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Lipoxins as Modulators of Diseases [PDF]
CellsLipoxins were discovered 40 years ago, and since then, their beneficial roles for human health have been confirmed in numerous studies. These small molecules belong to the eicosanoid class of compounds, which are generated metabolically by lipoxygenases.
Herney García-Perdomo +2 more
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Advances in the role of specialized pro-resolving mediators in periodontitis [PDF]
Frontiers in ImmunologyPeriodontitis is a chronic inflammatory disease driven by dysregulated host–microbial interactions and failure of endogenous inflammation resolution, leading to progressive destruction of periodontal tissues.
Huiting Hu +4 more
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Specialized Pro-Resolving Mediators at the Ocular Surface: Biosynthesis, Mechanisms, and Therapeutic Potential [PDF]
BiologySpecialized pro-resolving mediators (SPMs) are endogenous lipid mediators that actively orchestrate the resolution of inflammation rather than relying solely on broad suppression of inflammatory signaling.
Siddharth Gandhi +3 more
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Lipoxins in the Nervous System: Brighter Prospects for Neuroprotection
Frontiers in Pharmacology, 2022 Lipoxins (LXs) are generated from arachidonic acid and are involved in the resolution of inflammation and confer protection in a variety of pathological processes.
Mingyue Fan
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Resolving Inflammation in CKD: The Potential of SPMs and Omega-3 Derivatives as Biomarkers and Therapeutics [PDF]
BiomedicinesChronic kidney disease (CKD) affects more than 10% of the population and is associated with a persistent, low-grade inflammatory state that accelerates tubulointerstitial fibrosis, worsens prognosis, and increases cardiovascular risk. This review aims to
Beata Franczyk +8 more
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Scientific World Journal, The, 2002 It is well appreciated that lipid-derived mediators play key roles in inflammation and many other physiologic responses where multicellular processes are involved.
Charles N Serhan
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Advances in the Chemistry and Biology of Specialised Pro-Resolving Mediators (SPMs) [PDF]
MoleculesThis review article assembles key recent advances in the synthetic chemistry and biology of specialised pro-resolving mediators (SPMs). The major medicinal chemistry developments in the design, synthesis and biological evaluation of synthetic SPM ...
Lucy Byrne, Patrick J. Guiry
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Infection, Inflammation, and Immunity in Sepsis
Biomolecules, 2023 Sepsis is triggered by microbial infection, injury, or even major surgery. Both innate and adaptive immune systems are involved in its pathogenesis. Cytoplasmic presence of DNA or RNA of the invading organisms or damaged nuclear material (in the form of ...
Undurti N. Das
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Frontiers in Pharmacology, 2023 Lipoxygenases (LOX) transform arachidonic acid (AA, C20:4) and docosahexaenoic acid (DHA, C22:6) into bioactive lipid mediators (LMs) that comprise not only pro-inflammatory leukotrienes (LTs) but also the specialized pro-resolving mediators (SPMs) that ...
Philipp Dahlke +5 more
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SOCS2-induced proteasome-dependent TRAF6 degradation: a common anti-inflammatory pathway for control of innate immune responses. [PDF]
PLoS ONE, 2012 Pattern recognition receptors and receptors for pro-inflammatory cytokines provide critical signals to drive the development of protective immunity to infection. Therefore, counter-regulatory pathways are required to ensure that overwhelming inflammation
Cortez McBerry +4 more
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