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Cellular signalling by lipoprotein receptors
Current Opinion in Lipidology, 2000 Lipoprotein receptors are commonly thought merely to mediate the internalization of lipoprotein particles or the exchange of lipids at the cell surface. Recent findings have now implicated these multifunctional receptors in cellular signalling mechanisms that extend beyond simple ligand endocytosis.
J, Herz, M, Gotthardt, T E, Willnow
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Lipoprotein Receptors in the Nervous System
Annual Review of Biochemistry, 2002 ▪ Abstract The low-density–lipoprotein (LDL) receptor family is an evolutionarily ancient gene family of structurally closely related cell-surface receptors. Members of the family are involved in the cellular uptake of extracellular ligands and regulate diverse biological processes including lipid and vitamin metabolism and cell-surface protease ...
Joachim, Herz, Hans H, Bock
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Lipoprotein receptors and atherosclerosis
Clinical Science, 1986Mammalian cholesterol metabolism is governed by two key features of the steroid nucleus: it is poorly soluble in plasma and it cannot be degraded in animal tissues. Cells which require the lipid import it through their cytoplasmic membranes in the form of solubilized lipid-protein complexes, and a similar export mechanism is essential in order to ...
J, Shepherd, C J, Packard
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Cellular and molecular biology (Noisy-le-Grand, France), 1994
Lipoprotein receptors are membrane proteins which play a central role in lipid metabolism. Although cells are capable of synthetizing de novo cholesterol from acetate, cholesterol is mostly of food origin or synthetized by the liver. The liver is the only organ which can catabolize the cholesterol and clear it from the circulation into biliary acids ...
W. J. S. de Villiers +2 more
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Lipoprotein receptors are membrane proteins which play a central role in lipid metabolism. Although cells are capable of synthetizing de novo cholesterol from acetate, cholesterol is mostly of food origin or synthetized by the liver. The liver is the only organ which can catabolize the cholesterol and clear it from the circulation into biliary acids ...
W. J. S. de Villiers +2 more
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Macrophage lipoprotein receptors
Journal of Cell Science, 1988ABSTRACT Macrophages possess a number of surface receptors that are capable of mediating the internalization of lipoproteins. The low-density lipoprotein (LDL) receptor of human monocyte macrophages recognizes apolipoprotein B-100 and apolipoprotein E and is rapidly regulated in response to changes in intracellular cholesterol levels. In
A M, Fogelman +4 more
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Lipoprotein receptors and cholesterol homeostasis
BBA - Biomembranes, 1983T L Innerarity +2 more
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Lipoprotein-receptor interactions
1986Publisher Summary This chapter focuses on the lipoprotein–receptor interactions. Lipoprotein receptors function as a major control mechanism for the regulation of lipoprotein catabolism. The classical studies of Goldstein and Brown demonstrated the importance of low-density lipoprotein (LDL) receptors in supplying cells with cholesterol and in ...
T L, Innerarity, R E, Pitas, R W, Mahley
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Hepatocytic lipoprotein receptors and intracellular lipoprotein catabolism
Hepatology, 1988Hepatocytes, as the major site of synthesis and terminal catabolism of plasma lipoproteins, exert the major regulatory influence on the concentration of atherogenic lipoproteins in blood plasma and may thereby influence the rate of atherogenesis. The LDL receptor on the microvillous sinusoidal surface of hepatocytes mediates the catabolism of remnants ...
R J, Havel, R L, Hamilton
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Lipoprotein receptors and atherosclerosis
Biochemical Society Transactions, 1989The whole lipoprotein spectrum of human plasma may be divided into atherosclerotic and anti-atherosclerotic lipoproteins. To the first class belong apolipoprotein (apo) B and some apoE-containing lipoproteins of the very-low-density (VLDL), intermediate-density (IDL) and low-density (LDL) lipoprotein fractions.
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The Lipoprotein Receptor Concept
Drugs, 1988The interaction of plasma lipoproteins with mammalian cells is facilitated by specific receptors on the cell surface. The chylomicron remnant receptor recognises apolipoprotein E (apo E) and mediates the uptake of chylomicron remnants by the liver. The low density lipoprotein (LDL) receptor recognises lipoproteins containing apolipoprotein B100 or an ...
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