Results 151 to 160 of about 5,641 (199)
Lipoxin A<sub>4</sub> yields an electrophilic 15-oxo metabolite that mediates FPR2 receptor-independent anti-inflammatory signaling. [PDF]
J Lipid ResKoudelka A +11 more
europepmc +1 more source
Lipoxin A<sub>4</sub>/FPR2 Signaling Mitigates Ferroptosis of Alveolar Epithelial Cells via NRF2-Dependent Pathway During Lung Ischemia-Reperfusion Injury. [PDF]
FASEB JKollareth DJM +9 more
europepmc +1 more source
The Role of Lipoxin A4 in Exercise-Induced Bronchoconstriction in Asthma
Journal of Asthma, 2008 The pathogenesis of exercise-induced bronchoconstriction in asthma is incompletely understood, and the role of lipoxin A4 has not been investigated.To investigate the involvement of lipoxin A4 in exercise-induced bronchoconstriction.Two groups of children were enrolled in the study: asthmatic children with positive (n = 12) and negative (n = 8 ...
Fulya Tahan +2 more
exaly +5 more sources
Glucocorticoids co-interact with lipoxin A4 via lipoxin A4 receptor (ALX) up-regulation
Biomedicine and Pharmacotherapy, 2007 Lipoxin A(4) (LXA(4)) is an eicosanoid which is produced via lipoxygenases and characteristic of its anti-inflammatory effect in many metabolites of arachidonic acid, which are mostly pro-inflammatory. Glucocorticoids are well known also for their strong anti-inflammatory action but induce 5-lipoxygenase, essential to synthesize leukotrienes, which are
Yousuke Murakami +2 more
exaly +3 more sources
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Sirtuin6 and Lipoxin A4 levels are decreased in severe periodontitis
Clinical Oral Investigations, 2023Sirtuin6 plays an important role in the regulation of inflammation, homeostasis, and apoptosis, and it has anti-inflammatory effects on several diseases. Lipoxin A4 is a pro-resolving lipid mediator of inflammation and inhibits hypoxia-induced apoptosis and oxidative stress.
Ali Cekici +5 more
openaire +2 more sources
Biochemistry, 1995
Lipoxin A4 (LXA4) interacts with high-affinity receptors in human neutrophils and differentiated HL-60 cells. Recently, we characterized a myeloid-derived cDNA that encodes a LXA4 high-affinity receptor (LXA4R) [Fiore, S., Maddox, J. F., Perez, H. D., and Serhan, C. N. (1994) J. Exp. Med.
S, Fiore, C N, Serhan
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Lipoxin A4 (LXA4) interacts with high-affinity receptors in human neutrophils and differentiated HL-60 cells. Recently, we characterized a myeloid-derived cDNA that encodes a LXA4 high-affinity receptor (LXA4R) [Fiore, S., Maddox, J. F., Perez, H. D., and Serhan, C. N. (1994) J. Exp. Med.
S, Fiore, C N, Serhan
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Total synthesis of lipoxin A4 and lipoxin B4 from butadiene
Tetrahedron Letters, 2000The total synthesis of LXA4 and LXB4 has been achieved starting from butadiene via palladium catalyzed telomerization. Sharpless catalytic AE and C-2 inversion of the 2(S),3(S)-epoxy alcohols, using Myers CO2/Cs2CO3 procedure, generated the asymmetric centers. The flexibility of the strategy allows an easy access to the linear eicosanoids.
Rodriguez, A +4 more
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Lipoxin A 4 attenuates adipose inflammation
The FASEB Journal, 2012Aging and adiposity are associated with chronic low‐grade inflammation, which underlies the development of obesity‐associated complications, including type 2 diabetes mellitus (T2DM). The mechanisms underlying adipose inflammation may include macrophage infiltration and activation, which, in turn, affect insulin sensitivity of ...
E. Borgeson +7 more
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1995
Lipoxins are a series of trihydroxylated derivatives of arachidonic acid formed by interaction of the 5- and 15-lipoxygenase pathways in human leukocytes. Lipoxin A4 is involved in the inflammatory process by inhibiting the cytotoxic activity of human natural killer cells and activating neutrophils.
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Lipoxins are a series of trihydroxylated derivatives of arachidonic acid formed by interaction of the 5- and 15-lipoxygenase pathways in human leukocytes. Lipoxin A4 is involved in the inflammatory process by inhibiting the cytotoxic activity of human natural killer cells and activating neutrophils.
openaire +1 more source