Results 1 to 10 of about 167,987,948 (249)

Resolution therapy: Harnessing efferocytic macrophages to trigger the resolution of inflammation [PDF]

Frontiers in Immunology, 2022
Several chronic inflammatory diseases are associated with non-resolving inflammation. Conventional anti-inflammatory drugs fail to completely cure these diseases.
Philippe Saas, Mathieu Vetter, Melissa Maraux, Francis Bonnefoy, Francis Bonnefoy, Sylvain Perruche, Sylvain Perruche   +6 more
doaj   +4 more sources

Resolution of inflammation during rheumatoid arthritis [PDF]

Frontiers in Cell and Developmental Biology
Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes synovial joint inflammation as well as bone destruction and erosion, typically characterized by joint pain, swelling, and stiffness, with complications and persistent pain after ...
Xiaoou Ye, Dan Ren, Qingyuan Chen, Jiquan Shen, Jiquan Shen, Bo Wang, Bo Wang, Songquan Wu, Hongliang Zhang   +8 more
doaj   +2 more sources

Editorial: Eicosanoids and cytokines: Resolution of inflammation [PDF]

Frontiers in Pharmacology, 2022
Jun-Yan Liu
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Role of Specialized Pro-Resolving Mediators in Neuropathic Pain

Frontiers in Pharmacology, 2021
Inflammation and neuroinflammation are critical mechanisms in the generation of neuropathic pain that is experienced in several chronic diseases. The aberrant inflammation that triggers this pathophysiologic process can be tracked down to an exacerbated ...
Alessandro Leuti, Alessandro Leuti, Marina Fava, Marina Fava, Niccolò Pellegrini, Mauro Maccarrone, Mauro Maccarrone   +6 more
doaj   +1 more source

Efferocytosis during Skeletal Muscle Regeneration

Cells, 2021
Efferocytosis, i.e., engulfment of dead cells by macrophages, is a crucial step during tissue repair after an injury. Efferocytosis delineates the transition from the pro-inflammatory phase of the inflammatory response to the recovery phase that ensures ...
Gaëtan Juban, Bénédicte Chazaud
doaj   +1 more source

Stimulating the Resolution of Inflammation Through Omega-3 Polyunsaturated Fatty Acids in COVID-19: Rationale for the COVID-Omega-F Trial

Frontiers in Physiology, 2021
Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). SARS-CoV-2 triggers an immune response with local inflammation in the lung, which may extend to a systemic hyperinflammatory reaction.
Hildur Arnardottir, Hildur Arnardottir, Sven-Christian Pawelzik, Sven-Christian Pawelzik, Ulf Öhlund Wistbacka, Gonzalo Artiach, Gonzalo Artiach, Robin Hofmann, Robin Hofmann, Ingalill Reinholdsson, Frieder Braunschweig, Per Tornvall, Per Tornvall, Dorota Religa, Dorota Religa, Magnus Bäck, Magnus Bäck   +16 more
doaj   +1 more source

11,12-EET Regulates PPAR-γ Expression to Modulate TGF-β-Mediated Macrophage Polarization

Cells, 2023
Macrophages are highly plastic immune cells that can be reprogrammed to pro-inflammatory or pro-resolving phenotypes by different stimuli and cell microenvironments.
Xiaoming Li, Sebastian Kempf, Stefan Günther, Jiong Hu, Ingrid Fleming   +4 more
doaj   +1 more source

Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators—What is the Evidence so far?

Frontiers in Pharmacology, 2022
Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of arachidonic acid 12- and 15-lipoxygenating paralogues (15-LO1, ALOX15; 15 ...
Nils Helge Schebb, Hartmut Kühn, Astrid S. Kahnt, Katharina M. Rund, Valerie B. O’Donnell, Nicolas Flamand, Marc Peters-Golden, Per-Johan Jakobsson, Karsten H. Weylandt, Nadine Rohwer, Nadine Rohwer, Robert C. Murphy, Gerd Geisslinger, Gerd Geisslinger, Garret A. FitzGerald, Julien Hanson, Julien Hanson, Claes Dahlgren, Mohamad Wessam Alnouri, Stefan Offermanns, Stefan Offermanns, Dieter Steinhilber, Dieter Steinhilber   +22 more
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A 17-kDa Fragment of Lactoferrin Associates With the Termination of Inflammation and Peptides Within Promote Resolution

Frontiers in Immunology, 2018
During the resolution of inflammation, macrophages engulf apoptotic polymorphonuclear cells (PMN) and can accumulate large numbers of their corpses. Here, we report that resolution phase macrophages acquire the neutrophil-derived glycoprotein lactoferrin
Aviv Lutaty, Aviv Lutaty, Soaad Soboh, Soaad Soboh, Sagie Schif-Zuck, Sagie Schif-Zuck, Orly Zeituni-Timor, Orly Zeituni-Timor, Ran Rostoker, Ran Rostoker, Malgorzata J. Podolska, Christine Schauer, Martin Herrmann, Luis E. Muñoz, Amiram Ariel, Amiram Ariel   +15 more
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Molecular and Cellular Differences in Cardiac Repair of Male and Female Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Leukocyte‐directed biosynthesis of specialized proresolving mediators (SPMs) orchestrates physiological inflammation after myocardial infarction.
Amanda B. Pullen, Vasundhara Kain, Charles N. Serhan, Ganesh V. Halade   +3 more
doaj   +1 more source