Results 41 to 50 of about 83,144 (307)

Liposome-Surface-Initiated ARGET ATRP: Surface Softness Generated by “Grafting from” Polymerization

, 2019
Liposomes are self-assembled vesicles of amphiphilic lipid molecules, which have been investigated as models of cells, or tools for drug delivery systems. In these systems, the surface property of the liposomes plays an important role.
Atsushi Maruyama, Naohiko Shimada, Tsukuru Masuda, Tsukuru Masuda (1487413), Atsushi Maruyama (670527), Naohiko Shimada (1959886)   +5 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Liposomal-synthetic-cannabidiol: preliminary translational evidence of efficacy, tolerability and pharmacokinetics following repeated subcutaneous injections in two goats

Frontiers in Pharmacology
Cannabidiol (CBD), the primary non-psychoactive component of Cannabis sativa, has been gaining popularity as an analgesic in treatment of chronic painful conditions. Due to first-pass hepatic metabolism, oral CBD is considered to have low bioavailability.
Yael Shilo-Benjamini, Yael Shilo-Benjamini, Wiessam Abu Ahmad, Dinorah Barasch, Eran Lavy, Daniel Zilbersheid, Yechezkel Barenholz, Ahuva Cern   +7 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

A multifunctional PEGylated liposomal-encapsulated sunitinib enhancing autophagy, immunomodulation, and safety in renal cell carcinoma

Journal of Nanobiotechnology
Background Sunitinib is a multikinase inhibitor used to treat patients with advanced renal cell carcinoma (RCC). However, sunitinib toxicity makes it a double-edged sword. Potent immune modulation by sunitinib extends to nuclear interactions.
Po-Fu Yueh, Chih-Sheng Chiang, I-Jung Tsai, Yun-Long Tseng, He-Ru Chen, Keng-Li Lan, Fei-Ting Hsu   +6 more
doaj   +1 more source

Effect of surface ligand density on cytotoxicity and pharmacokinetic profile of docetaxel loaded liposomes

Asian Journal of Pharmaceutical Sciences, 2016
Various biotin-modified liposomes incorporated with docetaxel (DTX) were prepared to study the effect of surface biotin density on the pharmacokinetic profile of the liposome. Four types of liposomes such as PEG modified liposome (PDL), 0.5% (mol) biotin
Chun Chu, Ping Xu, Haoyue Zhao, Qing Chen, Dawei Chen, Haiyang Hu, Xiuli Zhao, Mingxi Qiao   +7 more
doaj   +1 more source

Effect of surface charge of gold nanoparticles on fluorescence amplification of polydiacetylene-based liposomes

Journal of Experimental Nanoscience, 2020
Polydiacetylene (PDA)-based liposome have been attractive as sensory platforms owing to their applicability in simultaneous detection of colorimetric and fluorogenic signals.
Kyu Ha Park, Sangjin Oh, Jeonghyo Kim, Seung Yun Yang, Beum-Soo An, Dae Youn Hwang, Jae Ho Lee, Hong Sung Kim, Jaebeom Lee, Sungbaek Seo   +9 more
doaj   +1 more source

Hydroxysafflor yellow A-loaded biomimetic liposomes alleviate HHcy-induced atherosclerosis by regulating methylation related autophagy

Materials & Design, 2023
Cardiovascular disease (CVD) caused by atherosclerosis has become a main threaten for human health. As an independent risk factor, hyperhomocysteinemia (HHcy) played an important role in the pathogenesis of atherosclerosis by regulating DNA methylation ...
Yulin Li, Anning Yang, Yue Sun, Dayue Liu, Peidong You, Yaling Zeng, Shangkun Quan, Hongwen Zhang, Huiping Zhang, Shengchao Ma, Yinju Hao, Jiantuan Xiong, Bin Liu, Guizhong Li, Yideng Jiang   +14 more
doaj   +1 more source

Liposome supported peritoneal dialysis in rat amitriptyline exposure with and without intravenous lipid emulsion.

, 2019
Liposome supported peritoneal dialysis is a recently described technique which may eventually be applicable in the clinical scenario of the intoxicated patient.
Cave, Grant, Harvey, Martyn, Chapman, Robin, Davies, Paul, Wu, Zimei   +4 more
core   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source