Associations of physical activity and sedentary time with lipoprotein subclasses in Norwegian schoolchildren: The Active Smarter Kids (ASK) study [PDF]
Background and aims: Physical activity is favourably associated with certain markers of lipid metabolism. The relationship of physical activity with lipoprotein particle profiles in children is not known.
Aadland, Eivind+9 more
core +2 more sources
The role of metformin response in lipid metabolism in patients with recent-onset type 2 diabetes: HbA1c level as a criterion for designating patients as responders or nonresponders to metformin [PDF]
Background: In this study, we investigated whether response to metformin, the most frequently drug for diabetes treatment, influences the therapeutic effects of antilipidemic medication in newly diagnosed patients with type 2 diabetes mellitus (T2DM ...
Alizadeh, A.+3 more
core +6 more sources
Causal Models with Constraints [PDF]
Causal models have proven extremely useful in offering formal representations of causal relationships between a set of variables. Yet in many situations, there are non-causal relationships among variables. For example, we may want variables $LDL$, $HDL$, and $TOT$ that represent the level of low-density lipoprotein cholesterol, the level of lipoprotein
arxiv
Metabolism of low-density lipoproteins by cultured hepatocytes from normal and homozygous familial hypercholesterolemic subjects [PDF]
The profoundly elevated concentrations of low-density lipoproteins (LDL) present in homozygous familial hypercholesterolemia lead to symptomatic cardiovascular disease and death by early adulthood.
Brewer, HB+6 more
core +1 more source
Oxysterols in Vascular Cells and Role in Atherosclerosis [PDF]
Atherosclerosis is a major cardiovascular complication of diseases associated with elevated oxidative stress such as type 2 diabetes and metabolic syndrome. In these situations, low density lipoproteins (LDL) undergo oxidation. Oxidized LDL display proatherogenic activities through multiple and complex mechanisms which lead to dysfunctions of vascular ...
arxiv +1 more source
A comparative study of the lipid panel levels at different duration time and temperature storage [PDF]
Background: the stability of serum specimen during time storage is importance in clinical and medical science researches in addition of diagnosis. Lipids are organic molecules that classified into 8 classes: fatty acids, phospholipids, glycerolipids, saccharolipids, polyketides, prenol lipids, sterol, and sphingolipids.
arxiv
Mass Conservation And Inference of Metabolic Networks from High-throughput Mass Spectrometry Data [PDF]
We present a step towards the metabolome-wide computational inference of cellular metabolic reaction networks from metabolic profiling data, such as mass spectrometry. The reconstruction is based on identification of irreducible statistical interactions among the metabolite activities using the ARACNE reverse-engineering algorithm and on constraining ...
arxiv +1 more source
Lipoprotein Metabolism in Pregnancy
The purpose of this review is to consider the alterations occurring in lipoprotein metabolism in human pregnancy and in selected animal models and to attempt to understand the reasons for these changes and the possible significance for maternal physiology and fetal growth and development.
Knopp, Robert H.+4 more
openaire +2 more sources
Dydrogesterone and norethisterone regulate expression of lipoprotein lipase and hormones-sensitive lipase in human subcutaneous abdominal adipocytes [PDF]
Aim: In premenopausal women, hyper-androgenicity is associated with central obesity and an increased cardiovascular risk. We investigated the effects of dydrogesterone (DYD)(a non-androgenic progestogen) and norethisterone (NET)(an androgenic progestogen)
Barnett, A. H.+5 more
core +1 more source
Biological, clinical and population relevance of 95 loci for blood lipids. [PDF]
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic ...
Aulchenko, Yurii S+99 more
core