Results 121 to 130 of about 145,969 (308)

Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin‐Mediated NRF2 Degradation

Advanced Science, EarlyView.
Lipid metabolic stress triggers ferroptosis in PDLSCs through the GSK3β/NRF2 pathway, thereby aggravating periodontal bone loss. Upregulated GSK3β promotes NRF2 ubiquitination and proteasomal degradation via β‐TrCP, suppressing NRF2 nuclear translocation and antioxidant target expression.
Yuxiao Zhang, Xiangyao Wang, Yaxin Wu, Liping Liu, Gaoshaer Nuerlan, Ahsawle Ozathaley, Xiaorui Zhang, Jinping Wang, Bowen Yang, Jing Mao, Yan Liu, Shiqiang Gong   +11 more
wiley   +1 more source

Antibodies to low-density lipoproteins modified by malonic dialdehyde: contents in blood and role in atherogenesis

Медицинская иммунология
In this work, we determined the content of antibodies to low-density lipoproteins modified by malondialdehyde, the concentration of circulating immune complexes cholesterol and oxidized low-density lipoproteins in the blood of healthy individuals and ...
A. A. Ivanova, A. A. Dmitrieva, A. D. Denisenko   +2 more
doaj   +1 more source

Studies of atherogenic lipoproteins using mass spectrometry-based lipidomics

, 2010
The prevalence of type 2 diabetes is increasing worldwide and is about to reach epidemic proportions. The disease is often associated with dyslipidemia which is characterized by an atherogenic lipoprotein profile including elevated serum triacylglycerol ...
Ståhlman, Marcus
core  

Lipoprotein(a) [PDF]

Clinical Research in Cardiology Supplements, 2019
K P, Mellwig, A, Vogt
openaire   +2 more sources

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source

Intestinal Source Control of Lipid Metabolism by Enzyme‐Probiotic Encapsulated, Spatiotemporal Crosslinked, and Small Intestine‐Adhesive Hydrogel Microspheres

Advanced Science, EarlyView.
A thiol‐modified alginate hydrogel microsphere‐encapsulated enzyme‐probiotic biohybrid (AKK‐COD) system has been developed to address the spatiotemporal delivery and colonization challenges of small intestine‐targeted probiotic for lipid metabolism regulation. The system exerts sequential functions of intragastric protection, small intestinal adhesion,
Xiaolin Wu, Weiwen Liang, Siqi He, Guangyuan Chen, Hui Zhou, Xinglong Wang, Yifei Li, Dingcai Wu, Bingna Zheng, Ruoxu Dou, Rongkang Huang   +10 more
wiley   +1 more source

Effects of n-3 fatty acids on the NMR profile of plasma lipoproteins

, 1996
The effects of fish oil supplementation (14.5 g n-3 fatty acids/day) on plasma lipoprotein particles in healthy volunteers were assessed by high resolution 13C and 1H nuclear magnetic resonance (NMR) spectroscopy.
Cunnane, S.C., Barnard, M.L., Thomas, E.L., Dagnelie, P.C., Bell, J.D., Brennan, C.H., Parkes, H.G.   +6 more
core  

Cholesterolemic Rabbit Lipoproteins: Serum Lipoproteins of the Cholesterolemic Rabbit

, 1955
The chemical composition of the low density lipoproteins (Sf 0 to 25. Sf 15 to 100, and Sf 20 to 400) has been investigated by isolating the molecules centrifugally and separating the various lipid constituents on silicic acid columns and analyzing the ...
Verne Norman Schumaker
core   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

Effect of lipoproteins on mesangial cell proliferation

, 1999
Effect of lipoproteins on mesangial cell proliferationBackgroundTriglyceride (TG)-rich lipoproteins have been reported to promote atherosclerosis, but little is known about their role in kidney disease or about their effects on mesangial cells ...
Yorioka, Noriaki, Oda, Hiroaki, Nishida, Yoji   +2 more
core   +1 more source