Artificial Internalizing Receptors for Targeted Degradation of Extracellular Proteins
Small organic molecules that are anchored into the lipid bilayer of a mammalian cell and have an exofacial recognition ligand can act as artificial internalizing receptors. These receptors are an efficacious tool to selectively capture and internalize cognate antibodies from the extracellular environment in a protein‐specific manner.
Ane B. Søgaard+3 more
wiley +1 more source
Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and gout in US adults: a cross-sectional study of the mediating role of BMI. [PDF]
Li H, Li X, Zhong W, Liu F.
europepmc +1 more source
Hologenomics Reveals Specialized Dietary Adaptations in the Mengla Snail‐Eating Snake
Dietary adaptation studies from a holobiome perspective are scarce beyond mammals. This research reveals how genomic and microbial interactions drive dietary specialization in the Mengla snail‐eating snake, with evidence of gut symbiont convergence between reptiles and mammals.
Chaochao Yan+10 more
wiley +1 more source
Associations of nontraditional lipoprotein ratios with future cardiovascular events in patients with type 2 diabetes mellitus. [PDF]
Deng SM, Hu XQ, Zhang XY.
europepmc +1 more source
Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy
Nanomaterial (NM)‐induced toxicity can be strategically repurposed for cancer therapy. This review summarizes the mechanism by which NMs selectively activate specific cellular processes to regulate cell fate independently. We also discussed how NMs‐induced biological responses can be leveraged as therapeutic strategies for cancer treatment.
Liting Wang+6 more
wiley +1 more source
Heart rate turbulence in type 2 diabetes mellitus with chronic kidney disease. [PDF]
Zhu H, Peng YF, Gu H, Liu X.
europepmc +1 more source
We develop an azido‐ and amino‐functionalized cholesterol probe that can be efficiently fixed and used for expansion microscopy (ExM). This cholesterol probe enables nanoscale tracking of cholesterol distribution dynamics in the endocytic pathway. Combining 10‐fold robust ExM and structured illumination microscopy allows us to resolve cholesterol ...
Gang Wen+3 more
wiley +1 more source
Gain of function variants in PCSK9 gene in high risk patients after myocardial infarction with increased lipoprotein (a) values and treated with statins. [PDF]
Ugovšek S+6 more
europepmc +1 more source
The nature of pre beta (very low density) lipoproteins. [PDF]
R. I. Levy+2 more
openalex +1 more source