Kaposin-B enhances the PROX1 mRNA stability during lymphatic reprogramming of vascular endothelial cells by Kaposi's sarcoma herpes virus. [PDF]
, 2010 Kaposi's sarcoma (KS) is the most common cancer among HIV-positive patients. Histogenetic origin of KS has long been elusive due to a mixed expression of both blood and lymphatic endothelial markers in KS tumor cells.
Kafka, Darren +37 more
core +1 more source
Functional plasticity of macrophages: in situ reprogramming of tumor-associated macrophages [PDF]
Journal of Leukocyte Biology, 2009 Abstract Functionally polarized macrophages in chronic pathologies are highly adaptable cells displaying a functional response to tissue signals, which response can be reprogrammed to therapeutic advantage. The extent to which the functional heterogeneity of Mφs is dependent on the differentiation of functional sublineages
Robert D, Stout +2 more
openaire +2 more sources
Proton irradiation orchestrates macrophage reprogramming through NFκB signaling [PDF]
, 2018 Tumor-associated macrophages (TAMs) represent potential targets for anticancer treatments as these cells play critical roles in tumor progression and frequently antagonize the response to treatments.
Wera, Anne-Catherine +11 more
core +1 more source
Research progress on the effect of metabolic reprogramming on macrophage polarization [PDF]
Journal of Hebei University of Science and TechnologyThe pathogenesis of inflammatory diseases involves complex cellular cascades within tissues, where macrophages play a pivotal role. These cells exhibit remarkable phenotypic plasticity and can polarize into M1 or M2 types depending on the stage of ...
Jiangtao SHAO +5 more
doaj +1 more source
Trajectories of macrophage ontogeny and reprogramming in cancer [PDF]
iScienceTumor-associated macrophages (TAMs) often manifest immunosuppressive and tumor-promoting phenotypes contributing to immunotherapy resistance. Dicer1 inactivation in TAMs (DKO) prompts their immunostimulatory activation, enabling effective immunotherapy in mouse cancer models.
Duval, Florent +8 more
openaire +5 more sources
Autophagic reprogramming of bone marrow–derived macrophages
Immunologic Research, 2022 Abstract Macro-autophagy is a highly conserved catabolic process among eukaryotes affecting macrophages. This work studies the genetic regulatory network involving the interplay between autophagy and macrophage polarization (activation). Autophagy-related genes (Atgs) and differentially expressed genes (DEGs) of macrophage polarization (M1–M2) were ...
Mayada Mazher +4 more
openaire +2 more sources
Reprogramming of macrophage metabolism and inflammatory injuries in chronic kidney disease
Linchuang shenzangbing zazhiMacrophages are important cells involved in inflammatory damage in chronic kidney disease. The characteristic alteration of macrophage function due to changes in the local microenvironment is referred to as macrophage reprogramming.
Jie Lyu +4 more
doaj +1 more source
Glycolytic reprogramming in macrophages and MSCs during inflammation
Frontiers in Immunology, 2023 BackgroundDysregulated inflammation is associated with many skeletal diseases and disorders, such as osteolysis, non-union of fractures, osteonecrosis, osteoarthritis and orthopaedic infections. We previously showed that continuous infusion of lipopolysaccharide (LPS) contaminated polyethylene particles (cPE) caused prolonged inflammation and impaired ...
Xueping Li +18 more
openaire +3 more sources
Unleashing Ascl1 Exploring Cross-Lineage Potential in Reprogramming and Regenerative Frontiers
, 2023 In the era of stem cell research and regenerative medicine, understanding the regulatory networks that drive cellular reprogramming is fundamental.
Lund University. +1 more
core +1 more source
Pneumonia recovery reprograms the alveolar macrophage pool [PDF]
JCI Insight, 2020 Community-acquired pneumonia is a widespread disease with significant morbidity and mortality. Alveolar macrophages are tissue-resident lung cells that play a crucial role in innate immunity against bacteria that cause pneumonia.
Antoine Guillon +16 more
openaire +2 more sources