Results 1 to 10 of about 38,551 (173)

Associations of intra-pancreatic fat deposition with triglyceride-rich lipoproteins and lipoprotein lipase. [PDF]

Diabetes Obes Metab
Abstract Aims To investigate the associations of intra‐pancreatic fat deposition (IPFD) with very‐low‐density lipoprotein (VLDL), intermediate‐density lipoprotein (IDL) and lipoprotein lipase. Materials and methods A total of 174 participants underwent magnetic resonance imaging on a 3.0 Tesla scanner for the quantification of IPFD.
Liu Y, Skudder-Hill L, Kimita W, Shamaitijiang X, Sequeira-Bisson IR, Petrov MS.   +5 more
europepmc   +2 more sources

Stabilizing lipoprotein lipase [PDF]

Journal of Lipid Research, 2009
Evidence from several prospective observational studies points toward the independent predictive value of plasma triglycerides in assessing cardiovascular risk (1). Hence, plasma triglycerides are increasingly targeted as a specific cardiovascular treatment outcome.
Kersten, A.H., Bensadoun, A.
openaire   +3 more sources

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Homology of lipoprotein lipase to pancreatic lipase. [PDF]

Proceedings of the National Academy of Sciences, 1986
Bovine milk lipoprotein lipase was subjected to amino acid sequence analysis. The first 19 amino-terminal residues were Asp-Arg-Ile-Thr-Gly-Gly-Lys-Asp-Phe-Arg-Asp-Ile-Glu-Ser-Lys-Phe-Ala-Leu- Arg. In addition, reversed-phase high-performance liquid chromatography of a tryptic digest of reduced and alkylated lipase resolved a number of peptides, five ...
Mary E. Pedersen, Michael C. Schotz, Chad Miller Ben-Avram, Kristen Haaga, Joseph R. Reeve, John Goers, Terry D. Lee, John E. Shively, Osnat Ben-Zeev   +8 more
openaire   +3 more sources

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

Lipoprotein lipase is active as a monomer [PDF]

Proceedings of the National Academy of Sciences, 2019
Significance Lipoprotein lipase (LPL) plays a central role in plasma lipid metabolism, hydrolyzing the triglycerides in lipoproteins and releasing fatty acid nutrients for vital tissues. LPL is synthesized by adipocytes and myocytes and secreted into the interstitial spaces, whereupon it is captured by an endothelial cell protein, GPIHBP1 ...
Stephen G. Young, Stephen G. Young, Muthuraman Meiyappan, Gabriel Birrane, Christopher M. Allan, Katsuyuki Nakajima, Patrick J Heizer, Kazuya Miyashita, Masami Murakami, Norma P. Sandoval, Anne P. Beigneux, Loren G. Fong, Michael Ploug, John E Gill, Peter J. Havel, Kimber L. Stanhope, Geoffrey W Cho, Rachel S. Jung   +17 more
openaire   +4 more sources

Lipoprotein lipase [PDF]

Journal of Lipid Research, 2002
Lipoprotein lipase (LPL) regulates the plasma levels of triglyceride and HDL. Three aspects are reviewed. 1) Clinical implications of human LPL gene variations: common mutations and their effects on plasma lipids and coronary heart disease are discussed.
Robert H. Eckel, Martin Merkel, Ira J. Goldberg   +2 more
openaire   +4 more sources

Gαq signalling from endosomes: A new conundrum

British Journal of Pharmacology, EarlyView., 2023
Abstract G‐protein‐coupled receptors (GPCRs) constitute the largest family of membrane receptors, and are involved in the transmission of a variety of extracellular stimuli such as hormones, neurotransmitters, light and odorants into intracellular responses.
Carole Daly, Bianca Plouffe
wiley   +1 more source

Lipoprotein lipase and obesity [PDF]

Health, 2012
Obesity is one of the fast-growing major diseases in developed and developing countries. As has been persuasively argued, long-term imbalance between intake and expenditure of fat is a central factor in the etiology of obesity. Obesity aggravates insulin resistance and promotes cardiovascular diseases and atherosclerosis.
Masataka Kusunoki, Takao Nakamura, Kazuhiko Tsutsumi, Daisuke Sato   +3 more
openaire   +2 more sources

Lipoprotein-lipase responses to heparin [PDF]

Journal of British Surgery, 1971
Abstract Recent evidence suggests an interrelationship between platelets, heparin, and the lipolytic enzyme, lipoprotein-lipase. It seems likely that heparin might influence platelet adherence through its activation of lipoprotein-lipase. The mode of activation of the enzyme by heparin may, therefore, be important clinically.
J. M. Ham, R. W. Furneaux, C. M. Morris, J. Kirumba   +3 more
openaire   +2 more sources