Results 1 to 10 of about 11,135 (204)

Efferocytosis in the Central Nervous System [PDF]

Frontiers in Cell and Developmental Biology, 2021
The effective clearance of apoptotic cells is essential for maintaining central nervous system (CNS) homeostasis and restoring homeostasis after injury.
Jiayi Zhao, Weiqi Zhang, Tingting Wu, Hongyi Wang, Jialiang Mao, Jian Liu, Ziheng Zhou, Xianfeng Lin, Huige Yan, Qingqing Wang   +9 more
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The ErbB-tyrosine kinase inhibitor, neratinib, has anti-inflammatory effects in multimorbidity by increasing macrophage efferocytosis via the upregulation of MerTK [PDF]

Journal of Inflammation
Background Chronic inflammatory disease is responsible for huge and increasing global mortality and morbidity. Unregulated inflammatory cells, including neutrophils and macrophages, are major drivers of chronic inflammatory disease. Efferocytosis plays a
Kieran A. Bowden, Carl Wright, Susan Clark, Tomas Fernandez Correa, Simon A. Johnston, Helen M. Marriott, Sheila E. Francis, Lynne R. Prince   +7 more
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Efferocytosis: Signaling Pathways and New Therapeutic Strategies for Diseases [PDF]

MedComm
Efferocytosis—the phagocytic clearance of apoptotic cells (ACs)—is essential for maintaining tissue homeostasis, immune tolerance, and inflammation resolution.
Lei Wang, Jingjing Ge, Zehua Wang, Yihua Fang, Yongxu Jia, Ruyue Zhang, Yanru Qin   +6 more
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Macrophage efferocytosis promotes inflammation resolution and accelerates wound healing [PDF]

Communications Biology
Skin trauma, particularly chronic non-healing wounds, imposes significant economic and physical burdens on patients and their families. A defining feature of these wounds is persistent dysregulated inflammation, with macrophage efferocytosis playing a ...
Jia Gao, Dong Zhu, Jian Wang, Malak Ihtisham Ullah Khan, Aijun Zhang, Xiaokang Wen, Qiang Li, Peisheng Jin, Caiqi Shen   +8 more
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Primed mesenchymal stem cells attenuate schistosomiasis fibrosis by enhancing macrophage subset switching and efferocytosis via Itgb2-Rac1 axis [PDF]

Cell Death Discovery
The pathological hallmark of schistosomiasis is egg-induced granulomatous inflammation and the subsequent fibrosis in the liver; and mesenchymal stem cells have been explored for the treatment of schistosomiasis fibrosis.
Junxia Lei, Yaojia Ren, Zebin Chen, Wanxian Huang, Meiyining Xu, Zhongdao Wu   +5 more
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Macrophage COX2 Mediates Efferocytosis, Resolution Reprogramming, and Intestinal Epithelial RepairSummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background and Aims: Phagocytosis (efferocytosis) of apoptotic neutrophils by macrophages anchors the resolution of intestinal inflammation. Efferocytosis prevents secondary necrosis and inhibits further inflammation, and also reprograms macrophages to ...
David Meriwether, Anthony E. Jones, Julianne W. Ashby, R. Sergio Solorzano-Vargas, Nasrin Dorreh, Shoreh Noori, Victor Grijalva, Andréa B. Ball, Margarita Semis, Ajit S. Divakaruni, Julia J. Mack, Harvey R. Herschman, Martin G. Martin, Alan M. Fogelman, Srinivasa T. Reddy   +14 more
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Defective efferocytosis of vascular cells in heart disease

Frontiers in Cardiovascular Medicine, 2022
The efficient phagocytic clearance of dying cells and apoptotic cells is one of the processes that is essential for the maintenance of physiologic tissue function and homeostasis, which is termed “efferocytosis.” Under normal conditions, “find me” and ...
Bandana Singh, Kathryn Li, Kui Cui, Qianman Peng, Douglas B. Cowan, Da-Zhi Wang, Kaifu Chen, Hong Chen   +7 more
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Efferocytosis and Its Role in Inflammatory Disorders

Frontiers in Cell and Developmental Biology, 2022
Efferocytosis is the effective clearance of apoptotic cells by professional and non-professional phagocytes. The process is mechanically different from other forms of phagocytosis and involves the localization, binding, internalization, and degradation ...
Yun Ge, Man Huang, Yong-ming Yao, Yong-ming Yao   +3 more
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Identification of efferocytosis-related subtypes in gliomas and elucidating their characteristics and clinical significance

Frontiers in Cell and Developmental Biology, 2023
Introduction: Gliomas, the most prevalent tumors of the central nervous system, are known for their aggressive nature and poor prognosis. The heterogeneity among gliomas leads to varying responses to the same treatments, even among similar glioma types ...
Mengge Gao, Jinsheng Huang, Bo Yang, Qiong Liu, Miaoqing Luo, Biying Yang, Xujia Li, Xiaofang Liu   +7 more
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Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis

Frontiers in Endocrinology, 2021
Atherosclerosis (AS) is the main pathological basis for the development of cardio-cerebrovascular diseases. Abnormal accumulation of apoptotic and necrotic cells resulted in plaque enlargement, necrotic core formation and plaque rupture in AS.
Lili Wang, Lili Wang, Lili Wang, Hongxia Li, Hongxia Li, Hongxia Li, Yuhan Tang, Yuhan Tang, Yuhan Tang, Ping Yao, Ping Yao, Ping Yao   +11 more
doaj   +1 more source