Results 11 to 20 of about 420,006 (308)

Lipoprotein(a) [PDF]

MMW - Fortschritte der Medizin, 2021
AbstractLipoprotein(a) [Lp(a)] is an atherogenic lipoprotein with a strong genetic regulation. Up to 90% of the concentrations are explained by a single gene, theLPAgene. The concentrations show a several-hundred-fold interindividual variability ranging from less than 0.1 mg/dL to more than 300 mg/dL. Lp(a) plasma concentrations above 30 mg/dL and even
openaire   +4 more sources

Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies—a consensus statement from the European Atherosclerosis Society

European Heart Journal, 2021
Recent advances in human genetics, together with a large body of epidemiologic, preclinical, and clinical trial results, provide strong support for a causal association between triglycerides (TG), TG-rich lipoproteins (TRL), and TRL remnants, and ...
H. Ginsberg, C. Packard, M. Chapman, J. Borén, C. Aguilar-Salinas, M. Averna, B. Ference, D. Gaudet, R. Hegele, S. Kersten, G. Lewis, A. Lichtenstein, P. Moulin, B. Nordestgaard, A. Remaley, B. Staels, E. Stroes, M. Taskinen, L. Tokgözoğlu, A. Tybjaerg-hansen, Jane K. Stock, A. Catapano   +21 more
semanticscholar   +1 more source

Structural and Functional Impairments of Reconstituted High-Density Lipoprotein by Incorporation of Recombinant β-Amyloid42

Molecules, 2021
Beta (β)-amyloid (Aβ) is a causative protein of Alzheimer’s disease (AD). In the pathogenesis of AD, the apolipoprotein (apo) A-I and high-density lipoprotein (HDL) metabolism is essential for the clearance of Aβ.
Kyung-Hyun Cho
doaj   +1 more source

Importance of Apolipoprotein A-I and A-II Composition in HDL and Its Potential for Studying COVID-19 and SARS-CoV-2

Medicines, 2021
The composition and properties of apolipoprotein (apo) A-I and apoA-II in high-density lipoproteins (HDL) might be critical to SARS-CoV-2 infection via SR-BI and antiviral activity against COVID-19.
Kyung-Hyun Cho
doaj   +1 more source

Rapid Decrease in HDL-C in the Puberty Period of Boys Associated with an Elevation of Blood Pressure and Dyslipidemia in Korean Teenagers: An Explanation of Why and When Men Have Lower HDL-C Levels Than Women

Medical Sciences, 2021
Low serum high-density lipoproteins-cholesterol (HDL-C) levels and high blood pressure are linked to each other and are recognized as independent risk factors of cardiovascular disease and dementia. HDL can cross the blood–brain barrier to remove amyloid
Kyung-Hyun Cho, Jae-Ryong Kim
doaj   +1 more source

Relationship between lipoproteins, thrombosis, and atrial fibrillation

Cardiovascular Research, 2021
The prothrombotic state in atrial fibrillation (AF) occurs as a result of multifaceted interactions, known as Virchow’s triad of hypercoagulability, structural abnormalities, and blood stasis.
W. Ding, M. Protty, I. Davies, G. Lip
semanticscholar   +1 more source

Lipoprotein (a): Recent Updates on a Unique Lipoprotein [PDF]

Current Atherosclerosis Reports, 2021
Genetic, epidemiological, and translational data indicate that Lipoprotein (a) [Lp(a)] is likely in the causal pathway for atherosclerotic cardiovascular diseases as well as calcification of the aortic valves.Lp(a) is structurally similar to low-density lipoprotein, but in addition to apolipoprotein B-100, it has a glycoprotein apolipoprotein(a) [apo(a)
Anum Saeed, Sina Kinoush, Salim S. Virani   +2 more
openaire   +2 more sources

Lipoproteins and lipids in cardiovascular disease: from mechanistic insights to therapeutic targeting.

Advanced Drug Delivery Reviews, 2020
With cardiovascular disease being the leading cause of morbidity and mortality worldwide, effective and cost-efficient therapies to reduce cardiovascular risk are highly needed.
Josefin Soppert, M. Lehrke, N. Marx, J. Jankowski, H. Noels   +4 more
semanticscholar   +1 more source

Lipoproteins and Atherosclerosis [PDF]

Journal of Gerontology, 1951
Author(s): Gofman, John W.; Lindgren, Frank T.; Jones, Hardin B.; Lyon, Thomas P.; Strisower, Beverly.
Gofman, John W., Lindgren, Frank T., Jones, Hardin B., Lyon, Thomas P., Strisower, Beverly.   +4 more
openaire   +3 more sources

Immunochemical characterization of six monoclonal antibodies to human apolipoprotein A-I: epitope mapping and expression.

Journal of Lipid Research, 1990
We have produced and characterized six murine monoclonal antibodies to human apolipoprotein A-I named A-I-9, A-I-12, A-I-15, A-I-16, A-I-19, and A-I-57. All monoclonal antibodies were specific for apolipoprotein A-I and bound between 55% and 100% of 125I-
S Marcovina, S Fantappie, A Zoppo, G Franceschini, AL Catapano   +4 more
doaj   +1 more source