Metabolic graphs, LIFE method and the modeling of drug action on Mycobacterium tuberculosis [PDF]
arXiv, 2020 This paper serves as a framework for designing advanced models for drug action on metabolism. Drug treatment may affect metabolism by either enhancing or inhibiting metabolic reactions comprising a metabolic network. We introduce the concept of \textit{metabolic graphs}, a generalization of hypergraphs having specialized features common to metabolic ...
arxiv
A system-wide network reconstruction of gene regulation and metabolism in Escherichia coli [PDF]
, 2018 Genome-scale metabolic models have become a fundamental tool for examining metabolic principles. However, metabolism is not solely characterized by the underlying biochemical reactions and catalyzing enzymes, but also affected by regulatory events. Since the pioneering work of Covert and co-workers as well as Shlomi and co-workers it is debated, how ...
arxiv +1 more source
Astrocytic LRP1 mediates brain Aβ clearance and impacts amyloid deposition [PDF]
, 2017 Accumulation and deposition of amyloid-β (Aβ) in the brain represent an early and perhaps necessary step in the pathogenesis of Alzheimer's disease (AD).
Bu, Guojun +8 more
core +2 more sources
The metabolism of lipoprotein (a): an ever-evolving story
Journal of Lipid Research, 2017 Lipoprotein (a) [Lp(a)] is characterized by apolipoprotein (a) [apo(a)] covalently bound to apolipoprotein B 100. It was described in human plasma by Berg et al.
Gissette Reyes-Soffer +2 more
doaj
Bifurcation analysis of a free boundary model of plaque formation associated with the cholesterol ratio [PDF]
arXiv, 2020 The low-density lipoprotein (LDL)/high-density lipoprotein (HDL)-cholesterol ratio has been shown a high correlation with the cardiovascular risk assessment. Is it possible to quantify the correlation mathematically? In this paper, we develop a bifurcation analysis for a mathematical model of the plaque formation with a free boundary in the early stage
arxiv
Genetic obesity increases pancreatic expression of mitochondrial proteins which regulate cholesterol efflux in BRIN-BD11 insulinoma cells [PDF]
, 2019 Pancreatic β-cells are sensitive to fluctuations in cholesterol content, which can damage the insulin secretion pathway, contributing to the aetiology of type 2 diabetes mellitus.
Caridis, Anna Maria +4 more
core +1 more source
Postprandial lipoprotein metabolism and atherosclerosis [PDF]
Journal of Internal Medicine, 1999 Abstract. Karpe F. (Karolinska Hospital, Stockholm, Sweden; and Radcliffe Infirmary, Oxford, England, UK). Postprandial lipoprotein metabolism and atherosclerosis (Review). J Intern Med 1999; 246: 341–355.Postprandial lipids and lipoproteins have been associated with the presence of cardiovascular disease in a large number of case‐control studies ...
openaire +4 more sources
Deficient Cholesterol Esterification in Plasma of apoc2 Knockout Zebrafish and Familial Chylomicronemia Patients. [PDF]
, 2017 Hypertriglyceridemia is an independent risk factor for cardiovascular disease. Apolipoprotein C-II (APOC2) is an obligatory cofactor for lipoprotein lipase (LPL), the major enzyme catalyzing plasma triglyceride hydrolysis.
Gaudet, Daniel +2 more
core +1 more source
Journal of Lipid Research, 2000 Hepatic lipase (HL) is a key player in lipoprotein metabolism by modulating, through its lipolytic activity, the triglyceride (TG) and phospholipid content of apolipoprotein B (apoB)-containing lipoproteins and of high density lipoproteins (HDL), thereby
Alberto Zambon +4 more
doaj
PCSK9: BIOLOGICAL ACTIVITY REGULATION AND CONNECTION WITH LIPID AND CARBOHYDRATE METABOLISM
Клиническая практика, 2017 Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease which plays an important role in the regulation of LDL receptor (LDLR) expression and apolipoprotein B (apoB) lipoprotein cholesterol metabolism.
A O Averkova
doaj +1 more source