Results 11 to 20 of about 285,687 (237)

Triglyceride Rich Lipoprotein -LPL-VLDL Receptor and Lp(a)-VLDL Receptor Pathways for Macrophage Foam Cell Formation

Journal of Atherosclerosis and Thrombosis, 2017
Very low-density lipoprotein (VLDL) receptor is a member of the low-density lipoprotein (LDL) receptor family. It binds triglyceride rich lipoprotein (TGRL) but not LDL, because it recognizes apolipoprotein (apo)E only but not apoB. The VLDL receptor functions as a peripheral lipoprotein receptor in concert with lipoprotein lipase (LPL) in heart ...
Sadao Takahashi
openaire   +5 more sources

The Very Low-density Lipoprotein (VLDL) Receptor: Characterization and Functions as a Peripheral Lipoprotein Receptor

Journal of Atherosclerosis and Thrombosis, 2004
The very low-density lipoprotein (VLDL) receptor is a member of the low-density lipoprotein (LDL) receptor family. In vitro and in vivo studies have shown that VLDL receptor binds triglyceride (TG)-rich lipoproteins but not LDL, and functions as a peripheral remnant lipoprotein receptor.
Tokuo T. Yamamoto, Jinya Suzuki, Yasuo Zenimaru, Takahiro Fujino, Takahiro Fujino, Hiroaki Hattori, Isamu Miyamori, Juro Sakai, Sadao Takahashi   +8 more
openaire   +5 more sources

Adrenal Cell Aldosterone Production Is Stimulated by Very-Low-Density Lipoprotein (VLDL) [PDF]

Endocrinology, 2012
Very low-density lipoproteins (VLDL) are a class of large lipoprotein synthesized in the liver. The key function of VLDL, in vivo, is to carry triglyceride from the liver to adipose tissue. As a steroidogenic organ, the adrenal gland mainly uses lipoproteins as sources of cholesterol. Although VLDL receptors have been detected in the human adrenal, the
Wendy B. Bollag, Wendy B. Bollag, William E. Rainey, Yewei Xing, John W. Apolzan, Ruth B. S. Harris, Omar L. Francone   +6 more
openaire   +4 more sources

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

Remnants of the Triglyceride-Rich Lipoproteins, Diabetes, and Cardiovascular Disease

Diabetes, 2020
Diabetes is now a pandemic disease. Moreover, a large number of people with prediabetes are at risk for developing frank diabetes worldwide. Both type 1 and type 2 diabetes increase the risk of atherosclerotic cardiovascular disease (CVD).
A. Chait, H. Ginsberg, T. Vaisar, J. Heinecke, I. Goldberg, K. Bornfeldt   +5 more
semanticscholar   +1 more source

Short-term effects of exercise on plasma very low density lipoproteins (VLDL) and fatty acids.

Medicine & Science in Sports & Exercise, 1999
PURPOSE In the fasted state the lipid fuels for muscle metabolism are free fatty acids (FFA) released either from intramuscular triglycerides (TG), plasma albumin, or TG in circulating very low density lipoproteins (VLDL). The purposes of this study were
E. Børsheim, S. Knardahl, A. Høstmark
semanticscholar   +1 more source

Interaction of very low density lipoproteins (VLDL) with rabbit C-reactive protein.

Journal of Immunology, 1982
Rabbit CRP is similar to human CRP in structure, kinetics of appearance, and binding reactivities to phosphate esters and cationic polymers. CRP in rabbit acute-phase serum migrates either with gamma or with beta, pre-beta electrophoretic mobility, and ...
V. Cabana, H. Gewurz, J. Siegel
semanticscholar   +1 more source

Emerging Evidence of Pathological Roles of Very-Low-Density Lipoprotein (VLDL)

International Journal of Molecular Sciences, 2022
Embraced with apolipoproteins (Apo) B and Apo E, triglyceride-enriched very-low-density lipoprotein (VLDL) is secreted by the liver into circulation, mainly during post-meal hours. Here, we present a brief review of the physiological role of VLDL and a systemic review of the emerging evidence supporting its pathological roles.
Jih-Kai Huang, Hsiang-Chun Lee
openaire   +2 more sources

Ex VivoMeasurement of Lipoprotein Lipase-Dependent Very Low Density Lipoprotein (VLDL)-Triglyceride Hydrolysis in Human VLDL: An Alternative to the Postheparin Assay of Lipoprotein Lipase Activity?¹ [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2001
The plasma lipolysis of triglyceride (TG)-rich lipoproteins is mainly due to the activity of lipoprotein lipase (LPL). Albeit important for our analysis of certain physiopathological situations, the determination of the magnitude of LPL-dependent lipolysis is not easy to perform.
Bruno Vergès, Gabriel Ponsin, Francois Berthezene, Laurence Duvillard, Delphine Autran, Christophe Marçais, Philippe Moulin, Valerie Pruneta   +7 more
openaire   +3 more sources