Results 181 to 190 of about 114,873 (244)

Bupivacaine Binding to Pegylated Liposomes

Anesthesia & Analgesia, 2009
Local anesthetic drugs, such as bupivacaine, can cause severe toxicity. Lipid emulsions have been proposed and used clinically for treating such cases. Liposomes may be an alternative for overdose treatment because of their unique structures and surface charges, which allows them to act as high affinity drug "sinks" and remove bupivacaine from solution.
Brett A, Howell, Anuj, Chauhan
openaire   +2 more sources

Liposomal bupivacaine for regional anesthesia

Current Opinion in Anaesthesiology, 2015
Using a regional block in a multimodal approach to postoperative analgesia management involves addressing, which local anesthetic and how much should be used to ensure adequate pain relief to reduce related morbidity and mortality. This article will review literature surrounding the recently approved formulation of slow release liposomal bupivacaine ...
Anna, Uskova, Jessica E, O'Connor
openaire   +2 more sources

The Use of Liposomal Bupivacaine for Pain Control After Shoulder Surgery: A Systematic Review and Meta-analysis

American Journal of Sports Medicine
Background: Liposomal bupivacaine (LB) is a relatively novel anesthetic agent used in the management of postoperative pain in patients who have undergone shoulder surgery.
M. Fares, M. Daher, P. Boufadel, Adam Z. Khan, Joseph A. Abboud   +4 more
semanticscholar   +1 more source

Characterization of exparel bupivacaine multivesicular liposomes

International Journal of Pharmaceutics, 2023
Exparel is a bupivacaine multivesicular liposomes (MVLs) formulation developed based on the DepoFoam technology. The complex composition and the unique structure of MVLs pose challenges to the development and assessment of generic versions. In the present work, we developed a panel of analytical methods to characterize Exparel with respect to particle ...
Minzhi Yu, Wenmin Yuan, Ziyun Xia, Yayuan Liu, Yan Wang, Xiaoming Xu, Jiwen Zheng, Anna Schwendeman   +7 more
openaire   +2 more sources

Liposomal Bupivacaine, Plain Bupivacaine, and Saline for Transversus Abdominis Plane Blocks: The CLEVELAND Randomized Trial.

Anesthesiology
BACKGROUND Enhanced Recovery After Surgery (ERAS) pathways recommend transversus abdominis plane (TAP) blocks, but their efficacy is controversial and limited by the duration of local anesthetics.
A. Turan, W. A. Esa, Jack E. Brooker, Michael Rosen, E. Ekrami, B. T. Cekmecelioglu, Harsha Nair, Ahmad Al Jarkas, Karan Shah, C. Mueller, Michael A. Valente, Nour A. El Hage Chehade, D. I. Sessler   +12 more
semanticscholar   +1 more source

Ultrasound-guided paravertebral block with liposomal bupivacaine vs. non-liposomal bupivacaine for postoperative pain control after the Nuss procedure in children: A randomized clinical trial.

Journal of clinical anesthesia
STUDY OBJECTIVE Minimally invasive repair of pectus excavatum (Nuss procedure) is associated with significant postoperative pain and high-dose opioid consumption.
Lei Wu, Si-Wei Wei, Zheng Chen, Li-Dan Jiang, Shuang-Quan Qu, Zhen Du   +5 more
semanticscholar   +1 more source

Effect of Liposomal Bupivacaine for Preoperative Thoracic Paravertebral Blockade on Postoperative Pain Following Video-Assisted Thoracoscopic Lung Surgery: A Prospective, Double-Blind, Randomized Controlled Trial.

Journal of Cardiothoracic and Vascular Anesthesia
OBJECTIVES To compare liposomal bupivacaine versus ropivacaine for acute and chronic pain management via preoperative thoracic paravertebral blockade (TPVB) in thoracoscopic lung resection.
Yingying Wei, Xiaochun Wei, Fang He, Guo-Feng Liu, Li-Fang Zhou, Yizhi Lu, Yubo Xie, Yanhua Chen   +7 more
semanticscholar   +1 more source

Analgesic Effectiveness of Liposomal Bupivacaine versus Plain Local Anesthetics for Abdominal Fascial Plane Blocks: A Systematic Review and Meta-analysis of Randomized Trials

Anesthesiology
Background: Liposomal bupivacaine is reported to prolong the duration of analgesia when used for abdominal fascial plane blocks compared to plain local anesthetics; however, evidence from randomized trials is mixed. This meta-analysis aims to compare the
N. Hussain, Jarod Speer, F. Abdallah
semanticscholar   +1 more source

Efficacy of thoracic paravertebral block with liposomal bupivacaine for postoperative analgesia in patients undergoing liver resection: A randomized controlled trial.

Journal of clinical anesthesia
BACKGROUND Patients often suffer from moderate to severe acute postoperative pain after liver resection, and the use of liposomal bupivacaine (LB) for pain management is widespread.
Jiang-Ling Wang, Daoying Zhou, Sunyuan Xu, Z. Ding, Man Fang, Ping Chen, Ping-Bo Xu   +6 more
semanticscholar   +1 more source

Liposomal bupivacaine: examining the factors behind inconsistent analgesic results

Regional anesthesia and pain medicine
Liposomal bupivacaine (LB) has been the subject of a great deal of study, and some degree of controversy, since its development in the late 1990s. While some published studies are supportive of its efficacy, many others are not or demonstrate only ...
Steven L. Orebaugh, Mariusz Ligocki, Henry Guo, Hong Chen   +3 more
semanticscholar   +1 more source