Efferocytosis in myocardial infarction: the regulatory core from inflammation resolution to cardiac repair. [PDF]
Front ImmunolEffective tissue repair after acute myocardial infarction (MI) critically depends on the timely and orderly resolution of inflammation. This review systematically elaborates the core “directorial” role of efferocytosis—the immunologically silent ...
Meng C +6 more
europepmc +2 more sources
Phagocytosis of Apoptotic Cells in Resolution of Inflammation
Frontiers in Immunology, 2020 Efficient inflammation resolution is important not only for the termination of the inflammatory response but also for the restoration of tissue integrity. An integral process to resolution of inflammation is the phagocytosis of dying cells by macrophages,
George Hajishengallis +2 more
exaly +3 more sources
Integrated pro-resolving mechanisms: a new dimension for optimizing anti-inflammatory therapy in asthma - a review of impaired inflammation resolution in airway remodeling. [PDF]
Front ImmunolThe core pathology of asthma involves not only inflammation amplification but also a systemic failure of inflammation resolution programs. This review first summarizes the Specialized Pro-resolving Mediators (SPM) family, efferocytosis, and their ...
Zhang B +5 more
europepmc +2 more sources
The antiprotease Spink7 promotes inflammation resolution by modulating multiple proteases activities during wound healing. [PDF]
Clin Transl MedBackground Effective control of inflammation is crucial for the healing of cutaneous wounds, but the molecular mechanisms governing inflammation resolution during wound closure are still not yet clear.
Zhao N +7 more
europepmc +2 more sources
What Mediates the Inflammation Resolution? [PDF]
Function (Oxf), 2023 Schebb NH, Steinhilber D.
europepmc +2 more sources
The Resolution Approach to Cystic Fibrosis Inflammation
Frontiers in Pharmacology, 2020 Despite the high expectations associated with the recent introduction of CFTR modulators, airway inflammation still remains a relevant clinical issue in cystic fibrosis (CF).
Antonio Recchiuti +3 more
doaj +1 more source
Lung Inflammation Resolution by RvD1 and RvD2 in a Receptor-Dependent Manner
Pharmaceutics, 2023 Inflammation resolution is an active process via specialized pro-resolving mediators (SPMs) to fight invading microbes and repair tissue injury. RvD1 and RvD2 are SPMs produced from DHA during inflammation responses and show a benefit in treating ...
Jin Gao, Yujie Su, Zhenjia Wang
doaj +1 more source
Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease
eLife, 2022 Host immune responses contribute to dengue’s pathogenesis and severity, yet the possibility that failure in endogenous inflammation resolution pathways could characterise the disease has not been contemplated. The pro-resolving protein Annexin A1 (AnxA1)
Vivian Vasconcelos Costa +21 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Type 2 innate lymphocytes (ILC2s), promoting inflammation resolution, was a potential target for rheumatoid arthritis (RA) treatment. Our previous studies confirmed that R. astragali and R.
Guiyu Feng +9 more
doaj +1 more source
Frontiers in Immunology, 2022 Cardiovascular and metabolic diseases (CVMDs) are a leading cause of death worldwide and impose a major socioeconomic burden on individuals and healthcare systems, underscoring the urgent need to develop new drug therapies.
Mengmeng Zhao +13 more
doaj +1 more source