Results 241 to 250 of about 211,317 (295)
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Macrophage lipoprotein receptors
Journal of Cell Science, 1988ABSTRACT Macrophages possess a number of surface receptors that are capable of mediating the internalization of lipoproteins. The low-density lipoprotein (LDL) receptor of human monocyte macrophages recognizes apolipoprotein B-100 and apolipoprotein E and is rapidly regulated in response to changes in intracellular cholesterol levels. In
A M, Fogelman +4 more
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Lipoprotein-receptor interactions
1986Publisher Summary This chapter focuses on the lipoprotein–receptor interactions. Lipoprotein receptors function as a major control mechanism for the regulation of lipoprotein catabolism. The classical studies of Goldstein and Brown demonstrated the importance of low-density lipoprotein (LDL) receptors in supplying cells with cholesterol and in ...
T L, Innerarity, R E, Pitas, R W, Mahley
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Lipoprotein receptors and atherosclerosis
Clinical Science, 1986Mammalian cholesterol metabolism is governed by two key features of the steroid nucleus: it is poorly soluble in plasma and it cannot be degraded in animal tissues. Cells which require the lipid import it through their cytoplasmic membranes in the form of solubilized lipid-protein complexes, and a similar export mechanism is essential in order to ...
J, Shepherd, C J, Packard
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Lipoprotein receptors: therapeutic implications
Journal of Hypertension, 1990Knowledge of the transport pathways for cholesterol in blood helps us to understand the mechanisms underlying genetic and acquired forms of hypercholesterolaemia, and sets the stage for rational treatment with diet and drugs. A key element is a cell-surface receptor that binds cholesterol-rich lipoproteins of intermediate and low density.
M S, Brown, J L, Goldstein
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Hepatocytic lipoprotein receptors and intracellular lipoprotein catabolism
Hepatology, 1988Hepatocytes, as the major site of synthesis and terminal catabolism of plasma lipoproteins, exert the major regulatory influence on the concentration of atherogenic lipoproteins in blood plasma and may thereby influence the rate of atherogenesis. The LDL receptor on the microvillous sinusoidal surface of hepatocytes mediates the catabolism of remnants ...
R J, Havel, R L, Hamilton
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Receptor Interactions Controlling Lipoprotein Metabolism
Canadian Journal of Biochemistry and Cell Biology, 1984Lipoprotein receptors play a central role in lipoprotein metabolism and a major role in cholesterol homeostasis. The most completely characterized lipoprotein receptor is the LDL (low density lipoprotein) or apo-B,E(LDL) receptor. The apo-B,E(LDL) receptor is present on both hepatic and extrahepatic cells and is responsible for the metabolism of a ...
K H, Weisgraber +3 more
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Lipoprotein receptors and atherogenic receptor-mediated mechanisms
Current Opinion in Lipidology, 1994The liver plays a decisive role in the regulation of the plasma levels of atherogenic lipoproteins. The primary liver interaction site of chylomicron remnants and VLDL remnants (beta-VLDL) is still unidentified, whereas the subsequent cellular uptake is likely to be mediated in concert by the LDL receptor-related protein and the LDL receptor.
T J, van Berkel +3 more
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The Lipoprotein Receptor Concept
Drugs, 1988The interaction of plasma lipoproteins with mammalian cells is facilitated by specific receptors on the cell surface. The chylomicron remnant receptor recognises apolipoprotein E (apo E) and mediates the uptake of chylomicron remnants by the liver. The low density lipoprotein (LDL) receptor recognises lipoproteins containing apolipoprotein B100 or an ...
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Cellular signalling by lipoprotein receptors
Current Opinion in Lipidology, 2000Lipoprotein receptors are commonly thought merely to mediate the internalization of lipoprotein particles or the exchange of lipids at the cell surface. Recent findings have now implicated these multifunctional receptors in cellular signalling mechanisms that extend beyond simple ligand endocytosis.
J, Herz, M, Gotthardt, T E, Willnow
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Lipoprotein Receptors and Endothelial Cells
Seminars in Thrombosis and Hemostasis, 1988The interaction of lipoproteins with endothelial receptors can result in alterations in macromolecular transport, in changes in monocyte adherence to the endothelium, and in the production of monocyte chemotactic factor by the endothelium. Monocyte migration in response to such factors can further alter lipoprotein transport into the subendothelial ...
A M, Fogelman +4 more
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