Results 21 to 30 of about 11,135 (204)
Immunity, Inflammation and Disease, 2023 Efferocytosis can resolve airway inflammation and enhance airway tolerance in allergic asthma. While previous work has reported that progranulin (PGRN) regulated macrophage efferocytosis, but it is unclear whether PGRN‐mediated efferocytosis is ...
Qi Huang +9 more
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Efferocytosis Is an Innate Antibacterial Mechanism [PDF]
Cell Host & Microbe, 2012 Mycobacterium tuberculosis persists within macrophages in an arrested phagosome and depends upon necrosis to elude immunity and disseminate. Although apoptosis of M. tuberculosis-infected macrophages is associated with reduced bacterial growth, the bacteria are relatively resistant to other forms of death, leaving the mechanism underlying this ...
Martin, Constance J. +8 more
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Internalization of apoptotic cells during efferocytosis requires Mertk-mediated calcium influx
Cell Death and Disease, 2023 Phagocytosis of apoptotic cells, called efferocytosis, requires calcium inside and outside of phagocytes. Due to its necessity, calcium flux is sophisticatedly modulated, and the level of intracellular calcium in phagocytes is ultimately elevated during ...
Susumin Yang +8 more
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Efferocytosis in health and disease
Nature Reviews Immunology, 2019 The clearance of apoptotic cells by professional and non-professional phagocytes - a process termed 'efferocytosis' - is essential for the maintenance of tissue homeostasis. Accordingly, defective efferocytosis underlies a growing list of chronic inflammatory diseases. Although much has been learnt about the mechanisms of apoptotic cell recognition and
Amanda C. Doran +2 more
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The Role of Efferocytosis in Autoimmune Diseases [PDF]
Frontiers in Immunology, 2018 L'apoptose se produit en continu pour des millions de cellules ainsi que l'élimination active des débris apoptotiques afin de maintenir l'homéostasie tissulaire. À cet égard, l'efférocytose, c'est-à-dire le processus d'élimination des cellules mortes, est orchestrée par l'exposition cellulaire d'un ensemble de signaux « trouve-moi », « mange-moi » et «
Fereshte Abdolmaleki +9 more
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Efferocytosis of Pathogen-Infected Cells [PDF]
Frontiers in Immunology, 2017 The prompt and efficient clearance of unwanted and abnormal cells by phagocytes is termed efferocytosis and is crucial for organism development, maintenance of tissue homeostasis, and regulation of the immune system. Dying cells are recognized by phagocytes through pathways initiated via "find me" signals, recognition via "eat me" signals and down ...
Karaji, N, Sattentau, Q
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Mechanisms and Consequences of Defective Efferocytosis in Atherosclerosis
Frontiers in Cardiovascular Medicine, 2018 Efficient clearance of apoptotic cells, termed efferocytosis, critically regulates normal homeostasis whereas defective uptake of apoptotic cells results in chronic and non-resolving inflammatory diseases, such as advanced atherosclerosis.
Arif Yurdagul +12 more
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Efferocytosis during Skeletal Muscle Regeneration
Cells, 2021 Efferocytosis, i.e., engulfment of dead cells by macrophages, is a crucial step during tissue repair after an injury. Efferocytosis delineates the transition from the pro-inflammatory phase of the inflammatory response to the recovery phase that ensures ...
Gaëtan Juban, Bénédicte Chazaud
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The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
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Enhancement of efferocytosis through biased FPR2 signaling attenuates intestinal inflammation
EMBO Molecular Medicine, 2023 Efficient clearance of dying cells (efferocytosis) is an evolutionarily conserved process for tissue homeostasis. Genetic enhancement of efferocytosis exhibits therapeutic potential for inflammation resolution and tissue repair.
Ming‐Yue Wu +18 more
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