Results 11 to 20 of about 20,742 (150)

VLDL receptor gene therapy for reducing atherogenic lipoproteins

Molecular Metabolism, 2023
Over the past 40 years, there has been considerable research into the management and treatment of atherogenic lipid disorders. Although the majority of treatments and management strategies for cardiovascular disease (CVD) center around targeting low-density lipoprotein cholesterol (LDL-C), there is mounting evidence for the residual CVD risk attributed
Krauss, Ronald M, Lu, Jonathan T, Higgins, Joseph J, Clary, Cathryn M, Tabibiazar, Ray   +4 more
openaire   +4 more sources

Postprandial lipoprotein metabolism: VLDL vs chylomicrons [PDF]

Clinica Chimica Acta, 2011
Since Zilversmit first proposed postprandial lipemia as the most common risk of cardiovascular disease, chylomicrons (CM) and CM remnants have been thought to be the major lipoproteins which are increased in the postprandial hyperlipidemia. However, it has been shown over the last two decades that the major increase in the postprandial lipoproteins ...
Akira Tanaka, Akira Tanaka, Akihiro Inazu, Peter J. Havel, Mitsuyo Okazaki, Takeaki Nagamine, Junji Kobayashi, Yoshiharu Tokita, Masumi Ai, Masumi Ai, Takamitsu Nakano, Katsuyuki Nakajima, Hiroshi Mabuchi, Kimber L. Stanhope   +13 more
openaire   +3 more sources

Heparin binding triggers human VLDL remodeling by circulating lipoprotein lipase: Relevance to VLDL functionality in health and disease

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2022
Hydrolysis of VLDL triacylglycerol (TG) by lipoprotein lipase (LpL) is a major step in energy metabolism and VLDL-to-LDL maturation. Most functional LpL is anchored to the vascular endothelium, yet a small amount circulates on TG-rich lipoproteins. As circulating LpL has low catalytic activity, its role in VLDL remodeling is unclear. We use pre-heparin
Antonio Pérez, José Luis Sánchez-Quesada, Inka Miñambres, Olga Gursky, Shobini Jayaraman   +4 more
openaire   +5 more sources

Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo [PDF]

Journal of Lipid Research, 2008
Scavenger receptor class B type I (SR-BI) functions as an HDL receptor that promotes the selective uptake of cholesteryl esters (CEs). The physiological role of SR-BI in VLDL metabolism, however, is largely unknown. SR-BI deficiency resulted in elevated VLDL cholesterol levels, both on chow diet and upon challenge with high-cholesterol diets.
I. Sophie T. Bos, Theo J.C. Van Berkel, Ruud Out, Reeni B. Hildebrand, Miranda Van Eck, J. Kar Kruijt, Menno Hoekstra   +6 more
openaire   +4 more sources

Down-regulation of lipoprotein lipase and VLDL receptor in rats with focal glomerulosclerosis [PDF]

Kidney International, 2002
Patients and animals with nephrotic syndrome and those with chronic renal failure (CRF) often exhibit hypertriglyceridemia and impaired very low-density lipoprotein (VLDL) clearance. Imai rats that were originally derived from Sprague-Dawley rats develop spontaneous proteinuria, hyperlipidemia, progressive renal insufficiency and histologic changes of ...
Nosratola D. Vaziri, Nosratola D. Vaziri, Kaihui Liang, Kaihui Liang, Tadashi Sato   +4 more
openaire   +3 more sources

The Differential Effects of HDL Subpopulations on Lipoprotein Lipase (LPL)-Mediated VLDL Catabolism [PDF]

Biomedicines, 2021
High-density lipoprotein (HDL) subpopulations functional assessment is more relevant for HDL anti-atherogenic activity than cholesterol level. The aim of the study was to assess the impact of HDL-2 and HDL-3 on lipoprotein lipase (LPL)-mediated very-low-density lipoprotein (VLDL) catabolism related to hypertriglyceridemia development.
Ewa Wieczorek, Agnieszka Ćwiklińska, Agnieszka Kuchta, Barbara Kortas-Stempak, Anna Gliwińska, Maciej Jankowski   +5 more
openaire   +3 more sources

Characterization of a very-low-density lipoprotein (VLDL)-associated cytotoxic factor [PDF]

British Journal of Cancer, 1981
A VLDL-associated cytotoxic factor was isolated from sera of pregnant rats and characterized. The inhibitory effect of this factor on the macromolecular synthesis of rat prostate adenocarcinoma cells (PA-III) was also examined. VLDL (Sf 20-400) was subfractionated by differential ultracentrifugal flotation and the Sf 100-400 fraction was associated ...
M. Pollard, S. Y. Chan
openaire   +3 more sources

ApoAV Reduces Plasma Triglycerides by Inhibiting Very Low Density Lipoprotein-Triglyceride (VLDL-TG) Production and Stimulating Lipoprotein Lipase-mediated VLDL-TG Hydrolysis [PDF]

Journal of Biological Chemistry, 2004
ApoAV has been discovered recently as a novel modifier of triglyceride (TG) metabolism, but the pathways involved are currently unknown. To gain insight into the function of apoAV, adenovirus-mediated gene transfer of murine apoa5 to C57Bl/6 mice was employed.
Albert K. Groen, Louis M. Havekes, Frank G. Schaap, Ko Willems van Dijk, Robert A. F. M. Chamuleau, Hendrik N. van der Vliet, Peter J. Voshol, Carlos L. J. Vrins, Patrick C.N. Rensen   +8 more
openaire   +3 more sources

Disrupted VLDL Features and Lipoprotein Metabolism in Sepsis [PDF]

, 2012
Gram-negative sepsis is an increasingly clinical syndrome triggered by exposure to bacterial lipopolysaccharide (LPS) or endotoxin. It is associated with a plethora of physiological and biochemical changes, known as acute-phase response (APR), including disturbances in serum lipid and lipoprotein levels (Khovidhunkit et al., 2004).
Patricia Aspichueta, Nerea Bartolomé, Xabier Buqué, Yolanda Chico, Begoña Ochoa, María José Martínez   +5 more
openaire   +3 more sources

Emerging Evidence of Pathological Roles of Very-Low-Density Lipoprotein (VLDL)

International Journal of Molecular Sciences, 2022
Embraced with apolipoproteins (Apo) B and Apo E, triglyceride-enriched very-low-density lipoprotein (VLDL) is secreted by the liver into circulation, mainly during post-meal hours. Here, we present a brief review of the physiological role of VLDL and a systemic review of the emerging evidence supporting its pathological roles.
Jih-Kai Huang, Hsiang-Chun Lee
openaire   +2 more sources