Results 271 to 280 of about 462,380 (329)

Efficacy and Safety of Tirzepatide in Japanese Participants With Obesity: A Subpopulation Analysis of the SURMOUNT‐1 Trial

Obesity, EarlyView.
ABSTRACT Objective This prespecified subpopulation analysis aimed to assess the efficacy and safety of once‐weekly tirzepatide versus placebo alongside lifestyle intervention in Japanese adults with obesity or overweight. Methods Data from 102 Japanese adults in the SURMOUNT‐1 trial with BMI ≥ 30 kg/m2 or ≥ 27 kg/m2 and ≥ 1 weight‐related comorbidity ...
Yasushi Ishigaki, Masamichi Yamada, Tomotaka Shingaki, Tomonori Oura, Iichiro Shimomura   +4 more
wiley   +1 more source

Influence of LDL cholesterol and Lp(a) on monocytes and macrophages in atherosclerosis. [PDF]

Biochem Med (Zagreb)
Ugovšek S, Jeras J, Šebeštjen M, Zupan J.   +3 more
europepmc   +1 more source

T‐Cell Signaling Pathways, Including Exhaustion, Predominate in Unhealthy Visceral and Subcutaneous Adipose Tissues

Obesity, EarlyView.
ABSTRACT Objective Obesity is an imperfect correlate of metabolic health. Visceral adipose tissue (VAT) characteristics are considered determinants of poor health and subcutaneous adipose tissue (SAT) considered protective. There is a gap in knowledge regarding shared vs.
Sobha Puppala, Alyssa R. Hamann, Christina M. Stevens, Alistaire Ruggiero, Laura A. Cox, Kylie Kavanagh   +5 more
wiley   +1 more source

2025 Egyptian guidelines for the management of dyslipidemia. [PDF]

Egypt Heart J
Reda A, Taha HS, Badran HM, Khamis H, Kamal S, Elserafy AS, Dawoud MH, Elamragy AA, Bendary A, Shaker MM.   +9 more
europepmc   +1 more source

C/EBPα is Essential for Gonadal but Not Inguinal White Adipose Tissue Formation in Mice

Obesity, EarlyView.
Human genetics has linked the gene CEBPA to waist to hip ratio and adipose distribution. We generated mice with AdipoQ‐Cre driven deletion of Cebpa and found these mice to have a specific reduction in gonadal white adipose tissue and myriad other metabolic phenotypes.
Krista Y. Hu, Yu‐Lin Ma, Esme A. Dodge, Olivia A. B. Maguire, Caio V. Matias, Ryan P. Barney, Hector S. Himede, Juliana Gomez Pardo, Miriam Cepeda, Scott M. Gordon, Robert C. Bauer   +10 more
wiley   +1 more source

Metabolomic biomarkers of psychotic conversion in ultra-high-risk subjects: a pilot study. [PDF]

Transl Psychiatry
Avella MT, Bertho G, Giraud N, Kébir O, Caradeuc C, Labad J, Papiol S, Schulze TG, Krebs MO, Chaumette B, Frajerman A.   +10 more
europepmc   +1 more source

Comprehensive Insights into Natural Bioactive Compounds: From Chemical Diversity and Mechanisms to Biotechnological Innovations and Applications

ChemistryOpen, EarlyView.
Natural products derived from plants, animals, fungi, bacteria, and minerals contain diverse bioactive classes such as alkaloids, flavonoids, terpenoids, saponins, tannins, and phenolics. These natural products work through different mechanisms, including ROS inhibition, NF‐κB suppression, and cytokine regulation, and exhibit wide applications across ...
Sajid Ali, Atif Ali Khan Khalil, Muhammad Saeed Akhtar, Adnan Amin, Wajid Zaman   +4 more
wiley   +1 more source

Apolipoproteins in Chronic Kidney Disease and Kidney Transplant: A Long Unfinished Story. [PDF]

Int J Mol Sci
Secondulfo C, Izzo C, Vecchione N, Minelli G, Russo D, Russo D, Barra R, Molinaro G, Apicella L, Iacuzzo C, Pisani A, Hamzeh S, Amicone M, Cirillo M, Bilancio G.   +14 more
europepmc   +1 more source

Computational Evaluation of Statin Analogs Targeting HMG‐CoA Reductase for Coronary Artery Disease Treatment

ChemistryOpen, EarlyView.
Molecular dynamics analysis of novel statin analogs shows that binding induces superior stabilization of HMG‐CoA reductase. As shown by the solvent‐accessible surface area profile, ligand‐induced rigidity offers a new, effective strategy for drug design. Cardiovascular diseases remain a leading cause of global mortality.
Yoshua B. Mtulo, Geradius Deogratias, James E. Mgaya, Andrew S. Paluch, Lucas Paul   +4 more
wiley   +1 more source

Profile and predictors of metabolic syndrome among young adults attending a Medical College in Quetta City, Pakistan. [PDF]

J Pharm Policy Pract
Saleem F, Shahzad F, Ishaque A, Haider S, Iqbal Q, Farooqui M, Bashaar M.   +6 more
europepmc   +1 more source