Results 151 to 160 of about 93,050 (197)

Sirtuin6 and Lipoxin A4 levels are decreased in severe periodontitis

Clinical Oral Investigations, 2023
Sirtuin6 plays an important role in the regulation of inflammation, homeostasis, and apoptosis, and it has anti-inflammatory effects on several diseases. Lipoxin A4 is a pro-resolving lipid mediator of inflammation and inhibits hypoxia-induced apoptosis and oxidative stress.
Ali Cekici, Selin Sahinkaya, M. Fatih Donmez, Emrah Turkmen, Nur Balci, Hilal Toygar   +5 more
openaire   +2 more sources

Airway lipoxin A4/formyl peptide receptor 2–lipoxin receptor levels in pediatric patients with severe asthma

Journal of Allergy and Clinical Immunology, 2016
Background: Lipoxins are biologically active eicosanoids with anti-inflammatory properties. Lipoxin A4 (LXA4) signaling blocks asthmatic responses in human and experimental model systems.
Stefania La Grutta, Loredana Riccobono, Mark Gjomarkaj   +2 more
exaly   +2 more sources

Total synthesis of lipoxin A4 and lipoxin B4 from butadiene

Tetrahedron Letters, 2000
The total synthesis of LXA4 and LXB4 has been achieved starting from butadiene via palladium catalyzed telomerization. Sharpless catalytic AE and C-2 inversion of the 2(S),3(S)-epoxy alcohols, using Myers CO2/Cs2CO3 procedure, generated the asymmetric centers. The flexibility of the strategy allows an easy access to the linear eicosanoids.
Rodriguez, A, Nomen, M, Spur, B W, Godfroid, J J, Lee, T H   +4 more
openaire   +2 more sources

Lipoxin A ₄ attenuates adipose inflammation

The FASEB Journal, 2012
Aging and adiposity are associated with chronic low‐grade inflammation, which underlies the development of obesity‐associated complications, including type 2 diabetes mellitus (T2DM). The mechanisms underlying adipose inflammation may include macrophage infiltration and activation, which, in turn, affect insulin sensitivity of ...
E. Borgeson, F. C. McGillicuddy, K. A. Harford, N. Corrigan, D. F. Higgins, P. Maderna, H. M. Roche, C. Godson   +7 more
openaire   +2 more sources

Lipoxin A4

1995
Lipoxins are a series of trihydroxylated derivatives of arachidonic acid formed by interaction of the 5- and 15-lipoxygenase pathways in human leukocytes. Lipoxin A4 is involved in the inflammatory process by inhibiting the cytotoxic activity of human natural killer cells and activating neutrophils.
openaire   +1 more source

Total synthesis of novel geometric isomers of lipoxin A4 and lipoxin B4

The Journal of Organic Chemistry, 1989
La synthese stereoselective des composes du titre utilise des reactions basees sur le couplage Pd(0)-Cu(I)
K. C. Nicolaou, B. E. Marron, C. A. Veale, S. E. Webber, C. N. Serhan   +4 more
openaire   +1 more source

Lipoxin A4: The Double-edge Sword in Mice Pregnancy

American Journal of Reproductive Immunology, 2014
To evaluate the role for LXA4 in the pregnancy.We detected the changes of LXA4 and LXA4 biosynthetic enzymes in the mice's pregnancy, blocked LXA4 signaling pathway, managed LXA4 level, and treated LPS-induced mouse abortion model to systematically determine how LXA4 impact pregnancy.The concentrations of LXA4 in serum and uterus were lowest on Days 4 ...
Zhangye, Xu, Feng, Zhao, Huiqiu, Xiang, Ni, Wang, Duyun, Ye, Yinping, Huang   +5 more
openaire   +2 more sources

Inhibition of leukotriene B4 in neutrophils by lipoxins A4 and B4

Agents and Actions, 1991
Lipoxins are derived from the oxygenation products of arachidonic acid in human leukocytes. They have exhibited selective biological effects different from those of other eicosanoids. We have examined the effect of lipoxin A4 and B4 (LXA4, LXB4) on the production of leukotriene B4 (LTB4) in human neutrophils. Cultured human polymorphonuclear leukocytes
P, Conti, M, Reale, R C, Barbacane, M R, Panara, M, Bongrazio   +4 more
openaire   +2 more sources

The Effects of Lipoxin A4 on Airway Responses in Asthmatic Subjects

American Review of Respiratory Disease, 1992
Abstract This study was performed to determine whether lipoxin A4 (LXA4) inhalation in asthmatic subjects has an effect on airways response. Eight subjects (six asthmatic, two normal) attended for bronchial inhalation challenge with LXA4.
P E, Christie, B W, Spur, T H, Lee
openaire   +2 more sources

Aspirin-Triggered 15-Epi-Lipoxin A4 and Stable Analogs of Lipoxin A4 are Potent Inhibitors of Acute Inflammation

1999
Lipoxins (LX) are trihydroxytetraene-containing eicosanoids that are generated within vascular lumen by platelet-leukocyte interactions and at mucosal surfaces by leukocyte-epithelial cell interactions. During these cell-cell interactions, transcellular biosynthetic pathways are used as major routes, and thus, in humans, LX are formed in vivo during ...
C N, Serhan, T, Takano, J F, Maddox
openaire   +2 more sources