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Clinical Case Reports, Volume 12, Issue 10, October 2024.Key Clinical Message Early recognition and management of familial hypercholesterolemia (FH) are crucial, especially in patients with extensive xanthomas and premature coronary artery disease. Prompt diagnosis and aggressive lipid‐lowering therapy can significantly reduce morbidity and mortality rates.
Harsimran Kalsi +6 more
wiley +1 more source
Journal of Lipid Research, 1990 Low density lipoproteins (LDL) have the potential to serve as cell specific drug carriers. The LDL may be derived in large quantities from LDL-apheresis procedures.
HW Schultis +3 more
doaj
Pathways-driven Sparse Regression Identifies Pathways and Genes Associated with High-density Lipoprotein Cholesterol in Two Asian Cohorts [PDF]
arXiv, 2013 Standard approaches to analysing data in genome-wide association studies (GWAS) ignore any potential functional relationships between genetic markers. In contrast gene pathways analysis uses prior information on functional structure within the genome to identify pathways associated with a trait of interest. In a second step, important single nucleotide
arxiv
Asian Journal of Transfusion Science, 2017 Familial hypercholesterolemia (FH) is an autosomal dominant disorder due to mutation of apolipoprotein-B receptor gene causing severe dyslipidemia. Lifestyle modification and medical treatment attenuate the disease progression, but as these fail to ...
Kanchan Dogra +8 more
doaj +1 more source
A Latent Mixture Model for Heterogeneous Causal Mechanisms in Mendelian Randomization [PDF]
arXiv, 2020 Mendelian Randomization (MR) is a popular method in epidemiology and genetics that uses genetic variation as instrumental variables for causal inference. Existing MR methods usually assume most genetic variants are valid instrumental variables that identify a common causal effect.
arxiv
Lipoprotein apheresis for the treatment of familial hypercholesterolemia
Clinical Lipidology, 2013 Lipoprotein apheresis involves the extracorporeal removal of LDL and lipoprotein(a) particles from whole blood or plasma by adsorption, precipitation or differential filtration. Used repetitively, this provides a safe and effective means of treating patients at high risk of premature cardiovascular mortality and morbidity from genetically determined ...
Shahenaz Walji +2 more
openaire +2 more sources
Two Robust Tools for Inference about Causal Effects with Invalid Instruments [PDF]
arXiv, 2020 Instrumental variables have been widely used to estimate the causal effect of a treatment on an outcome. Existing confidence intervals for causal effects based on instrumental variables assume that all of the putative instrumental variables are valid; a valid instrumental variable is a variable that affects the outcome only by affecting the treatment ...
arxiv
Journal of Lipid Research, 2014 Lipoprotein-apheresis (apheresis) removes LDL-cholesterol in patients with severe dyslipidemia. However, reduction is transient, indicating that the long-term cardiovascular benefits of apheresis may not solely be due to LDL removal. Microparticles (MPs)
Katherine D. Connolly +8 more
doaj
Regression with a right-censored predictor, using inverse probability weighting methods [PDF]
arXiv, 2020 In a longitudinal study, measures of key variables might be incomplete or partially recorded due to drop-out, loss to follow-up, or early termination of the study occurring before the advent of the event of interest. In this paper, we focus primarily on the implementation of a regression model with a randomly censored predictor.
arxiv
VLDL/LDL acts as a drug carrier and regulates the transport and metabolism of drugs in the body
Scientific Reports, 2017 Only free drugs have been believed to be carried into tissues through active or passive transport. However, considering that lipoproteins function as carriers of serum lipids such as cholesterol and triglycerides, we hypothesized that lipoproteins can ...
Hideaki Yamamoto +6 more
doaj +1 more source