Results 21 to 30 of about 14,265 (225)
The role of efferocytosis in inflammatory bowel disease [PDF]
Frontiers in ImmunologyEfferocytosis is the process by which various phagocytes clear apoptotic cells. In recent years, an increasing body of evidence has emphasized the importance of efferocytosis in maintaining internal homeostasis. Intestinal macrophages play a crucial role
Yi-Qian Liu +3 more
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Efferocytosis: The Silent Guardian of Tissue Homeostasis and Cardiovascular Health
Journal of Cardiovascular Development and DiseaseRapid and effective clearance of apoptotic cells, known as efferocytosis, is essential for maintaining tissue homeostasis. Efferocytosis removes apoptotic cells before the occurrence of membrane rupture from which the cell contents, often inflammatory ...
Wenting Peng +4 more
doaj +2 more sources
Consequence of alcohol intoxication-mediated efferocytosis impairment [PDF]
Frontiers in ImmunologyAlcohol ingestion is a widespread habituation that evolved along with a growing population, altering physiological conditions through immunomodulatory function.
Subhashini Brahadeeswaran +1 more
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Immunomodulatory effect of efferocytosis at the maternal–fetal interface
Cell Communication and SignalingEfferocytosis is a mechanism by which phagocytes efficiently clear apoptotic cells, averting their secondary necrosis and the subsequent release of potentially immunogenic or cytotoxic substances that can trigger strong immune and inflammatory responses.
Hui Tao +6 more
doaj +2 more sources
Phytochemical-mediated efferocytosis and autophagy in inflammation control
Cell Death DiscoveryEfferocytosis, the clearance of apoptotic cells, is a critical process that maintains tissue homeostasis and immune regulation. Defective efferocytosis is linked to the development of chronic inflammatory conditions, including atherosclerosis ...
Asma Vafadar +4 more
doaj +2 more sources
AHR-Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg-Mediated Macrophage Efferocytosis. [PDF]
Adv Sci (Weinh)Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zhu Z +6 more
europepmc +2 more sources
Macrophage Lipid Homeostasis Drives IVDD via a Senescence-Dependent Impairment of Efferocytosis. [PDF]
Cell ProlifIntervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Wang J +12 more
europepmc +2 more sources
Current Biology, 2016 Kumar and Birge introduce efferocytosis - the process by which dead or dying cells are engulfed and digested by phagocytes.
Sushil, Kumar, Raymond B, Birge
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Potential Mechanisms and Effects of Efferocytosis in Atherosclerosis
Frontiers in Endocrinology, 2021 Atherosclerosis (AS) is the main pathological basis for the development of cardio-cerebrovascular diseases. Abnormal accumulation of apoptotic and necrotic cells resulted in plaque enlargement, necrotic core formation and plaque rupture in AS.
Lili Wang +11 more
doaj +1 more source
Cell Communication and Signaling, 2023 Background The inflammatory response induced by intestinal ischaemia‒reperfusion injury (I/R) is closely associated with infectious complications and mortality in critically ill patients, and the timely and effective clearance of apoptotic cells is an ...
Xiao-Hu Zhao +8 more
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