Results 271 to 280 of about 840,133 (341)

Modeling chronic periodontitis in rats: Persistent alveolar bone loss mediated by periodontal pathogens

Animal Models and Experimental Medicine, EarlyView.
Irrigation of periodontal pockets with human periopathogens, in combination with a 14‐day ligature‐induced periodontitis protocol, significantly enhances alveolar bone loss and sustains bacterial colonization for up to 28 days following ligature removal, thereby more closely replicating the chronic nature of human periodontitis compared to the ligature
Maksym Skrypnyk, Chun Xu, Shlomo Berkovsky, Thilini Jayasinghe, Axel Spahr   +4 more
wiley   +1 more source

Causal effects of glutamine and lipid-related metabolites on alopecia areata: A 2-sample Mendelian randomization study. [PDF]

Medicine (Baltimore)
Yang XS, Dai R, Miao YJ, Chen SZ, Lv ZF.
europepmc   +1 more source

Innovative insights into the effects of a high‐sucrose diet on pancreatic health and the therapeutic role of empagliflozin in type 2 diabetes: An experimental study

Animal Models and Experimental Medicine, EarlyView.
Histologic assessment of pancreatic tissues using the H&E method (Scale bar = 100 μm. Images were captured at 400×). A high‐sucrose diet induced structural damage in pancreatic tissue, whereas empagliflozin treatment markedly improved these histological alterations.
Emad Gholami, Ali Fardin, Fazeleh Iranshahi, Alireza Malek, Ali Saravani, Faranaz Aghvami, Houman Parsaei, Habib Yaribeygi   +7 more
wiley   +1 more source

Differential NMR Lipoprotein Profiles and Prediction of Insulin Resistance and Metabolic Syndrome by LP-IR Among Adult Chronic Hepatitis B Patients. [PDF]

J Clin Med
Campoverde Reyes KJ, Guevara J, Karimi-Sari H, Goyes D, Lapumnuaypol K, Shah PA, Kaur SP, Connelly MA, Jiang ZG, Lau DT.   +9 more
europepmc   +1 more source

Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9

Animal Models and Experimental Medicine, EarlyView.
We established the first conditional knockout (cKO) model in the golden Syrian hamster by CRISPR/Cas9‐mediated genome editing. Cas9 protein, two sgRNAs, and a donor plasmid carrying loxP‐flanked exon 2 of the ApoF gene were microinjected into one‐cell embryos. The floxed allele was efficiently generated (up to 27%) and transmitted through the germline.
Wei Chen, Xu Zhang, Rui Fan, Xia Li, Feifei Guan, Gefan Wan, Weining Kong, Xiaolong Qi, Shuo Pan, Sijing Shi, Yuanlong Su, Shan Gao, Wei Huang, Xunde Xian, Jiangning Liu, Yuhui Wang, Yuanwu Ma   +16 more
wiley   +1 more source

Understanding lipidomics associations and the lipoprotein-related caveats in population epidemiology. [PDF]

Am J Epidemiol
Zhao S, Ohukainen P, Kettunen J, Järvelin MR, Kähönen M, Lehtimäki T, Viikari J, Raitakari OT, Mäkinen VP, Ala-Korpela M.   +9 more
europepmc   +1 more source

Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Have Distinct Prediagnostic Blood Biochemical Profiles

Annals of Neurology, EarlyView.
Objective Identifying modifiable factors influencing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) risk is important for prevention. Blood biomarkers, particularly cholesterol, have been associated with neurodegenerative risk, but findings in ALS are inconsistent, and data on FTD are limited.
Christos V. Chalitsios, Jiali Gao, Carol A.C. Coupland, Julia Hippisley Cox, Martin R. Turner, Alexander G. Thompson   +5 more
wiley   +1 more source

Lipoprotein(a) prevalence trends in Portuguese children and adolescents: a real-world perspective. [PDF]

Clin Exp Pediatr
Ribeiro IM, Vieira S, Saraiva M, Tavares M, Oliveira JC, Palma IM, Mansilha HF.   +6 more
europepmc   +1 more source

Hydroxycarboxylic Acid Receptor 2 Mediates β‐hydroxybutyrate's Antiseizure Effect in Mice

Annals of Neurology, EarlyView.
A Objective The ketogenic diet, a high‐fat, low‐carbohydrate regimen, is often used to treat drug‐resistant seizures and is being studied for Alzheimer's disease and other neuropsychiatric disorders. However, its mechanism of action remains unclear. β‐hydroxybutyrate, a primary circulating ketone body produced by the ketogenic diet, may mediate its ...
Soudabeh Naderi, John Williamson, Huayu Sun, Suchitra Joshi, Rachel Jane Spera, Savaira Zaib, Supriya Sharma, Chengsan Sun, Andrey Brodovskiy, Ifrah Zawar, Jaideep Kapur   +10 more
wiley   +1 more source

Metabolism‐Regulating Nanomedicines for Cancer Therapy

Advanced NanoBiomed Research, EarlyView.
This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley   +1 more source