Results 91 to 100 of about 2,885,946 (243)

Paternal Obesity‐Induced H3K27me3 Elevation Leads to MANF‐Mediated Transgenerational Metabolic Dysfunction in Female Offspring

Advanced Science, EarlyView.
Paternal lifestyle and environmental exposures play a critical role in the offspring's health. The present study established a paternal obesity model and demonstrated that elevated H3K27me3 levels in sperm persist through the 8‐cell embryo stage. This epigenetic modification triggers transgenerational decrease of MANF, inducing ER stress and activating
Yajun Shi, Weisheng Li, Xi Yu, Yan Zhao, Dan Zhu, Yueyang Song, Zejun Zhao, Yannan Gu, Bin Wei, Lingjun Li, Dongyi Yu, Pengjie Zhang, Qinqin Gao, Miao Sun   +13 more
wiley   +1 more source

Genomic characterization reveals distinct mutation landscapes and therapeutic implications in neuroendocrine carcinomas of the gastrointestinal tract

Cancer Communications, Volume 42, Issue 12, Page 1367-1386, December 2022., 2022
Abstract Background Neuroendocrine carcinomas of the gastrointestinal tract (GI‐NECs) remain a disease of grim prognosis with limited therapeutic options. Their molecular characteristics are still undefined. This study aimed to explore the underlying genetic basis and heterogeneity of GI‐NECs.
Huanwen Wu, Zicheng Yu, Yueping Liu, Lei Guo, Lianghong Teng, Lingchuan Guo, Li Liang, Jing Wang, Jie Gao, Ruiyu Li, Ling Yang, Xiu Nie, Dan Su, Zhiyong Liang   +13 more
wiley   +1 more source

Blood lipoproteins shape the phenotype and lipid content of early atherosclerotic lesion macrophages: a dual-structured mathematical model [PDF]

arXiv
Macrophages in atherosclerotic lesions exhibit a spectrum of behaviours or phenotypes. The phenotypic distribution of monocyte-derived macrophages (MDMs), its correlation with MDM lipid content, and relation to blood lipoprotein densities are not well understood.
arxiv  

Decoding Blastocystis‐Driven Mechanisms in Gut Microbiota and Host Metabolism

Advanced Science, EarlyView.
Blastocystis, a prevalent gut microbe, interacts with the host through metabolic and immune pathways, influencing cardiometabolic health. This perspective explores its role in modulating short‐chain fatty acid production, tryptophan metabolism, and immune signaling, potentially impacting cholesterol absorption, glucose metabolism, and vascular health ...
Lei Deng, Kevin SW Tan
wiley   +1 more source

RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development

Advanced Science, EarlyView.
The study investigates the role of RACK7 in brain development using a conditional knockout mouse model. RACK7 deficiency results in developmental defects and abnormal astrocyte development by disrupting H3K27me3 chromatin binding. The underlying mechanism involves RACK7 interacting with the PRC2 complex to regulate the genomic localization of SUZ12 and
Fangfang Jiao, Tianxiang Tang, Bowen Wang, Shengfei He, Yue Zhang, Li Dong, Bo Xu, Ying Liu, Ping Zhu, Rui Guo   +9 more
wiley   +1 more source

Bayesian modelling for binary outcomes in the Regression Discontinuity Design [PDF]

arXiv, 2016
The Regression Discontinuity (RD) design is a quasi-experimental design which emulates a randomised study by exploiting situations where treatment is assigned according to a continuous variable as is common in many drug treatment guidelines. The RD design literature focuses principally on continuous outcomes.
arxiv  

Host Plasma Microenvironment in Immunometabolically Impaired HIV Infection Leads to Dysregulated Monocyte Function and Synaptic Transmission Ex Vivo

Advanced Science, EarlyView.
Network‐based risk stratification of people living with HIV (PWH) on prolonged therapy using multi‐omics data identifies 44% of the patients are at risk of immunometabolic complications. A senescence‐associated myeloid cell‐driven plasma microenvironment drives immunometabolic dysregulation in at‐risk PWH.
Flora Mikaeloff, Marco Gelpi, Alejandra Escós, Tianqi Wang, Soham Gupta, Anna Olofsson, Sara Svensson Akusjärvi, Sabrina Schuster, Prajakta Naval, Vikas Sood, Negin Nikouyan, Andreas D. Knudsen, Beate Vestad, Julie Høgh, Johannes R. Hov, Thomas Benfield, Marius Trøseid, Vinay Pawar, Marijana Rucevic, Rui Benfeitas, Ákos Végvári, Liam O'Mahony, Rajkumar Savai, Niklas K. Björkström, Magda Lourda, João Pedro de Magalhães, Siegfried Weiss, Adil Mardinoglu, Mukesh Kumar Varshney, Annika C. Karlsson, Yasir Ahmed Syed, Susanne D. Nielsen, Ujjwal Neogi   +32 more
wiley   +1 more source

Contextualizing selection bias in Mendelian randomization: how bad is it likely to be? [PDF]

arXiv, 2018
Selection bias affects Mendelian randomization investigations when selection into the study sample depends on a collider between the genetic variant and confounders of the risk factor-outcome association. However, the relative importance of selection bias for Mendelian randomization compared to other potential biases is unclear.
arxiv  

Lipoprotein(a) in chronic renal failure [PDF]

Journal of Medical Biochemistry, 2009
Cardiovascular diseases are the leading cause of mortality in patients with chronic renal failure. Among the parameters contributing to cardiovascular disease development is the elevated serum concentration of lipoprotein(a) diagnosed in these patients ...
Čabarkapa Velibor, Đerić Mirjana, Stošić Zoran, Sakač Vladimir, Kojić-Damjanov Sunčica, Eremić Nevena   +5 more
doaj  

Engineering Extracellular Vesicles Derived from 3D Cultivation of BMSCs Enriched with HGF Ameliorate Sepsis‐Induced Lung Epithelial Barrier Damage

Advanced Science, EarlyView.
3D culture of MSCs upregulates gene expression of matrix metalloproteinases (MMPs), growth factors (GFs), and increases the production of extracellular vesicles (EVs). Proteomic analysis reveals 642 upregulated proteins in 3D‐EVs, including HGF. These 3D‐EVs, enriched with HGF, protect lung epithelial cells from apoptosis and barrier damage in septic ...
Yong Chen, Feihong Lin, Tong Zhang, Zhuoran Xiao, Yuanli Chen, Dongsheng Hua, Yu Wang, Juan Wei, Tian Jin, Xin Lv   +9 more
wiley   +1 more source