Results 21 to 30 of about 65,071 (264)

Macrophage depletion by clodronate liposome attenuates muscle injury and inflammation following exhaustive exercise

Biochemistry and Biophysics Reports, 2016
Exhaustive exercise promotes muscle injury, including myofiber lesions; however, its exact mechanism has not yet been elucidated. In this study, we tested the hypothesis that macrophage depletion by pretreatment with clodronate liposomes alters muscle ...
Noriaki Kawanishi, Tsubasa Mizokami, Hiroyuki Niihara, Koichi Yada, Katsuhiko Suzuki   +4 more
doaj   +1 more source

Pharmacokinetics of liposomal multinutrients versus non-liposomal comparators in a randomized crossover trial

Journal of Functional Foods
Liposomal delivery systems are utilized to enhance the bioavailability of nutrients. In this randomized, double-blind, two-period crossover clinical trial, healthy Korean adults (n = 20) were enrolled to assess the absorption of liposomal multinutrients ...
Young Min Woo, Keun Woo Lee, Andre Kim
doaj   +1 more source

Effects of the protein corona on liposome-liposome and liposome-cell interactions.

International journal of nanomedicine, 2016
A thorough understanding of interactions occurring at the interface between nanocarriers and biological systems is crucial to predict and interpret their biodistribution, targeting, and efficacy, and thus design more effective drug delivery systems. Upon intravenous injection, nanoparticles are coated by a protein corona (PC).
Corbo, C, Molinaro, R, Taraballi, F, Toledano, NE, Sherman, MB, Parodi, A, Salvatore, F, Tasciotti, E   +7 more
openaire   +3 more sources

Hydroxysafflor yellow A-loaded biomimetic liposomes alleviate HHcy-induced atherosclerosis by regulating methylation related autophagy

Materials & Design, 2023
Cardiovascular disease (CVD) caused by atherosclerosis has become a main threaten for human health. As an independent risk factor, hyperhomocysteinemia (HHcy) played an important role in the pathogenesis of atherosclerosis by regulating DNA methylation ...
Yulin Li, Anning Yang, Yue Sun, Dayue Liu, Peidong You, Yaling Zeng, Shangkun Quan, Hongwen Zhang, Huiping Zhang, Shengchao Ma, Yinju Hao, Jiantuan Xiong, Bin Liu, Guizhong Li, Yideng Jiang   +14 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Effect of surface charge of gold nanoparticles on fluorescence amplification of polydiacetylene-based liposomes

Journal of Experimental Nanoscience, 2020
Polydiacetylene (PDA)-based liposome have been attractive as sensory platforms owing to their applicability in simultaneous detection of colorimetric and fluorogenic signals.
Kyu Ha Park, Sangjin Oh, Jeonghyo Kim, Seung Yun Yang, Beum-Soo An, Dae Youn Hwang, Jae Ho Lee, Hong Sung Kim, Jaebeom Lee, Sungbaek Seo   +9 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Liposomal-synthetic-cannabidiol: preliminary translational evidence of efficacy, tolerability and pharmacokinetics following repeated subcutaneous injections in two goats

Frontiers in Pharmacology
Cannabidiol (CBD), the primary non-psychoactive component of Cannabis sativa, has been gaining popularity as an analgesic in treatment of chronic painful conditions. Due to first-pass hepatic metabolism, oral CBD is considered to have low bioavailability.
Yael Shilo-Benjamini, Yael Shilo-Benjamini, Wiessam Abu Ahmad, Dinorah Barasch, Eran Lavy, Daniel Zilbersheid, Yechezkel Barenholz, Ahuva Cern   +7 more
doaj   +1 more source

Effect of surface ligand density on cytotoxicity and pharmacokinetic profile of docetaxel loaded liposomes

Asian Journal of Pharmaceutical Sciences, 2016
Various biotin-modified liposomes incorporated with docetaxel (DTX) were prepared to study the effect of surface biotin density on the pharmacokinetic profile of the liposome. Four types of liposomes such as PEG modified liposome (PDL), 0.5% (mol) biotin
Chun Chu, Ping Xu, Haoyue Zhao, Qing Chen, Dawei Chen, Haiyang Hu, Xiuli Zhao, Mingxi Qiao   +7 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source