Results 81 to 90 of about 442,632 (268)

Cholesterol Laundry of Cell Membrane and Fatty Liver by Detergent Liposomes to Improve Anti‐Cancer Drug Responsiveness of Patient Liver Tissues

Advanced Science, EarlyView.
Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim, Joo Kyung Noh, Sewoom Baek, Seung Eun Yu, Jueun Kim, Seongyo Lee, Youngji Oh, Dai Hoon Han, Seyong Chung, Hak‐Joon Sung   +9 more
wiley   +1 more source

Lipoproteína (a): estructura, metabolismo, genética y mecanismos patogénicos

Revista Cubana de Investigaciones Biomédicas, 2003
Se establecieron las características más sobresalientes de la lipoproteína (a), así como los mecanismos patogénicos de esta partícula lipoproteínica relacionados con la aterotrombogénesis.
Lázaro E. Alba Zayas, Giovanna Pereira Roca, Arístides Aguilar Betancourt   +2 more
doaj  

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

Association of Butyryl Cholinesterase and Recurrent Ischemic Stroke: A Cross-Sectional Study

International Journal of General Medicine
Ruomeng Chen,1,2 Kun Zhang,1,2 Hui Liu,1,2 Lijuan Liu,1,2 Hui Li,3 Yan Yan,1,2 Zhou Zhou,1,2 Chaoyue Meng,1,2 Xuelin Wang,4 Haoran Wu,4 Ruihan Miao,4 Rui Wang,1,2 Xiaoyun Liu1,2,4,5 1Department of Neurology, The First Hospital of Hebei Medical University,
Chen R, Zhang K, Liu H, Liu L, Li H, Yan Y, Zhou Z, Meng C, Wang X, Wu H, Miao R, Wang R, Liu X   +12 more
doaj  

SERUM LIPOPROTEIN (a) LEVELS IN HEMODIALYSIS PATIENTS

Turkish Journal of Nephrology, 2019
İn our hemodialysis center, serum Lipoprotein (a) {Lp(a)j, Apoprotein Ai (ApoAi) and Apoprotein B (Apo B) levels were examined in 50 patients and 50 healthy controls.
Mahmut YAVUZ, Mustafa GÜLLÜLÜ, Alpaslan ERSOY, Kamil DİLEK, Mustafa YURTKURAN   +4 more
doaj  

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Lipoprotein (a) Testing in Patients With Atherosclerotic Cardiovascular Disease in 5 Large US Health Systems

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Lipoprotein (a) is an independent risk factor for atherosclerotic cardiovascular disease. However, lipoprotein (a) testing remains variable and it is unclear what factors influence testing and if testing changes clinical management.
Nishant P. Shah, Hillary Mulder, Elizabeth Lydon, Karen Chiswell, Xingdi Hu, Zachary Lampron, Lauren Cohen, Manesh R. Patel, Susan Taubes, Wenliang Song, Suresh R. Mulukutla, Anum Saeed, Daniel P. Morin, Steven M. Bradley, Adrian F. Hernandez, Neha J. Pagidipati   +15 more
doaj   +1 more source

Lipoprotein(a) [PDF]

Clinical Research in Cardiology Supplements, 2019
K P, Mellwig, A, Vogt
openaire   +2 more sources

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source