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Lipoprotein and receptor interactions in vivo
Current Opinion in Lipidology, 1995A substantial number of animal models aimed at the genetic dissection of lipid metabolism have been generated recently. Transgenic and knockout mice, in which the receptors or apolipoproteins are overexpressed or destroyed, combined with virus-mediated gene transfer in vivo have advanced our understanding of the complex physiological and ...
J, Herz, T E, Willnow
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Lipoprotein receptors: therapeutic implications
Journal of Hypertension, 1990Knowledge of the transport pathways for cholesterol in blood helps us to understand the mechanisms underlying genetic and acquired forms of hypercholesterolaemia, and sets the stage for rational treatment with diet and drugs. A key element is a cell-surface receptor that binds cholesterol-rich lipoproteins of intermediate and low density.
M S, Brown, J L, Goldstein
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Lipoprotein receptors in the vascular wall
Current Opinion in Lipidology, 2004We will discuss the diverse roles of lipoprotein receptors that contribute to the maintenance and integrity of the vascular wall.Lipoprotein receptors function not only as transporters for cholesterol and other lipids. They also act as sensors and signal transducers through which the endothelium, macrophages and smooth muscle cells communicate with ...
Joachim, Herz, David Y, Hui
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Lipoprotein Receptors and Endothelial Cells
Seminars in Thrombosis and Hemostasis, 1988The interaction of lipoproteins with endothelial receptors can result in alterations in macromolecular transport, in changes in monocyte adherence to the endothelium, and in the production of monocyte chemotactic factor by the endothelium. Monocyte migration in response to such factors can further alter lipoprotein transport into the subendothelial ...
A M, Fogelman +4 more
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Lipoprotein receptors in oocyte growth
The Clinical Investigator, 1992The transport and removal of lipoproteins from the blood in the laying hen is of particular interest because it is a system in which the massive transport of lipid to one organ (the ovary) coexists with regulatory mechanisms for the control of lipid homeostasis in extraovarian tissues.
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Lipoprotein receptors and atherogenic receptor-mediated mechanisms
Current Opinion in Lipidology, 1994The liver plays a decisive role in the regulation of the plasma levels of atherogenic lipoproteins. The primary liver interaction site of chylomicron remnants and VLDL remnants (beta-VLDL) is still unidentified, whereas the subsequent cellular uptake is likely to be mediated in concert by the LDL receptor-related protein and the LDL receptor.
T J, van Berkel +3 more
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Receptor Interactions Controlling Lipoprotein Metabolism
Canadian Journal of Biochemistry and Cell Biology, 1984Lipoprotein receptors play a central role in lipoprotein metabolism and a major role in cholesterol homeostasis. The most completely characterized lipoprotein receptor is the LDL (low density lipoprotein) or apo-B,E(LDL) receptor. The apo-B,E(LDL) receptor is present on both hepatic and extrahepatic cells and is responsible for the metabolism of a ...
K H, Weisgraber +3 more
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The low density lipoprotein receptor
Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1989The study of familial hypercholesterolemia at the molecular level has led to its advancement from a clinical syndrome to a fascinating experimental system. FH was first described 50 years ago by Carl Müller who concluded that the disease produces high plasma cholesterol levels and myocardial infarctions in young people, and is transmitted as an ...
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Hypertriglyceridemia: Lipoprotein Receptors and Atherosclerosis
1985We have shown first, that apoB mediates the binding of small VLDL Sf 20-60 and IDL, as well as LDL, to the LDL receptor. Second, apoE of an appropriate, accessible conformation is required for the binding of large VLDL to the LDL receptor; HTG-VLDL Sf greater than 60 but not normal VLDL Sf greater than 60 have this apoE population.
S H, Gianturco, A M, Gotto, W A, Bradley
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Lipoprotein receptors in perspective
Current Opinion in Lipidology, 1992Recent findings regarding mutant founder genes, structure/function relationships and regulation of the LDL receptor are reviewed. New aspects regarding the control of the LDL receptor-related protein are presented. The structure and function of the scavenger receptor and the physiological role of the HDL receptor are considered.
Gerhard A. Coetzee +1 more
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