Results 81 to 90 of about 280,456 (250)

HEART UK Consensus Statement on Lipoprotein(a) - a call to action [PDF]

, 2019
Lipoprotein(a), Lp(a), is a modified atherogenic low-density lipoprotein particle that contains apolipoprotein(a). Its levels are highly heritable and variable in the population. This consensus statement by HEART UK is based on the evidence that Lp(a) is
Byrne, Chris D, Capps, Nigel, Cegla, Jaimini, Cramb, Robert, Datta, Dev, Ferns, Gordon, for the HEART UK Medical, Scientific and Research Committee, France, Michael, Halcox, Julian, Main, Linda, Neely, R Dermot G, Paynel, Jules, Qureshi, Nadeem, Rees, Alan, Shoulder, Carol, Soran, Handrean, Viljoen, Adie   +16 more
core   +3 more sources

Identifying Red Flags in Myasthenia Gravis Diagnosis, Reassessment, and Myasthenic Crisis: An Italian Delphi‐Based Position Paper

Acta Neurologica Scandinavica, Volume 2026, Issue 1, 2026.
Background and Purpose Myasthenia gravis (MG) is a complex autoimmune disorder affecting neuromuscular transmission, often leading to diagnostic and therapeutic challenges. Timely identification of “red flags” in diagnosis, therapeutic reassessment, and myasthenic crisis is crucial to optimizing patient outcomes. This Delphi‐based consensus is aimed at
Francesco Habetswallner, Luca Bello, Fiammetta Biasini, Bernardo Maria De Martino, Fiammetta Vanoli, Paolo E. Alboini, Giovanni Antonini, Carlo Antozzi, Valentina Damato, Vincenzo Di Stefano, Amelia Evoli, Matteo Gastaldi, Raffaele Iorio, Michelangelo Maestri, Renato Mantegazza, Roberto Massa, Rita Rinaldi, Francesco Saccà, Carmelo Rodolico, Dominic B. Fee   +19 more
wiley   +1 more source

Impact of LDL apheresis on atheroprotective reverse cholesterol transport pathway in familial hypercholesterolemia

Journal of Lipid Research, 2012
In familial hypercholesterolemia (FH), low HDL cholesterol (HDL-C) levels are associated with functional alterations of HDL particles that reduce their capacity to mediate the reverse cholesterol transport (RCT) pathway.
Alexina Orsoni, Elise F. Villard, Eric Bruckert, Paul Robillard, Alain Carrie, Dominique Bonnefont-Rousselot, M. John Chapman, Geesje M. Dallinga-Thie, Wilfried Le Goff, Maryse Guerin   +9 more
doaj   +1 more source

Ovarian Aging: Mechanisms, Age‐Related Disorders, and Therapeutic Interventions

MedComm, Volume 6, Issue 12, December 2025.
A comprehensive overview of the molecular mechanisms underlying ovarian aging, its association with age‐related diseases, and potential therapeutic interventions. Ovarian aging involves DNA damage, mitochondrial dysfunction, oxidative stress, telomere attrition, and follicular depletion, driving age‐related infertility, menopause, and multiple systemic
Xingyu Liu, Yuanqu Zhao, Yanzhi Feng, Shixuan Wang, Jinjin Zhang   +4 more
wiley   +1 more source

Plasmapheresis in Acute Hypertriglyceridemia‐Induced Pancreatitis—The PHIP‐JuGa‐Study

United European Gastroenterology Journal, Volume 13, Issue 10, Page 2066-2074, December 2025.
ABSTRACT Background and Aims The incidence of acute pancreatitis is increasing in the Western world. About 10% of cases are caused by hypertriglyceridemia. Plasmapheresis was shown to reduce serum triglyceride (TG) levels, and current apheresis guidelines recommend its use in severe acute hypertriglyceridemia‐induced pancreatitis (HIP).
Jonas J. Staudacher, Elisabeth Blüthner, Katharina Murillo, Manja Boldt, Karim Hamesch, Leah Kruse, Sabrina Sulzer, Christoph Ammer‐Herrmenau, Yvonne Huber, Julia Weinmann‐Menke, Charlotte Kramer, Jakob Garbe, Rene Wilke, Marcus M. Mücke, Myriam W. Heilani, Elisabeth Orgler‐Gasche, Marlies Vornhülz, Georg Beyer, Lara Wiesehahn, Annekatrin Schwanstecher, Marcus Hollenbach, Hendrik Luxenburger, Dominik Bettinger, Sophie Schlosser‐Hupf, for the JuGa study group   +24 more
wiley   +1 more source

THE IMPACT OF EVINACUMAB THERAPY ON PEDIATRIC PATIENTS WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA: RESULTS FROM PART B OF A PHASE 3 TRIAL

American Journal of Preventive Cardiology, 2023
Therapeutic Area: ASCVD /CVD Risk Reduction Background: Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disorder characterized by severely elevated low-density lipoprotein cholesterol (LDL-C) levels.
Albert Wiegman, Susanne Greber-Platzer, Shazia Ali, Divya Singh, M. Doortje Reijman, Eliot A Brinton, Min-Ji Charng, Shubha Srinivasan, Carissa Baker-Smith, Seth Baum, Julie Brothers, Jacob Hartz, Patrick M. Moriarty, Poulabi Banerjee, Richard T George, Robert Pordy   +15 more
doaj   +1 more source

Familial hypercholesterolemia: The Italian Atherosclerosis Society Network (LIPIGEN) [PDF]

, 2017
Primary dyslipidemias are a heterogeneous group of disorders characterized by abnormal levels of circulating lipoproteins. Among them, familial hypercholesterolemia is the most common lipid disorder that predisposes for premature cardiovascular disease ...
Angelico, F., Arca, M, Averna, M., Bertolini, S, Calandra, S, Casula, M, Catapano, Al, Cefalù, Ab, Del Ben, M., Lipigen, Group, Maranghi, M, Montali, A., Noto, D, Tarugi, P.   +13 more
core   +1 more source

Durability of Response to B‐Cell Maturation Antigen‐Directed mRNA Cell Therapy in Myasthenia Gravis

Annals of Clinical and Translational Neurology, Volume 12, Issue 11, Page 2358-2366, November 2025.
ABSTRACT Objective We report the 12‐month follow‐up outcomes from a Phase 2 clinical trial (NCT04146051) evaluating Descartes‐08, a BCMA‐directed RNA chimeric antigen receptor T‐cell (rCAR‐T) therapy for refractory generalized myasthenia gravis (MG).
Nizar Chahin, Gregory Sahagian, Marc H. Feinberg, C. Andrew Stewart, Christopher M. Jewell, Metin Kurtoglu, Miloš D. Miljković, Tuan Vu, Tahseen Mozaffar, James F. Howard Jr, the MG‐001 Study Group   +10 more
wiley   +1 more source

Influence of LDL apheresis on LDL subtypes in patients with coronary heart disease and severe hyperlipoproteinemia

Journal of Lipid Research, 2000
Epidemiologic studies and in vitro experiments indicate that low density lipoprotein (LDL) subtypes differ concerning their atherogenic potential. Small, dense LDL are more atherogenic than large, buoyant LDL.
B.M. Schamberger, H.C. Geiss, M.M. Ritter, P. Schwandt, K.G. Parhofer   +4 more
doaj   +1 more source

Pollens derived magnetic porous particles for adsorption of low-density lipoprotein from plasma

Bioactive Materials, 2021
Adsorption of low-density lipoprotein from plasma is vital for the treatment of dyslipidemia. Appropriate adsorbent material for efficient and selective adsorption of low-density lipoprotein is highly desired.
Yuetong Wang, Lingyu Sun, Jiahui Guo, Keqing Shi, Luoran Shang, Jian Xiao, Yuanjin Zhao   +6 more
doaj   +1 more source