Results 31 to 40 of about 284,504 (254)

Proteomic Analysis of the Very Low Density Lipoprotein (VLDL) transport vesicles [PDF]

Journal of Proteomics, 2012
The VLDL transport vesicle (VTV) mediates the transport of nascent VLDL particles from the ER to the Golgi and plays a key role in VLDL-secretion from the liver. The functionality of VTV is controlled by specific proteins; however, full characterization and proteomic profiling of VTV remain to be carried out. Here, we report the first proteomic profile
Riyaz Basha, Abdul Rahim, Shaila Siddiqi, Erika Nafi-valencia, Chukwuemeka C. Runyon, Shadab A. Siddiqi   +5 more
openaire   +4 more sources

Causes and Consequences of Hypertriglyceridemia

Frontiers in Endocrinology, 2020
Elevations in plasma triglyceride are the result of overproduction and impaired clearance of triglyceride-rich lipoproteins—very low-density lipoproteins (VLDL) and chylomicrons. Hypertriglyceridemia is characterized by an accumulation in the circulation
Chris J. Packard, Jan Boren, Marja-Riitta Taskinen   +2 more
doaj   +1 more source

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease.

Journal of Clinical Investigation, 2005
Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of excess liver triacylglycerol (TAG), inflammation, and liver damage.
Kerry L Donnelly, Coleman I. Smith, S. Schwarzenberg, J. Jessurun, M. Boldt, E. Parks   +5 more
semanticscholar   +1 more source

Ex VivoMeasurement of Lipoprotein Lipase-Dependent Very Low Density Lipoprotein (VLDL)-Triglyceride Hydrolysis in Human VLDL: An Alternative to the Postheparin Assay of Lipoprotein Lipase Activity?¹ [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2001
The plasma lipolysis of triglyceride (TG)-rich lipoproteins is mainly due to the activity of lipoprotein lipase (LPL). Albeit important for our analysis of certain physiopathological situations, the determination of the magnitude of LPL-dependent lipolysis is not easy to perform.
Bruno Vergès, Gabriel Ponsin, Francois Berthezene, Laurence Duvillard, Delphine Autran, Christophe Marçais, Philippe Moulin, Valerie Pruneta   +7 more
openaire   +3 more sources

Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion1[S]

Journal of Lipid Research, 2015
Humans and mice lacking angiopoietin-like protein 3 (ANGPTL3) have pan-hypolipidemia. ANGPTL3 inhibits two intravascular lipases, LPL and endothelial lipase, and the low plasma TG and HDL-cholesterol levels in ANGPTL3 deficiency reflect increased ...
Yan Wang, V. Gusarova, S. Banfi, J. Gromada, Jonathan C. Cohen, H. Hobbs   +5 more
semanticscholar   +1 more source

Inactivation of Tm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins*

Journal of Biological Chemistry, 2016
A missense mutation (E167K) in TM6SF2 (transmembrane 6 superfamily member 2), a polytopic protein of unknown function, is associated with the full spectrum of fatty liver disease. To investigate the role of TM6SF2 in hepatic triglyceride (TG) metabolism,
E. Smagris, S. Gilyard, Soumik Basuray, Jonathan C. Cohen, H. Hobbs   +4 more
semanticscholar   +1 more source

Phospholipids in lipoproteins: compositional differences across VLDL, LDL, and HDL in pregnant women [PDF]

Lipids in Health and Disease, 2019
The aim of this study was to analyse the differences in the phospholipid composition of very low density (VLDL), low density (LDL) and high density lipoprotein (HDL) monolayers in pregnant lean and obese women.LDL, HDL, and VLDL were isolated from plasma samples of 10 lean and 10 obese pregnant women, and their species composition of ...
Olaf Uhl, José E. Blanco-Carnero, María T. Prieto-Sánchez, Franca F. Kirchberg, Hans Demmelmair, Elvira Larqué, Aníbal Nieto, Antonio Gázquez, Antonio Gázquez, Berthold Koletzko, María Ruiz-Palacios, Sebastian Rauschert   +11 more
openaire   +5 more sources

Apolipoprotein B48 metabolism in chylomicrons and very low‐density lipoproteins and its role in triglyceride transport in normo‐ and hypertriglyceridemic human subjects

Journal of Internal Medicine, 2019
Renewed interest in triglyceride‐rich lipoproteins as causative agents in cardiovascular disease mandates further exploration of the integrated metabolism of chylomicrons and very low‐density lipoproteins (VLDL).
Elias Björnson, C. Packard, M. Adiels, L. Andersson, N. Matikainen, Sanni Söderlund, J. Kahri, A. Hakkarainen, N. Lundbom, J. Lundbom, C. Sihlbom, A. Thorsell, Haihong Zhou, M. Taskinen, J. Borén   +14 more
semanticscholar   +1 more source

Metabolism and Modification of Apolipoprotein B-Containing Lipoproteins Involved in Dyslipidemia and Atherosclerosis.

Biological and Pharmaceutical Bulletin, 2016
Increased levels of apolipoprotein B (apoB)-containing lipoproteins, such as low density lipoproteins (LDL) and chylomicron remnants, are associated with the development of atherosclerosis.
Shin-ya Morita
semanticscholar   +1 more source

Deficiency of the Very Low-Density Lipoprotein (VLDL) Receptors in Streptozotocin-Induced Diabetic Rats: Insulin Dependency of the VLDL Receptor [PDF]

Endocrinology, 2005
AbstractHyperlipidemia is a common feature of diabetes and is related to cardiovascular disease. The very low-density lipoprotein receptor (VLDL-R) is a member of the low-density lipoprotein receptor (LDL-R) family. It binds and internalizes triglyceride-rich lipoproteins with high specificity.
Masao Takahashi, Makoto Nagano, Hironobu Naiki, Norman E. Miller, Hiroaki Hattori, Takahiro Fujino, Tokuo T. Yamamoto, Sadao Takahashi, Takeshi Kujiraoka, Juro Sakai, Mitsuaki Ishihara, Yasuo Zenimaru, Jinya Suzuki, Tadao Iwasaki, Isamu Miyamori   +14 more
openaire   +3 more sources