Results 61 to 70 of about 80,622 (214)

Associations Between Lipids and Lipid‐Lowering Drug Target Genes and Osteomyelitis: A Mendelian Randomization Analysis

Medicine Advances, EarlyView.
In this study, we identified several SNPs in PCSK9 as genetic tools to comprehensively assess the influential role of PCSK9 in CHD, CRP, and osteomyelitis. PCSK9 is associated with a lower risk of osteomyelitis, and PCSK9 is also associated with a reduction in CRP concentrations. Our study supports the notion that WC may be a potential mediator between
Zhiyi Zhou, Zhehan Yang, Junpan Chen, Minghao Wen, Jiayuan Lei, Wanzhe Liao, Yahan Li, Linghui Liu, Ziyuan Lu   +8 more
wiley   +1 more source

Obesity: A Biobehavioral Point of View

, 1990
Excerpt: If you ask an overweight person, “Why are you fat?’, you will, almost invariably, get the answer, “Because 1 eat too much.” You will get this answer in spite of the fact that of thirteen studies, six find no significant differences in the ...
Acheson K. J., Acheson K. J., Benedict F. G., Bennett W., Bjorntorp P., Borjeson M., Bray G. A., Bray G. A., Brook C. D. G., Brook C. G. D., Cleary M. P., DeLuise M., Despres J. P., DiGirolamo M., Festing M. F. W., Flatt J. P., Flatt J. P., Galton D. J., Garrow J. S., Gasquet P., Gruen R., Gruen R. K., Hensel H., Hogan S., Itallie T. B., Itallie T. B., Kern P. A., Landsberg L., Lin M. H., McMinn M. R., Morgan B. L. G., Newsholme E. A., Rath E. A., Rodin J., Rothwell N. J., Schurz Y., Schwartz R. S., Schwartz R. S.   +37 more
core   +1 more source

Resveratrol Prevents Weight Gain, Counteracts Visceral Adipose Tissue Dysfunction, and Improves Hypothalamic Leptin Sensitivity in Diet‐Induced Obese Rats

Molecular Nutrition &Food Research, EarlyView.
Resveratrol improves hypothalamic leptin sensitivity and prevents body weight gain in obese animals, while mitigating adipocyte hypertrophy and promoting adipocyte hyperplasia in the retroperitoneal fat depot. ABSTRACT In obesity, increased adipocyte size is associated with metabolic complications, while elevated adipocyte numbers are considered a ...
Maria Ibars‐Serra, Aïda Pascual‐Serrano, Andrea Ardid‐Ruiz, Núria Doladé, Sonia Aguilar‐González, Julieta Cirasino, Begoña Muguerza, Manuel Suárez, Jaap Keijer, Anna Arola‐Arnal, Gerard Aragonès   +10 more
wiley   +1 more source

Plasma lipoprotein subfraction concentrations are associated with lipid metabolism and age-related macular degeneration [PDF]

, 2017
10.1194/jlr.M073684Journal of Lipid Research5891785 ...
Apte, Rajendra S., Chee, Miao Ling, Cheng, Ching-Yu, Fan, Qiao, Gan, Alfred, Gemmy Cheung, Chui Ming, Khor, Chiea Chuen, Mathur, Ranjana, Tai, E. Shyong, Wong, Tien Yin, Yeo, Ian   +10 more
core   +2 more sources

Changes in Liver Metabolome Induced by Pterostilbene and Resveratrol in a Rat Model of Liver Steatosis

Molecular Nutrition &Food Research, EarlyView.
Resveratrol and pterostilbene reduced the steatotic status of animals fed a high‐fat, high‐sucrose diet, involving differential and specific mechanisms of action for each stilbene. Thus, changes in riboflavin metabolism, nicotinamide mononucleotide metabolism, or in the LysoPC(18:1)‐mediated effects contribute to the specific actions of pterostilbene ...
Alfredo Fernández‐Quintela, Emily P. Laveriano‐Santos, Tania Portolés, Andreu Gual‐Grau, Juan Vicente Sancho, Maria P. Portillo   +5 more
wiley   +1 more source

Mechanisms of Energy Balance in Obesity

, 1984
The proper understanding of obesity requires a multifaceted approach. Behavioral considerations of eating and activity patterns do not account for the large between- and within-subjects variance associated with the energy-balance equation.
McMinn, Mark R.
core  

Differential Effects of Wild Blueberry (Poly)Phenol Metabolites in Modulating Lipid Metabolism and Oxidative Stress in 3T3‐L1 Adipocytes

Molecular Nutrition &Food Research, EarlyView.
Metabolites derived from wild blueberry (poly)phenols, such as syringic (SA), vanillic (VA), and isoferulic acids (IA), can modulate lipid metabolism and oxidative stress markers in mature 3T3‐L1 adipocytes treated with free fatty acids (FFAs; oleic/palmitic acid, 750 µM, 2:1 ratio).
Samuele Venturi, Marco Rendine, Mirko Marino, Dorothy Klimis‐Zacas, Patrizia Riso, Cristian Del Bo'   +5 more
wiley   +1 more source

Photoperiod‐Dependent Effects of Phenolic‐Enriched Fruit Extracts on Postprandial Triacylglyceride Levels and Acute Inflammatory Responses in F344 Rats

Molecular Nutrition &Food Research, EarlyView.
This study investigates the photoperiod‐dependent effects of eight phenolic‐rich fruit extracts on postprandial blood triacylglyceride (TAG) levels and serum inflammatory markers in F344 rats, following an oral lipid tolerance test (OLTT) and a lipopolysaccharide (LPS)‐induced inflammatory challenge. Results showed that cherry and plum extracts reduced
Francesca Manocchio, Diego Morales, Èlia Navarro‐Masip, Gerard Aragones, Cristina Torres‐Fuentes, Francisca Isabel Bravo, Begoña Muguerza   +6 more
wiley   +1 more source

Population Pharmacokinetics and Exposure‐Response Modeling for Evinacumab in Children, Adolescents, and Adults With Homozygous Familial Hypercholesterolemia

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Evinacumab, an angiopoietin‐like 3 (ANGPTL3) inhibitor, significantly reduces low‐density lipoprotein cholesterol (LDL‐C), independent of low‐density lipoprotein receptor, in patients with homozygous familial hypercholesterolemia (HoFH). A population pharmacokinetic (PK)/pharmacodynamic (PD) model was previously developed to characterize ...
Sébastien Bihorel, Robert Dingman, Jeanne Mendell, Yuhuan Wang, Poulabi Banerjee, Robert Pordy, John D. Davis, A. Thomas DiCioccio, Lutz Harnisch   +8 more
wiley   +1 more source

Hepatitis C virus relies on lipoproteins for its life cycle [PDF]

, 2016
Hepatitis C virus (HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma.
Alonzi, Tonino, DI CAPRIO, Giorgia, Fimia, Gian Maria, Grassi, Germana, Ippolito, Giuseppe, Tripodi, Marco   +5 more
core   +1 more source