EarlyView.
The present study shows that macrophage WEE1 drives NF‐κB activation and inflammatory atherosclerosis by directly phosphorylating p65 at S536. This finding illustrates a macrophage‐specific WEE1‐p65 axis in regulating inflammatory atherosclerosis and points out new directions to broaden the clinical applications for WEE1 inhibitors in atherosclerosis ...
Zhuqi Huang   +13 more
wiley   +1 more source

High-throughput isolation and characterization of untagged membrane protein complexes: outer membrane complexes of Desulfovibrio vulgaris. [PDF]

open access: yes, 2012
Cell membranes represent the "front line" of cellular defense and the interface between a cell and its environment. To determine the range of proteins and protein complexes that are present in the cell membranes of a target organism, we have utilized a ...
Allen, Simon   +16 more
core  

Electrochemical Determination of Gallic Acid in Tea Samples Using Pyramidal Pt Nanoparticles

open access: yesAdvanced Electronic Materials, EarlyView.
A novel electrochemical sensor based on pyramidal Pt nanoparticles for gallic acid detection in black and green tea samples is developed. The sensor is prepared by a simple drop casting of nanoparticles on the electrode surface, without any supporting materials, such as polymer matrices and surfactants.
Tiziano Di Giulio   +10 more
wiley   +1 more source

Human plasma CETP deficiency: identification of a novel mutation in exon 9 of the CETP gene in a Caucasian subject from North America

open access: yesJournal of Lipid Research, 1998
Human plasma cholesteryl ester transfer protein (CETP) is a 476-residue hydrophobic glycoprotein that catalyzes the heterotransfer of cholesteryl esters and triacylglycerols among lipoproteins: Mutations in the CETP gene have been identified, mostly in ...
Evelyn M. Teh   +3 more
doaj  

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