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Efferocytosis in the Central Nervous System [PDF]
Frontiers in Cell and Developmental Biology, 2021 The effective clearance of apoptotic cells is essential for maintaining central nervous system (CNS) homeostasis and restoring homeostasis after injury.
Tingting Wu, Hongyi Wang, Qingqing Wang
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Macrophage efferocytosis in pregnancy and pregnancy complications [PDF]
Reproduction and FertilityEfferocytosis is a vital process during early placental development that removes apoptotic cells generated through decidualisation and controls inflammation.
Chloe A Brady, Kylie B R Belchamber
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Macrophage COX2 Mediates Efferocytosis, Resolution Reprogramming, and Intestinal Epithelial RepairSummary [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2022 Background and Aims: Phagocytosis (efferocytosis) of apoptotic neutrophils by macrophages anchors the resolution of intestinal inflammation. Efferocytosis prevents secondary necrosis and inhibits further inflammation, and also reprograms macrophages to ...
David Meriwether +14 more
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Efferocytosis and Its Role in Inflammatory Disorders
Frontiers in Cell and Developmental Biology, 2022 Efferocytosis is the effective clearance of apoptotic cells by professional and non-professional phagocytes. The process is mechanically different from other forms of phagocytosis and involves the localization, binding, internalization, and degradation ...
Man Huang, Yong-Ming Yao, Yun Ge
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Enhancement of efferocytosis through biased FPR2 signaling attenuates intestinal inflammation
EMBO Molecular Medicine, 2023 Efficient clearance of dying cells (efferocytosis) is an evolutionarily conserved process for tissue homeostasis. Genetic enhancement of efferocytosis exhibits therapeutic potential for inflammation resolution and tissue repair.
Lei Wang, Han-Ming Shen, Qiwen Liao
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Efferocytosis and Its Associated Cytokines: A Light on Non-tumor and Tumor Diseases?
Molecular Therapy - Oncolytics, 2020 Billions of cells undergo turnover and die via apoptosis throughout our lifetime. A prompt clearance of these apoptotic cells and debris by phagocytic cells, a process known as efferocytosis, is important in maintaining tissue homeostasis.
Anwen Shao, Yiding Chen, Xiaochen Wang
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Efferocytosis: Signaling Pathways and New Therapeutic Strategies for Diseases [PDF]
MedCommEfferocytosis—the phagocytic clearance of apoptotic cells (ACs)—is essential for maintaining tissue homeostasis, immune tolerance, and inflammation resolution.
Lei Wang +6 more
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Macrophage efferocytosis promotes inflammation resolution and accelerates wound healing [PDF]
Communications BiologySkin trauma, particularly chronic non-healing wounds, imposes significant economic and physical burdens on patients and their families. A defining feature of these wounds is persistent dysregulated inflammation, with macrophage efferocytosis playing a ...
Jia Gao +8 more
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Defective efferocytosis of vascular cells in heart disease
Frontiers in Cardiovascular Medicine, 2022 The efficient phagocytic clearance of dying cells and apoptotic cells is one of the processes that is essential for the maintenance of physiologic tissue function and homeostasis, which is termed “efferocytosis.” Under normal conditions, “find me” and ...
Bandana Singh +7 more
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Frontiers in Cell and Developmental Biology, 2023 Introduction: Gliomas, the most prevalent tumors of the central nervous system, are known for their aggressive nature and poor prognosis. The heterogeneity among gliomas leads to varying responses to the same treatments, even among similar glioma types ...
Mengge Gao +7 more
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