Results 241 to 250 of about 840,133 (341)

Aptamer Engineering: Strategies for Discovering Functional Nucleic Acids for Next‐Generation Diagnostics and Biosensing

Advanced Science, EarlyView.
The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen, Ahlem Meziadi, Cyrill Brunner, Maureen McKeague, Lidija Malic, Maryam Tabrizian   +5 more
wiley   +1 more source

Alterations of lipoprotein subfractions in GH-deficient adults. [PDF]

Front Endocrinol (Lausanne)
Ratku B, Lőrincz H, Csiha S, Bíró L, Erdei A, Berta E, Ujvárosy D, Bodor M, Nagy EV, Szabó Z, Harangi M, Somodi S.   +11 more
europepmc   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

Uric acid-to-high-density lipoprotein ratio and diabetes mellitus in stroke survivors: A cross-sectional analysis of NHANES 1998 to 2018. [PDF]

Medicine (Baltimore)
Zhu Y, Zhu Z, He W, Wang M, Yang W.
europepmc   +1 more source

Triglyceride to High Density Lipoprotein-Cholesterol Ratio as Predictor of Cardiometabolic Risk among Doctors

, 2019
Miliva Mozaffor, Md. Matiur Rahman
openalex   +2 more sources

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, EarlyView.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source

Effects of a two-week modified ketogenic diet on circulating lipoprotein subclasses, GDF15, and FGF21 in obese adults. [PDF]

J Transl Med
Zhang N, Liu N, Zhao G, Yan J, Zhang P, Li X, Zhou J.   +6 more
europepmc   +1 more source

Stimulatory effects of low density lipoprotein on catecholamine synthesis in cultured bovine adrenal medullary cells

, 1999
Koji Kajiwara, Nobuyuki Yanagihara, Masato Tsutsui, Yumiko Toyohira, Yasuhito Uezono, Yasuhide Nakashima, Futoshi Izumi   +6 more
openalex   +1 more source

Macrophagic Sclerostin Loop2‐ApoER2 Interaction Required by Sclerostin for Cardiovascular Protective Action

Advanced Science, EarlyView.
Sclerostin loop2‐ApoER2 interaction in macrophages is required by sclerostin to suppress NF‐κB nuclear translocation and phosphorylation, to promote macrophage conversion into anti‐inflammatory subtypes in atherosclerotic aortas, as well as to prevent atherosclerosis and aortic aneurysm development in ApoE−/− mice. Abstract Therapeutic antibody against
Luyao Wang, Xiaohui Tao, Ning Zhang, Xin Yang, Hewen Jiang, Xiaofei Li, Shenghang Wang, Shijian Ding, Sifan Yu, Huarui Zhang, Yihao Zhang, Nanxi Li, Haitian Li, Zhanghao Li, Xiaoxin Wen, Meiheng Sun, Chuanxin Zhong, Jin Liu, Yuanyuan Yu, Xianghang Luo, Tao Zhang, Shu Zhang, Péter Ferdinandy, Yu Huang, Daqing Ma, Aiping Lu, Baoting Zhang, Ge Zhang   +27 more
wiley   +1 more source

Pro‑inflammatory insulin‑resistant lipid phenotype in down syndrome identified by ¹H‑NMR metabolomics in obesity-matched African‑American children and young adults. [PDF]

Sci Rep
Qu HQ, Connolly JJ, Eister G, Mentch F, Glessner J, Hakonarson H.   +5 more
europepmc   +1 more source