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Efferocytosis in health and disease
Nature Reviews Immunology, 2019 The clearance of apoptotic cells by professional and non-professional phagocytes - a process termed 'efferocytosis' - is essential for the maintenance of tissue homeostasis. Accordingly, defective efferocytosis underlies a growing list of chronic inflammatory diseases. Although much has been learnt about the mechanisms of apoptotic cell recognition and
Amanda C Doran +2 more
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Mechanisms and Consequences of Defective Efferocytosis in Atherosclerosis
Frontiers in Cardiovascular Medicine, 2018Arif Yurdagul +2 more
exaly
Current Biology, 2016 Kumar and Birge introduce efferocytosis - the process by which dead or dying cells are engulfed and digested by phagocytes.
Sushil, Kumar, Raymond B, Birge
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Efferocytosis and Respiratory Disease
International Journal of Molecular Sciences, 2023 Cells are the smallest units that make up living organisms, which constantly undergo the processes of proliferation, differentiation, senescence and death. Dead cells need to be removed in time to maintain the homeostasis of the organism and keep it healthy. This process is called efferocytosis.
Wenxue Zheng +9 more
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Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis
Hepatology, EarlyView., 2022 EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu +16 more
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