Results 71 to 80 of about 801,768 (340)

Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Apolipoprotein ε4 (APOE ε4) is a potent genetic risk factor for Alzheimer's disease (AD). However, its role in cerebral small vessel disease (CSVD) remains unclear. Given the clinical and pathological similarities between CSVD and AD, this study aimed to investigate the associations of APOE ε4 gene dosage with cognitive function and
Tingru Jin, Haocheng Yang, Feng Liu, Sihao Lin, Junru Hu, Jian Wang, Yulan Gou   +6 more
wiley   +1 more source

Real-world impact of transitioning from one lipoprotein(a) assay to another in a clinical setting

American Journal of Preventive Cardiology
Background and aims: Different lipoprotein(a) [Lp(a)] assays may affect risk stratification of individuals and thus clinical decision-making. We aimed to investigate how transitioning between Lp(a) assays at a large central laboratory affected the ...
Janeni Jeevanathan, Sigrid M. Blom, Thomas Olsen, Kirsten B. Holven, Erik K. Arnesen, Torleif Trydal, Børge G. Nordestgaard, Michael Sovershaev, Ying Chen, Kjetil Retterstøl, Jacob J. Christensen   +10 more
doaj   +1 more source

High plasma leptin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidised lipids. [PDF]

, 2011
BackgroundPatients with systemic lupus erythematosus (SLE) are at increased risk of atherosclerosis, even after accounting for traditional risk factors.
Charles-Schoeman, Christina, Chernishof, Marissa, FitzGerald, John, Gorn, Alan, Grossman, Jennifer, Hahn, Bevra H, La Cava, Antonio, McMahon, Maureen, Ragavendra, Nagesh, Sahakian, Lori, Skaggs, Brian J, Wallace, Daniel J, Weisman, Michael, Witztum, Joseph L, Wong, Weng Kee   +14 more
core   +2 more sources

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

Lipoprotein(a) throughout life in women

American Journal of Preventive Cardiology
Lipoprotein (a) [Lp(a)] is a lipoprotein with multiple deleterious characteristics and is a recognized cardiovascular (CV) risk factor. The pro-atherogenic, pro-thrombotic, and pro-inflammatory features of Lp(a) are associated not only with ...
Pablo Corral, María Gabriela Matta, Carlos Aguilar-Salinas, Roopa Mehta, Gabriela Berg, Massimiliano Ruscica, Laura Schreier   +6 more
doaj   +1 more source

Fibrinogen Changes Before and After Intravenous Thrombolysis as Predictors of Cerebral Injury and Clinical Outcomes in Acute Ischemic Stroke: A Multicenter Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma fibrinogen is essential in thrombosis and fibrinolysis, yet its dynamic changes pre‐ and post‐intravenous thrombolysis (IVT) for predicting brain injury severity and prognosis in acute ischemic stroke (AIS) patients remain unclear.
Wenhai Zhai, Yang Qu, Reziya Abuduxukuer, Kejia Zhang, Peng Zhang, Xin Tang, Huaimei Zhang, Lijuan Wang, Lichong Yang, Shuangxu Tan, Zhimei Yuan, Ce Han, Lili He, Yuping Zheng, Fenglan Zhao, Lijie Guo, Ligang Jiang, Jinfeng Li, Yongfei Jiang, Xuexia Zou, Dan Xu, Han Xu, Xiaojia Wang, Yingbin Qi, Xuefeng Hu, Yu Zhang, Zhen‐Ni Guo, Hang Jin, on behalf of the Biomarkers of Brain Injury Investigator Study Group   +28 more
wiley   +1 more source

Lipoprotein(a) and the atherosclerotic burden – Should we wait for clinical trial evidence before taking action?

Atherosclerosis Plus
The fact that lipoprotein(a) levels should be regarded as a causal residual risk factor in the atherosclerotic cardiovascular diseases (ASCVD) is now a no-brainer.
Isabella Fichtner, Chiara Macchi, Alessandra Stefania Rizzuto, Stefano Carugo, Alberto Corsini, Massimiliano Ruscica   +5 more
doaj   +1 more source

The Effects of Temulawak extract and Yoghurt on HDL-LDL mice blood exposed waste cooking oil [PDF]

, 2015
Using cooking oil repeatedly in processing the fried foods can cause health problems, especially cholesterol metabolism that affect levels of HDL, LDL, triglycerides and total cholesterol blood that can cause blockage of blood vessels leading
Alipin, Kartiawati, Kuntana, Yasmi Purnamasari, Tanzania, Walida   +2 more
core  

A simple method to assess the oxidative susceptibility of low density lipoproteins [PDF]

, 2001
BACKGROUND: Oxidative modification of low density lipoproteins (LDL) is recognized as one of the major processes involved in atherogenesis. The in vitro standardized measurement of LDL oxidative susceptibility could thus be of clinical significance.
A Lavy, B Guerci, B Wallin, C Coudray, CJ Schwartz, D Steinberg, D Steinbergt, H Esterbauer, H Esterbauer, H Ohkawa, JA Buege, JM Brun, M El-Saadani, M Taus, MA Moss, MAQ Arshad, MM Bradford, N Rifai, PN Demacker, TJ Lyons   +19 more
core   +4 more sources

Native and Oxidized Low-Density Lipoproteins Increase the Expression of the LDL Receptor and the LOX-1 Receptor, Respectively, in Arterial Endothelial Cells [PDF]

, 2022
Rusan Catar, Lei Chen, Hongfan Zhao, Dashan Wu, Julian Kamhieh‐Milz, Christian Lücht, Daniel Zickler, Alexander W. Krug, Christian G. Ziegler, Henning Morawietz, Janusz Witowski   +10 more
openalex   +1 more source