Results 31 to 40 of about 2,901,963 (145)
Geometric and Electromagnetic Aspects of Fusion Pore Making [PDF]
Systems Biology 2 (2011), pp. 505-538, 2009 For regulated exocytosis, we model the morphology and dynamics of the making of the fusion pore or porosome as a cup-shaped lipoprotein structure (a dimple or pit) on the cytosol side of the plasma membrane. We describe the forming of the dimple by a free boundary problem.
arxiv +1 more source
Oxysterols in Vascular Cells and Role in Atherosclerosis [PDF]
Implication of Oxysterols and Phytosterols in Aging and Human
Diseases, 1440, Springer International Publishing, pp.213-229, 2024, Advances
in Experimental Medicine and BiologyAtherosclerosis is a major cardiovascular complication of diseases associated with elevated oxidative stress such as type 2 diabetes and metabolic syndrome. In these situations, low density lipoproteins (LDL) undergo oxidation. Oxidized LDL display proatherogenic activities through multiple and complex mechanisms which lead to dysfunctions of vascular ...
arxiv +1 more source
Biophysicochemical interaction of a clinical pulmonary surfactant with nano-alumina [PDF]
Langmuir 31 (26) 7346 - 7354 (2015), 2015 We report on the interaction of pulmonary surfactant composed of phospholipids and proteins with nanometric alumina (Al2O3) in the context of lung exposure and nanotoxicity. We study the bulk properties of phospholipid/nanoparticle dispersions and determine the nature of their interactions.
arxiv +1 more source
iScience, 2023 Summary: Very-long-chain polyunsaturated fatty acids (VLCPUFAs; C24-38) constitute a unique class of PUFA that have important biological roles, but the lack of a suitable dietary source has limited research in this field.
Zhi-Hong Yang +21 more
doaj
Lipids in Health and Disease, 2023 Background & aims Apolipoproteins and lipoprotein(a) are associated with various cardiometabolic diseases, including insulin resistance, diabetes mellitus, hypertension, dyslipidemia, among others.
Juan R. Ulloque-Badaracco +8 more
doaj +1 more source
A Dynamical Model of Lipoprotein Metabolism [PDF]
arXiv, 2006 We present a dynamical model of lipoprotein metabolism derived by combining a cascading process in the blood stream and cellular level regulatory dynamics. We analyse the existence and stability of equilibria and show that this low-dimensional, nonlinear model exhibits bistability between a low and a high cholesterol state.
arxiv
Modelling the inflammatory process in atherosclerosis: a nonlinear renewal equation [PDF]
arXiv, 2017 We present here a population structured model to describe the dynamics of macrophage cells. The model involves the interactions between modified LDL, monocytes/macrophages, cytokines and foam cells. The key assumption is that the individual macrophage dynamics depends on the amount of lipoproteins it has internalized.
arxiv
Effect of hypertension on low-density lipoprotein transport within a multi-layered arterial wall: modelling consistent with experiments [PDF]
arXiv, 2016 The influence of hypertension on low-density lipoproteins intake into the arterial wall is an important factor for understanding mechanisms of atherosclerosis. It has been experimentally observed that the increased pressure leads to the higher level of the LDL inside the wall.
arxiv
Contemporary patterns of lipoprotein(a) testing and associated clinical care and outcomes
American Journal of Preventive Cardiology, 2023 Objective: Elevated lipoprotein(a) [Lp(a)] is associated with atherosclerotic cardiovascular disease, yet little is known about Lp(a) testing patterns in real-world practice.
Michelle D. Kelsey +18 more
doaj
Two Robust Tools for Inference about Causal Effects with Invalid Instruments [PDF]
arXiv, 2020 Instrumental variables have been widely used to estimate the causal effect of a treatment on an outcome. Existing confidence intervals for causal effects based on instrumental variables assume that all of the putative instrumental variables are valid; a valid instrumental variable is a variable that affects the outcome only by affecting the treatment ...
arxiv