Results 41 to 50 of about 149,434 (308)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

A potential of serum anti-C1P IgG antibodies as biomarkers in differential diagnosis of relapsing-remitting multiple sclerosis

Scientific Reports
There is a growing interest in the role of sphingolipids in the background of multiple sclerosis (MS). The goal of this study was to evaluate the serum levels of antibodies against ceramide-1-phosphate (C1P) subclasses and their relationships with ...
Justyna Chojdak-Lukasiewicz, Anna Jakubiak-Augustyn, Zdzislaw M. Szulc, Jerzy Gubernator, Pawel Blazej, Anna Pokryszko-Dragan, Slawomir Budrewicz, Maria Podbielska   +7 more
doaj   +1 more source

Endocytosis of Coacervates into Liposomes

Journal of the American Chemical Society, 2022
Recent studies have shown that the interactions between condensates and biological membranes are of functional importance. Here, we study how the interaction between complex coacervates and liposomes as model systems can lead to wetting, membrane deformation, and endocytosis.
Tiemei Lu, Susanne Liese, Ludo Schoenmakers, Christoph A. Weber, Hiroaki Suzuki, Wilhelm T. S. Huck, Evan Spruijt   +6 more
openaire   +4 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Impact of Liposomes and Ceftriaxone-Entrapped Liposomes on Skin Wound Healing in Rats

Антибиотики и Химиотерапия, 2020
«Empty» liposomes and ceftriaxone (CT)-entrapped liposomes were developed. Lipids of natural origin, i. e. soybean phosphatidyl choline (PhCh) and cholesterol were used for the design.
N. L. Kurilko, A. K. Kiyamov, M. A. Ivanova, E. P. Pashkov, M. T. Aleksandrov, G. M. Sorokoumova, V. I. Shvets   +6 more
doaj  

Acoustic-responsive carbon dioxide-loaded liposomes for efficient drug release

Ultrasonics Sonochemistry, 2023
The role of liposomes as drug carriers has been investigated. Ultrasound-based drug release methods have been developed for on-demand drug delivery. However, the acoustic responses of current liposome carriers result in low drug release efficiency.
Yasuhiko Orita, Susumu Shimanuki, Satoshi Okada, Kentaro Nakamura, Hiroyuki Nakamura, Yoshitaka Kitamoto, Yusuke Shimoyama, Yuta Kurashina   +7 more
doaj   +1 more source

Self-assembled liposomes from amphiphilic electrospun nanofibers

, 2011
Amphiphilic nanofibers composed of the hydrophilic polymer polyvinylpyrrolidone K60 (PVP) and soybean lecithin were fabricated using an electrospinning process.
Yu, Deng-Guang, Zhu, L.M., Nicholas P. Chatterton, S. W. Annie Bligh, Bligh, S. W. Annie, Chatterton, N.P., White, Kenneth, Christopher Branford-White, Deng-Guang Yu, Zhu, Li-Min, Branford-White, C.J., Li-Min Zhu, Yu, D.G., White, K.N., Williams, G.R., Kenneth White, Williams, Gareth R., Branford-White, Christopher, Chatterton, Nicholas P., Bligh, S.W.A., Gareth R. Williams   +20 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Application of a liposomal subunit vaccine in chickens for reduction of Campylobacter gut colonisation

Journal of Veterinary Research
Campylobacter are the most common cause of food poisoning, which manifests itself in diarrhoea of varying severity. Additionally, because of the increasing number of people with immune deficiencies, more frequent serious complications of Campylobacter ...
Łasica Anna, Godlewska Renata, Gubernator Jerzy, Jakubiak-Augustyn Anna, Majewski Paweł, Wyszyńska Agnieszka   +5 more
doaj   +1 more source