Results 1 to 10 of about 258,864 (288)
Defects in Macrophage Reprogramming in Cancer Therapy: The Negative Impact of PD-L1/PD-1 [PDF]
Frontiers in Immunology, 2021 Classically activated M1 macrophages and alternatively activated M2 macrophages are two polarized subsets of macrophages at the extreme ends of a constructed continuum.
Hao Cai
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Cancer ControlBackground Macrophages are a critical component of the innate immune system, derived from monocytes, with significant roles in anti-inflammatory and anti-tumour activities.
Weisong Zhang
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Macrophage Polarization, Metabolic Reprogramming, and Inflammatory Effects in Ischemic Heart Disease [PDF]
Frontiers in Immunology, 2022 Macrophages are highly plastic cells, and the polarization-activating actions that represent their functional focus are closely related to metabolic reprogramming.
Chun Li, Qiong Deng, Jianteng Dong
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Lactate and lactylation in macrophage metabolic reprogramming: current progress and outstanding issues [PDF]
Frontiers in ImmunologyIt is commonly known that different macrophage phenotypes play specific roles in different pathophysiological processes. In recent years, many studies have linked the phenotypes of macrophages to their characteristics in different metabolic pathways ...
Bangjun Xu, Yi Liu, Ning Li, Qing Geng
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Macrophage Reprogramming: Emerging Molecular Therapeutic Strategies for Nephrolithiasis [PDF]
BiomoleculesNephrolithiasis, predominantly driven by calcium oxalate (CaOx) crystal deposition, poses a significant global health burden due to its high prevalence and recurrence rates and limited preventive/therapeutic options.
Meng Shu +7 more
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GSK3β Inhibition Prevents Macrophage Reprogramming by High-Dose Methotrexate
Journal of Innate Immunity, 2022 Methotrexate (MTX) is an antifolate drug used as a chemotherapeutic agent for acute lymphoblastic leukemia, where MTX improves patients’ prognosis. Macrophage reprogramming is being increasingly assessed as an antitumor therapeutic strategy. However, and
Israel Ríos +9 more
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Macrophage metabolic reprogramming ameliorates diabetes-induced microvascular dysfunction
Redox BiologyMacrophages play an important role in the development of vascular diseases, with their homeostasis closely linked to metabolic reprogramming. This study aims to explore the role of circular RNA-mediated epigenetic remodeling in maintaining macrophage ...
Jin Yao, Xiu-Miao Li, Qiu-Yang Zhang
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Clinical and Translational Medicine, 2023 Macrophages are the central immune cells in atherosclerosis (AS) and play a critical role in the initiation, progression and invasion of atherosclerotic plaques.
Xiaoyan Zhu
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Extracellular vesicles for macrophage reprogramming: an emerging paradigm in immunomodulatory therapeutics [PDF]
Journal of Biological EngineeringMacrophages are pivotal regulators of immunity, and due to their ability to differentiate into either pro-inflammatory (M1) or anti-inflammatory (M2) phenotypes with remarkable plasticity, they can be used as strategies for treating diseases ranging from
Ha Young Jo +4 more
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Frontiers in ImmunologyMacrophage metabolic reprogramming refers to the process by which macrophages adjust their physiological pathways to meet survival and functional demands in different immune microenvironments.
Shengjun Wang, Peiqi Xu
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