Results 21 to 30 of about 258,864 (288)

Metabolic reprograming of tumor-associated macrophages [PDF]

Annals of Translational Medicine, 2020
A large body of scientific evidence corroborated by clinical and animal model experiments indicates that tumor-associated macrophages (TAMs) play a crucial role in tumor development and progression. TAMs are a key immune cell type present in tumor microenvironment (TME) and associated with poor prognosis, drug resistance, enhanced angiogenesis and ...
Puthenveetil, Abhishek, Dubey, Shweta
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PHD2 Is a Regulator for Glycolytic Reprogramming in Macrophages [PDF]

Molecular and Cellular Biology, 2017
The prolyl-4-hydroxylase domain (PHD) enzymes are regarded as the molecular oxygen sensors. There is an interplay between oxygen availability and cellular metabolism, which in turn has significant effects on the functionality of innate immune cells, such as macrophages. However, if and how PHD enzymes affect macrophage metabolism are enigmatic.
Guentsch, Annemarie, Beneke, Angelika, Swain, Lija, Farhat, Katja, Nagarajan, Shunmugam, Wielockx, Ben, Raithatha, Kaamini, Dudek, Jan, Rehling, Peter, Zieseniss, Anke, Jatho, Aline, Chong, Mei, Santos, Celio X C, Shah, Ajay M., Katschinski, Dörthe M.   +14 more
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Reprogramming macrophages by plasmin [PDF]

Blood, 2017
Resolution of inflammation is a key physiological process regulated at different levels, and failure to achieve resolution may result in chronic inflammation. In this issue of Blood , Sugimoto et al reveal the function of the plasmin system in resolving inflammation by inducing macrophage polarization toward M2 and proresolving phenotypes.
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The circadian regulator PER1 promotes cell reprogramming by inhibiting inflammatory signaling from macrophages.

PLoS Biology, 2023
Circadian regulation of gene expression is prevalent and plays critical roles in cell differentiation. However, its roles in the reprogramming of differentiated cells remain largely unknown. Here, we found that one of the master circadian regulators PER1
Nobuko Katoku-Kikyo, Seunghyun Lim, Ce Yuan, Jinsha Koroth, Yasushi Nakagawa, Elizabeth W Bradley, Nobuaki Kikyo   +6 more
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Reprogramming of macrophages with macrophage cell membrane-derived nanoghosts

Nanoscale Advances, 2020
This study reports the synthesis of nanoghosts for reprogramming M0 macrophages to the M2 type. They are non-toxic, execute reprogramming through surface-bound cytokines/chemokines, and could help the wound healing process by stimulating M2 conversion.
Jangsun Hwang, Mengjia Zheng, Christian Wiraja, Mingyue Cui, Lixia Yang, Chenjie Xu   +5 more
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HIV-1 reprograms the migration of macrophages [PDF]

Blood, 2015
Key PointsHIV-1 Nef reprograms human macrophage migration favoring the mesenchymal mode, which translates in vivo to macrophage tissue accumulation. Nef enhances mesenchymal migration by influencing podosome organization and function via the phagocyte-specific kinase Hck and WASP.
Vérollet, Christel, Souriant, Shanti, Bonnaud, Emilie, Jolicoeur, Paul, Raynaud-Messina, Brigitte, Kinnaer, Cassandre, Fourquaux, Isabelle, Imle, Andrea, Benichou, Serge, Fackler, Oliver, Poincloux, Renaud, Maridonneau-Parini, Isabelle   +11 more
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Suv4-20h abrogation enhances telomere elongation during reprogramming and confers a higher tumorigenic potential to iPS cells [PDF]

, 2011
Reprogramming of adult differentiated cells to induced pluripotent stem cells (iPS) cells has been achieved by over-expression of specific transcription factors.
Maria A. Blasco, Maria A Blasco, Marión, Rosa M., Ortega Sagrario, Marión Rosa M., Schotta Gunnar, Blasco Maria A., Schotta, Gunnar, Rosa M. Marión, Blasco, Maria A., Gunnar Schotta, Sagrario Ortega, Rosa M Marión, Ortega, Sagrario   +13 more
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Gain-of-function oncogenic mutations in TP53 enhance defined factor-mediated cellular reprogramming [PDF]

, 2011
Cancer is a disorder with various genetic and epigenetic alterations. Genetic alterations such as mutations, i.e., substitutions, amplifications, and deletions of nucleotide sequences, are largely irreversible, whereas epigenetic alterations can be ...
Kazuyoshi Yamamoto, Yoshiyuki Fujiwara, Hideshi Ishii, Yoshihiro Kano, Masaki Mori, Dyah Laksmi Dewi, Jeong Ho Moon, Shinpei Nishikawa, Yuichiro Doki   +8 more
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Accumulation of cholesterol suppresses oxidative phosphorylation and altered responses to inflammatory stimuli of macrophages

Biochemistry and Biophysics Reports, 2021
Hypercholesterolemia induces intracellular accumulation of cholesterol in macrophages and other immune cells, causing immunological dysfunctions. On cellular levels, cholesterol enrichment might lead to mitochondrial metabolic reprogramming and change ...
Yi-Chou Chiu, Pei-Wen Chu, Hua-Ching Lin, Shau-Kwaun Chen   +3 more
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Stepwise Reprogramming of B Cells into Macrophages [PDF]

Cell, 2004
Starting with multipotent progenitors, hematopoietic lineages are specified by lineage-restricted transcription factors. The transcription factors that determine the decision between lymphoid and myeloid cell fates, and the underlying mechanisms, remain largely unknown.
Xie, Huafeng, Ye, Min, Feng, Ru, Graf, Thomas   +3 more
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