Results 11 to 20 of about 258,864 (288)

Crotoxin Modulates Macrophage Phenotypic Reprogramming

Toxins, 2023
Macrophage plasticity is a fundamental feature of the immune response since it favors the rapid and adequate change of the functional phenotype in response to the pathogen or the microenvironment. Several studies have shown that Crotoxin (CTX), the major
Camila Lima Neves, Christiano Marcello Vaz Barbosa, Priscila Andrade Ranéia-Silva, Eliana L. Faquim-Mauro, Sandra Coccuzzo Sampaio   +4 more
doaj   +4 more sources

Macrophage reprogramming for therapy [PDF]

Immunology, 2021
SummaryDysfunction of the immune system underlies a plethora of human diseases, requiring the development of immunomodulatory therapeutic intervention. To date, most strategies employed have been focusing on the modification of T lymphocytes, and although remarkable improvement has been obtained, results often fall short of the intended outcome. Recent
Bart, Valentina MT, Pickering, Robert J, Taylor, Philip R, Ipseiz, Natacha   +3 more
openaire   +7 more sources

Macrophage COX2 Mediates Efferocytosis, Resolution Reprogramming, and Intestinal Epithelial RepairSummary [PDF]

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background and Aims: Phagocytosis (efferocytosis) of apoptotic neutrophils by macrophages anchors the resolution of intestinal inflammation. Efferocytosis prevents secondary necrosis and inhibits further inflammation, and also reprograms macrophages to ...
David Meriwether, Anthony E. Jones, Julianne W. Ashby, R. Sergio Solorzano-Vargas, Nasrin Dorreh, Shoreh Noori, Victor Grijalva, Andréa B. Ball, Margarita Semis, Ajit S. Divakaruni, Julia J. Mack, Harvey R. Herschman, Martin G. Martin, Alan M. Fogelman, Srinivasa T. Reddy   +14 more
doaj   +2 more sources

Metabolic reprogramming in macrophage responses [PDF]

Biomarker Research, 2021
Macrophages are critical mediators of tissue homeostasis, with the function of tissue development and repair, but also in defense against pathogens. Tumor-associated macrophages (TAMs) are considered as the main component in the tumor microenvironment ...
Yang Liu, Ruyi Xu, Huiyao Gu, Enfan Zhang, Jianwei Qu, Wen Cao, Xi Huang, Haimeng Yan, Jingsong He, Zhen Cai   +9 more
doaj   +3 more sources

Metabolic reprogramming in macrophage polarization [PDF]

Frontiers in Immunology, 2014
Studying the metabolism of immune cells in recent years has emphasized the tight link existing between the metabolic state and the phenotype of these cells. Macrophages in particular are a good example of this phenomenon.
Silvia eGalván-Peña, Luke A.J. O'Neill
doaj   +3 more sources

MFG-E8 released by apoptotic endothelial cells triggers anti-inflammatory macrophage reprogramming. [PDF]

PLoS ONE, 2012
Apoptotic endothelial cells are an important component of the "response to injury" process. Several atherosclerosis risk factors such as hyperglycemia and oxidized low-density lipoproteins, and immune injuries, such as antibodies and complement, induce ...
Marie-Joëlle Brissette, Stéphanie Lepage, Anne-Sophie Lamonde, Isabelle Sirois, Jessika Groleau, Louis-Philippe Laurin, Jean-François Cailhier   +6 more
doaj   +2 more sources

Macrophage reprogramming and functional plasticity in sepsis. [PDF]

Front Immunol
Sepsis remains one of the leading causes of mortality worldwide, driven not by the infection itself but by a dysregulated host response that spirals into a cytokine storm and subsequent immune paralysis. This maladaptive immune reaction frequently culminates in life-threatening complications, including multiple organ failure and acute lung injury ...
Huang T, Cheng H, Zhao Q, Li M.
europepmc   +3 more sources

Songorine modulates macrophage polarization and metabolic reprogramming to alleviate inflammation in osteoarthritis [PDF]

Frontiers in Immunology
IntroductionOsteoarthritis (OA) is a prevalent joint disorder characterized by multifaceted pathogenesis, with macrophage dysregulation playing a critical role in perpetuating inflammation and joint degeneration.
Xi-Xi He, Yuan-Jun Huang, Chun-Long Hu, Qiong-Qian Xu, Qing-Jun Wei   +4 more
doaj   +2 more sources

Macrophages and Metabolic Reprograming in the Tumor Microenvironment [PDF]

Frontiers in Oncology, 2022
Due to the emergence of traditional drug resistance in tumor treatment, the anti-cancer therapies are facing multiple challenges. Immunotherapy, as a new and universal treatment, has been gradually concerned. The macrophages, as an important part of the immune system, play an important role in it.
Jin Liu, Jin Liu, Jin Liu, Mingwei Gao, Zhou Yang, Yidan Zhao, Kun Guo, Kun Guo, Binwen Sun, Binwen Sun, Zhenming Gao, Zhenming Gao, Zhenming Gao, Liming Wang, Liming Wang, Liming Wang   +15 more
openaire   +3 more sources

DICERing macrophages for reprogramming TAMs [PDF]

Cell Cycle, 2016
Macrophages are cells of the innate immune system that respond to external stimuli by rapidly adapting their transcriptional programs and behavior.
Squadrito Mario Leonardo, De Palma Michele   +1 more
openaire   +4 more sources