Results 101 to 110 of about 115,025,331 (252)

Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma

Advanced Science, EarlyView.
This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert, Christophe Nguyen, Sean Edward Dunn, Magali Gary‐Bobo, Jérôme Lacombe, Justin Moser, Frédéric Zenhausern, Jean‐Olivier Durand, Frédérique Cunin   +8 more
wiley   +1 more source

A model of human APOA2 on HDL

Journal of Lipid Research
Apolipoprotein A-II, the second most abundant protein in HDL, plays a key role in HDL maturation and reverse cholesterol transport. It has a stronger affinity for lipids than apolipoprotein A-I (APOA1), which forms HDL's structural scaffold.
Yi He, Hyun Song, Youngki You, John T. Melchior, Martin K. Jones, Stephen G. Aller, W. Sean Davidson, Jay W. Heinecke, Jere P. Segrest   +8 more
doaj   +1 more source

Circulating HDL levels control hypothalamic astrogliosis via apoA-I

Journal of Lipid Research, 2018
Meta-inflammation of hypothalamic areas governing energy homeostasis has recently emerged as a process of potential pathophysiological relevance for the development of obesity and its metabolic sequelae.
Anna Götz, Maarit Lehti, Elizabeth Donelan, Cynthia Striese, Sebastian Cucuruz, Stephan Sachs, Chun-Xia Yi, Stephen C. Woods, Samuel D. Wright, Timo D. Müller, Matthias H. Tschöp, Yuanqing Gao, Susanna M. Hofmann   +12 more
doaj   +1 more source

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Protein and cell therapy for lecithin-cholesterol acyltransferase (LCAT) deficiency [PDF]

, 2009
Lecithin-cholesterol acyltransferase (LCAT) is an enzyme principally secreted by the liver into the circulation where it esterifies cholesterol and plays a key role in high- density lipoprotein (HDL) metabolism. In familial and acquired (liver disease)
Low, J K, Low, J.K.
core  

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

From lipoprotein metabolism to blood clotting: Highlights of the 2025 Fredrickson lipid research conference

Journal of Lipid Research
The biannual Fredrickson Lipid Research conference took place in person in Milwaukee, Wisconsin, from September 3-5, 2025. Each conference highlights the most advanced basic and translational research in lipids and lipoprotein metabolism.
Alexis N. Smith, Mirza A. Beg, Woosuk Steve Hur, David Ginsburg, Iftikhar J. Kullo, Sean S. Davies, Ira Tabas, Jesse W. Williams, Chieko Mineo, Bishuang Cai, Rana K. Gupta, Jaume Amengual, Anna Schwendeman, Gregory A. Graf, Mary Sorci Thomas, Ze Zheng   +15 more
doaj   +1 more source

Polymorphisms of lipoprotein lipase gene and their participation in metabolic processes Polimorfizmy genu lipazy lipoproteinowej i ich udział w procesach metabolicznych [PDF]

Pediatric Endocrinology, Diabetes and Metabolism, 2011
Lipoprotein lipase (LPL) plays a central role in dyslipidemia and development of metabolic syndrome. The occurrence of polymorphisms of the LPL gene may result in the disturbance in the lipid metabolism and pathogenesis of CAD.
Ewa Barg, 0 0
doaj  

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source