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Cellular and molecular biology (Noisy-le-Grand, France), 1994
Lipoprotein receptors are membrane proteins which play a central role in lipid metabolism. Although cells are capable of synthetizing de novo cholesterol from acetate, cholesterol is mostly of food origin or synthetized by the liver. The liver is the only organ which can catabolize the cholesterol and clear it from the circulation into biliary acids ...
W. J. S. de Villiers +2 more
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Lipoprotein receptors are membrane proteins which play a central role in lipid metabolism. Although cells are capable of synthetizing de novo cholesterol from acetate, cholesterol is mostly of food origin or synthetized by the liver. The liver is the only organ which can catabolize the cholesterol and clear it from the circulation into biliary acids ...
W. J. S. de Villiers +2 more
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Macrophage lipoprotein receptors
Journal of Cell Science, 1988ABSTRACT Macrophages possess a number of surface receptors that are capable of mediating the internalization of lipoproteins. The low-density lipoprotein (LDL) receptor of human monocyte macrophages recognizes apolipoprotein B-100 and apolipoprotein E and is rapidly regulated in response to changes in intracellular cholesterol levels. In
A M, Fogelman +4 more
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Lipoprotein-receptor interactions
1986Publisher Summary This chapter focuses on the lipoprotein–receptor interactions. Lipoprotein receptors function as a major control mechanism for the regulation of lipoprotein catabolism. The classical studies of Goldstein and Brown demonstrated the importance of low-density lipoprotein (LDL) receptors in supplying cells with cholesterol and in ...
T L, Innerarity, R E, Pitas, R W, Mahley
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Lipoprotein receptors and atherosclerosis
Clinical Science, 1986Mammalian cholesterol metabolism is governed by two key features of the steroid nucleus: it is poorly soluble in plasma and it cannot be degraded in animal tissues. Cells which require the lipid import it through their cytoplasmic membranes in the form of solubilized lipid-protein complexes, and a similar export mechanism is essential in order to ...
J, Shepherd, C J, Packard
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Lipoprotein receptors: therapeutic implications
Journal of Hypertension, 1990Knowledge of the transport pathways for cholesterol in blood helps us to understand the mechanisms underlying genetic and acquired forms of hypercholesterolaemia, and sets the stage for rational treatment with diet and drugs. A key element is a cell-surface receptor that binds cholesterol-rich lipoproteins of intermediate and low density.
M S, Brown, J L, Goldstein
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Hepatocytic lipoprotein receptors and intracellular lipoprotein catabolism
Hepatology, 1988Hepatocytes, as the major site of synthesis and terminal catabolism of plasma lipoproteins, exert the major regulatory influence on the concentration of atherogenic lipoproteins in blood plasma and may thereby influence the rate of atherogenesis. The LDL receptor on the microvillous sinusoidal surface of hepatocytes mediates the catabolism of remnants ...
R J, Havel, R L, Hamilton
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Receptor Interactions Controlling Lipoprotein Metabolism
Canadian Journal of Biochemistry and Cell Biology, 1984Lipoprotein receptors play a central role in lipoprotein metabolism and a major role in cholesterol homeostasis. The most completely characterized lipoprotein receptor is the LDL (low density lipoprotein) or apo-B,E(LDL) receptor. The apo-B,E(LDL) receptor is present on both hepatic and extrahepatic cells and is responsible for the metabolism of a ...
K H, Weisgraber +3 more
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Lipoprotein receptors and atherogenic receptor-mediated mechanisms
Current Opinion in Lipidology, 1994The liver plays a decisive role in the regulation of the plasma levels of atherogenic lipoproteins. The primary liver interaction site of chylomicron remnants and VLDL remnants (beta-VLDL) is still unidentified, whereas the subsequent cellular uptake is likely to be mediated in concert by the LDL receptor-related protein and the LDL receptor.
T J, van Berkel +3 more
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