Results 91 to 100 of about 83,144 (307)

Liposome-based carrier systems and devices used for pulmonary drug delivery

, 2017
Liposomes are spherical lipid carrier vesicles that vary in size (typically in the range of 20. nm to 20. μm), and are composed of single or multi-concentric bilayers, and have the ability to entrap both hydrophilic therapeutic agents within their ...
Waqar Ahmed (17152585), Iftikhar Khan (9694055), Mohamed Albed Alhnan (3397838), Mahmood Shah (16659672), Abdelbary Elhissi (3397829)   +4 more
core   +1 more source

The Preparation, Determination of a Flexible Complex Liposome Co-Loaded with Cabazitaxel and β-Elemene, and Animal Pharmacodynamics on Paclitaxel-Resistant Lung Adenocarcinoma

Molecules, 2019
Paclitaxel is highly effective at killing many malignant tumors; however, the development of drug resistance is common in clinical applications. The issue of overcoming paclitaxel resistance is a difficult challenge at present.
Yi-Ying Zeng, Yi-Jun Zeng, Na-Na Zhang, Chen-Xi Li, Tian Xie, Zhao-Wu Zeng   +5 more
doaj   +1 more source

Unravelling the role of lipid composition on liposome-protein interactions

, 2023
Upon in vivo administration of nanoparticles, a protein corona forms on their surface and affects their half-life in circulation, biodistribution properties, and stability; in turn, the composition of the protein corona depends on the physico-chemical ...
Biondi, Marco, Giancola, Concetta, Marco Biondi, Giuseppe De Rosa, Campani, Virginia, Virginia Campani, Concetta Giancola, Silvestri, Teresa, Federica D’Aria, D'Aria, Federica, Valeria Nele, Teresa Silvestri, De Rosa, Giuseppe, Nele, Valeria   +13 more
core   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

MAGfect: a novel liposome formulation for MRI labelling and visualization of cells

, 2006
Cellular entry of imaging probes, such as contrast agents for magnetic resonance imaging (MRI), is a key requirement for many molecular imaging studies, particularly imaging intracellular events and cell tracking.
Oliver, M.H., Keller, M., Caussin, A., Ahmad, A., Jorgensen, M.R., Perouzel, E., Kamaly, N., Bell, J.D., Herlihy, A.H., Miller, A.D.   +9 more
core   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Liposome-Enhanced Polymerization-Based Signal Amplification for Highly Sensitive Naked-Eye Biodetection in Paper-Based Sensors

, 2019
Polymerization-based signal amplification (PBA) is a material-based approach to improving the sensitivity of paper-based diagnostic tests. Eosin Y is used as an assay label to photo-initiate free-radical polymerization to produce colored hydrogels in the
Seunghyeon Kim (701965), Seunghyeon Kim, Hadley D. Sikes (1917553), Hadley D. Sikes   +3 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Clinical development of liposome based drugs: formulation, characterization, and therapeutic efficacy

, 2011
Hsin-I Chang1, Ming-Kung Yeh21Department of Biochemical Science and Technology, National Chia Yi University, Chiayi City, 2Institute of Preventive Medicine, National Defence Medical Center, Sanhsia, Taipei, TaiwanAbstract: Research on liposome ...
Hsin-I Chang, Chang HI, Yeh MK, Ming-Yen Cheng, Ming-Kung Yeh   +4 more
core   +1 more source