Results 61 to 70 of about 2,885,946 (243)
Advanced Materials, EarlyView.A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen +7 more
wiley +1 more source
Frontiers in Cardiovascular MedicineBackgroundMultiple guidelines recommend detection of and early risk factor management for elevated lipoprotein(a) [Lp(a)]. Effective implementation requires assessment of knowledge and practices regarding elevated Lp(a) among medical specialists.AimTo ...
Wann Jia Loh +7 more
doaj +1 more source
Adjusting Cell‐Surface Interactions Through a Covalent Immobilization of Biomolecules
Advanced Materials Interfaces, EarlyView.This review presents an overview of current and emerging immobilization techniques coupled with an in‐depth investigation of the underlying mechanisms governing the activity and stability of covalently immobilized biomolecules. The aim of this study is to serve as a guide for the development of long‐lasting biomedical coatings with versatile biological
Sara Shakibania +2 more
wiley +1 more source
Stability of discoidal high-density lipoprotein particles [PDF]
arXiv, 2013 Motivated by experimental and numerical studies revealing that discoidal high-density lipoprotein (HDL) particles may adopt flat elliptical and nonplanar saddle-like configurations, it is hypothesized that these might represent stabilized configurations of initially unstable flat circular particles. A variational description is developed to explore the
arxiv
A Latent Mixture Model for Heterogeneous Causal Mechanisms in Mendelian Randomization [PDF]
arXiv, 2020 Mendelian Randomization (MR) is a popular method in epidemiology and genetics that uses genetic variation as instrumental variables for causal inference. Existing MR methods usually assume most genetic variants are valid instrumental variables that identify a common causal effect.
arxiv
Advanced Science, EarlyView.By decreasing cholesterol and lipid raft levels in the plasma membrane, proprotein convertase subtilisin/kexin type 9 (PCSK9) boosts human epidermal growth factor receptor 1 and 3 (EGFR and HER3) activation, driving tumor growth and metastasis in triple‐negative breast cancer (TNBC).
Tianhong Li, Renfei Wu, Kathy Qian Luo
wiley +1 more source
Regression with a right-censored predictor, using inverse probability weighting methods [PDF]
arXiv, 2020 In a longitudinal study, measures of key variables might be incomplete or partially recorded due to drop-out, loss to follow-up, or early termination of the study occurring before the advent of the event of interest. In this paper, we focus primarily on the implementation of a regression model with a randomly censored predictor.
arxiv
Nanotherapy for Neural Retinal Regeneration
Advanced Science, EarlyView.Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu +11 more
wiley +1 more source
Pathways-driven Sparse Regression Identifies Pathways and Genes Associated with High-density Lipoprotein Cholesterol in Two Asian Cohorts [PDF]
arXiv, 2013 Standard approaches to analysing data in genome-wide association studies (GWAS) ignore any potential functional relationships between genetic markers. In contrast gene pathways analysis uses prior information on functional structure within the genome to identify pathways associated with a trait of interest. In a second step, important single nucleotide
arxiv
Spectral Analysis and Invariant Measure in Studies of the Dynamics of the Hemostasis of a Blood Vessel [PDF]
Ukrainian Journal of Physics, 2021, 66(3), 221A mathematical model of atherosclerosis of a blood vessel is advanced with regard for the entry of low-density lipoproteins (LDLs) into blood. For the first time, the influence of cytokines on the inflammation of a blood vessel at the formation of atherosclerotic plaques is taken into account.
arxiv +1 more source